The development of a theoretical framework for the internationalization process of fast growth medium-sized firms in Europe

The experience of the author and a review of the literature identifies a number of possible limitations in current theories of internationalization. Existing theories can be broadly classified under the headings of either "stage school" or contingency theories. There appears to have been little research on the interface between the two theoretical approaches, nor on the dynamism of the internationalization process within an individual firm. While scholars challenge the current theory, few have attempted to develop or propose alternative theories. Therefore, the central aim and contribution of this doctoral research has been to develop a theoretical framework from the literature, evaluated in an empirical study of European firms. The research and theoretical development, whilst exploratory, suggests that the internationalization process of firms is contingent on exogenous and endogenous influences. These influences are dynamic, complex and vary according to the specific contexts used in the research. The contingency contexts are summarized here as: The industry and country environment in which the organization operates; the mindset of the entrepreneur decision-maker(s); the nature of the product, the market demographics, and the mindset and nature of the seller and buying organization. The results indicate that the theoretical framework is rigorous enough to demonstrate the variety in the internationalization processes of the firms in the study. The findings are, that whilst there are some common processes and patterns among the firms in the study, there are variations, explained by the contingency theory and contexts in which the firms operate. Previous research has neglected specific contexts as important factors in the internationalization process. The thesis addresses this gap in the research by developing the theory in the context of specific sectors (electronics, software and metal-mechanical) countries (UK, Germany, France and Italy), firm size (medium-sized) and fast growth.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Entrepreneurial decision-making in internationalization: propositions from mid-size firms

Research into international entrepreneurship tends to focus on new ventures rather than larger established firms. Few studies have considered why an entrepreneurial manager in an established firm is motivated to undertake international market entry. Propositions relating to factors motivating the international market entry decision of entrepreneurial managers in mid-sized firms are created and evaluated through in-depth interviews with entrepreneurial managers. We find contrary to extant theory that cultural context, industry environment and resource constraints do not motivate or hinder an entrepreneurial manager's decision to internationalize. Rather, the entrepreneurial manager's connection with the customer, tacit knowledge and vision and product-service complexity are the strongest influences on the decision to internationalize, which is moderated by the strength of the business case and resource-based risk tolerance. This implies a much greater strategic approach by entrepreneurial managers than typically portrayed in current literature. Our research provides researchers with grounded propositions for further empirical testing

Environment and Rural Affairs Monitoring & Modelling Programme ERAMMP - Report-32: National Forest in Wales - Evidence Review

This review was commissioned by Welsh Government (WG) from the Environment and Rural Affairs Monitoring and Modelling Programme (ERAMMP) to provide key evidence of potential benefits and disbenefits of woodland creation, woodland expansion and managing undermanaged woodland, to provide an evidence base to inform the development of a National Forest for Wales. During the commissioning process, WG emphasised that the evidence provided must reflect the collective views of the community by reviewing the literature in an objective way highlighting where evidence is contradictory or weak. Within the time available, evidence of causality of impacts, the likely timescales and magnitude of these impacts should be also be presented, for both positive and negative impacts of woodland expansion and management of undermanaged woodlands. This Evidence Pack should also build on the evidence put forward in the ERAMMP Sustainable Farm Scheme (SFS) (https://erammp.wales/en/resources) which included a range of assessments of the value of intervention measures which promoted trees within a landscape setting for a range of environmental, economic and social outcomes. The required rapid production of the review in four months meant an expert approach of key evidence was expected rather than a systematic review. Key topics to cover were selected, in partnership with WG, focussing on issues that could fundamentally change decision-making going forward. The final agreed list was arranged under a series of high-level subject headings, and the individual reviews published as ERAMMP Reports 33 to 38 and include; Biodiversity; Managing Undermanaged Woodland; Future-proofing our Woodland; Climate Change Mitigation; Ecosystem Services, and Economics and Natural Capital Accounting. An Integrated Assessment was also commissioned to provide a synthesis of cross-cutting themes and dependencies between topics. These ERAMMP reports are all provided as Annexes to this report

Impact of primary kidney disease on the effects of empagliflozin in patients with chronic kidney disease: secondary analyses of the EMPA-KIDNEY trial

Background: The EMPA KIDNEY trial showed that empagliflozin reduced the risk of the primary composite outcome of kidney disease progression or cardiovascular death in patients with chronic kidney disease mainly through slowing progression. We aimed to assess how effects of empagliflozin might differ by primary kidney disease across its broad population. Methods: EMPA-KIDNEY, a randomised, controlled, phase 3 trial, was conducted at 241 centres in eight countries (Canada, China, Germany, Italy, Japan, Malaysia, the UK, and the USA). Patients were eligible if their estimated glomerular filtration rate (eGFR) was 20 to less than 45 mL/min per 1·73 m2, or 45 to less than 90 mL/min per 1·73 m2 with a urinary albumin-to-creatinine ratio (uACR) of 200 mg/g or higher at screening. They were randomly assigned (1:1) to 10 mg oral empagliflozin once daily or matching placebo. Effects on kidney disease progression (defined as a sustained ≥40% eGFR decline from randomisation, end-stage kidney disease, a sustained eGFR below 10 mL/min per 1·73 m2, or death from kidney failure) were assessed using prespecified Cox models, and eGFR slope analyses used shared parameter models. Subgroup comparisons were performed by including relevant interaction terms in models. EMPA-KIDNEY is registered with ClinicalTrials.gov, NCT03594110. Findings: Between May 15, 2019, and April 16, 2021, 6609 participants were randomly assigned and followed up for a median of 2·0 years (IQR 1·5–2·4). Prespecified subgroupings by primary kidney disease included 2057 (31·1%) participants with diabetic kidney disease, 1669 (25·3%) with glomerular disease, 1445 (21·9%) with hypertensive or renovascular disease, and 1438 (21·8%) with other or unknown causes. Kidney disease progression occurred in 384 (11·6%) of 3304 patients in the empagliflozin group and 504 (15·2%) of 3305 patients in the placebo group (hazard ratio 0·71 [95% CI 0·62–0·81]), with no evidence that the relative effect size varied significantly by primary kidney disease (pheterogeneity=0·62). The between-group difference in chronic eGFR slopes (ie, from 2 months to final follow-up) was 1·37 mL/min per 1·73 m2 per year (95% CI 1·16–1·59), representing a 50% (42–58) reduction in the rate of chronic eGFR decline. This relative effect of empagliflozin on chronic eGFR slope was similar in analyses by different primary kidney diseases, including in explorations by type of glomerular disease and diabetes (p values for heterogeneity all >0·1). Interpretation: In a broad range of patients with chronic kidney disease at risk of progression, including a wide range of non-diabetic causes of chronic kidney disease, empagliflozin reduced risk of kidney disease progression. Relative effect sizes were broadly similar irrespective of the cause of primary kidney disease, suggesting that SGLT2 inhibitors should be part of a standard of care to minimise risk of kidney failure in chronic kidney disease. Funding: Boehringer Ingelheim, Eli Lilly, and UK Medical Research Council

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

Mitochondrial physiology

As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

An exploratory study conceptualising marketing thought in entrepreneurial medium-sized firms in high-tech and conventional industries in France, Germany and Italy

The research on the interface between entrepreneurship and marketing has emerged as one of the major research constructs in the past decade. We employ a grounded theory and multiple case methodology approach exploring perceptions and practices of marketing among entrepreneurs in medium-sized firms in France, Germany and Italy in conventional and high-tech industries. We examine the ideas of entrepreneurs on various market orientation issues identified in the literature, namely, opportunistic behaviour, sales and marketing approach, visioning of the future, and customer orientation. We also explore the entrepreneur's conceptualisation of marketing and approaches to strategy and planning. The findings suggest that the approach of entrepreneurs to their strategic and marketing thinking is contingent on the context. The paper contributes to the ongoing debate of the role of entrepreneurship in developing our knowledge of marketing by providing empirical evidence of entrepreneurial thought on strategy and marketing, as well as emphasising the context-specific nature of entrepreneurial decision making.</p