337 research outputs found

    Sobre las vĂ­as a la reducciĂłn trascendental de Husserl segĂşn Iso Kern

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    I challenge Kern’s theory concerning the three ways to Husserl’s transcendental reduction from the point of view of its theoretical content and its examples. I argue that this theory is built upon the idea of attributive conditioning and the concomitant hypothesis of the textual discontinuity of the ways. My refutation focuses on internal contradictions of the theory and the lack of contextual examples.Critico la teoría de las tres vías de Iso Kern desde el punto de vista de su contenido teórico y de los ejemplos provistos para justificarse. Argumento que esta teoría se caracteriza por crear la idea de condicionalidad atributiva y la hipótesis concomitante necesaria de la discontinuidad textual de las vías. Mi refutación señala, primero, contradicciones internas en la misma teoría y, segundo, la falta de un ajuste entre la teoría y sus documentos respectivos

    Comparison of Spectra in Unsequenced Species

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    International audienceWe introduce a new algorithm for the mass spectromet- ric identication of proteins. Experimental spectra obtained by tandem MS/MS are directly compared to theoretical spectra generated from pro- teins of evolutionarily closely related organisms. This work is motivated by the need of a method that allows the identication of proteins of unsequenced species against a database containing proteins of related organisms. The idea is that matching spectra of unknown peptides to very similar MS/MS spectra generated from this database of annotated proteins can lead to annotate unknown proteins. This process is similar to ortholog annotation in protein sequence databases. The difficulty with such an approach is that two similar peptides, even with just one mod- ication (i.e. insertion, deletion or substitution of one or several amino acid(s)) between them, usually generate very dissimilar spectra. In this paper, we present a new dynamic programming based algorithm: Packet- SpectralAlignment. Our algorithm is tolerant to modications and fully exploits two important properties that are usually not considered: the notion of inner symmetry, a relation linking pairs of spectrum peaks, and the notion of packet inside each spectrum to keep related peaks together. Our algorithm, PacketSpectralAlignment is then compared to SpectralAlignment [1] on a dataset of simulated spectra. Our tests show that PacketSpectralAlignment behaves better, in terms of results and execution tim

    Study of Interplanetary Magnetic Field with Ground State Alignment

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    We demonstrate a new way of studying interplanetary magnetic field -- Ground State Alignment (GSA). Instead of sending thousands of space probes, GSA allows magnetic mapping with any ground telescope facilities equipped with spectropolarimeter. The polarization of spectral lines that are pumped by the anisotropic radiation from the Sun is influenced by the magnetic realignment, which happens for magnetic field (<1G). As a result, the linear polarization becomes an excellent tracer of the embedded magnetic field. The method is illustrated by our synthetic observations of the Jupiter's Io and comet Halley. Polarization at each point was constructed according to the local magnetic field detected by spacecrafts. Both spatial and temporal variations of turbulent magnetic field can be traced with this technique as well. The influence of magnetic field on the polarization of scattered light is discussed in detail. For remote regions like the IBEX ribbons discovered at the boundary of interstellar medium, GSA provides a unique diagnostics of magnetic field.Comment: 11 pages, 19 figures, published in Astrophysics and Space Scienc

    AGENDA: Two Decades of Water Law and Policy Reform: A Retrospective and Agenda for the Future

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    1 v. (various pagings) ; 29 cm Sponsors: Hydrosphere Resource Consultants; Modrall, Sperling, Roehl, Harris & Sisk, P.A.; Patrick & Stowell, P.C.; Perkins Coie LLP; The William and Flora Hewlett Foundation. Conference speakers, moderators and/or panelists included University of Colorado School of Law professors Gary C. Bryner, Douglas S. Kenney, Sarah Krakoff, Kathryn Mutz, David H. Getches, Lawrence J. MacDonnell and James N. Corbridge, Jr. Includes bibliographical references The conference will examine the agenda for reforming and improving water law that has developed during the past two decades in the West, assesses what has (and has not) been accomplished by pursuing these reforms, and explores lessons and implications for future water law and policy. The papers and discussion will provide analysis and lessons that can guide the new administration, Congress, federal agencies, state governments, and communities as they seek to find policy solutions to the challenges posed by the tremendous economic and demographic changes occurring in the West, in order to ensure the sustainability of the region\u27s unique environment. Specific sessions will focus on reforms such as improving the scientific and technical basis for water management, water conservation and efficiency, protecting environmental values in meeting water demands, and creating new models of governance for water issues

    Scaling anomaly in cosmic string background

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    We show that the classical scale symmetry of a particle moving in cosmic string background is broken upon inequivalent quantization of the classical system, leading to anomaly. The consequence of this anomaly is the formation of single bound state in the coupling interval \gamma\in(-1,1). The inequivalent quantization is characterized by a 1-parameter family of self-adjoint extension parameter \omega. It has been conjectured that the formation of loosely bound state in cosmic string background may lead to the so called anomalous scattering cross section for the particles, which is usually seen in molecular physics.Comment: 4 pages,1 figur

    Optical spectroscopic study of the interplay of spin and charge in NaV2O5

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    We investigate the temperature dependent optical properties of NaV2O5, in the energy range 4meV-4eV. The symmetry of the system is discussed on the basis of infrared phonon spectra. By analyzing the optically allowed phonons at temperatures below and above the phase transition, we conclude that a second-order change to a larger unit cell takes place below 34 K, with a fluctuation regime extending over a broad temperature range. In the high temperature undistorted phase, we find good agreement with the recently proposed centrosymmetric space group Pmmn. On the other hand, the detailed analysis of the electronic excitations detected in the optical conductivity, provides direct evidence for a charge disproportionated electronic ground-state, at least on a locale scale: A consistent interpretation of both structural and optical conductivity data requires an asymmetrical charge distribution on each rung, without any long range order. We show that, because of the locally broken symmetry, spin-flip excitations carry a finite electric dipole moment, which is responsible for the detection of direct two-magnon optical absorption processes for E parallel to the a axis. The charged-magnon model, developed to interpret the optical conductivity of NaV2O5, is described in detail, and its relevance to other strongly correlated electron systems, where the interplay of spin and charge plays a crucial role in determining the low energy electrodynamics, is discussed.Comment: Revtex, 19 pages, 16 postscript pictures embedded in the text, submitted to PRB. Find more stuff at http://www.stanford.edu/~damascel/andreaphd.html or http://www.ub.rug.nl/eldoc/dis/science/a.damascelli

    The Value of Information for Populations in Varying Environments

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    The notion of information pervades informal descriptions of biological systems, but formal treatments face the problem of defining a quantitative measure of information rooted in a concept of fitness, which is itself an elusive notion. Here, we present a model of population dynamics where this problem is amenable to a mathematical analysis. In the limit where any information about future environmental variations is common to the members of the population, our model is equivalent to known models of financial investment. In this case, the population can be interpreted as a portfolio of financial assets and previous analyses have shown that a key quantity of Shannon's communication theory, the mutual information, sets a fundamental limit on the value of information. We show that this bound can be violated when accounting for features that are irrelevant in finance but inherent to biological systems, such as the stochasticity present at the individual level. This leads us to generalize the measures of uncertainty and information usually encountered in information theory

    The First VERITAS Telescope

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    The first atmospheric Cherenkov telescope of VERITAS (the Very Energetic Radiation Imaging Telescope Array System) has been in operation since February 2005. We present here a technical description of the instrument and a summary of its performance. The calibration methods are described, along with the results of Monte Carlo simulations of the telescope and comparisons between real and simulated data. The analysis of TeV Îł\gamma-ray observations of the Crab Nebula, including the reconstructed energy spectrum, is shown to give results consistent with earlier measurements. The telescope is operating as expected and has met or exceeded all design specifications.Comment: Accepted by Astroparticle Physic

    A genetic locus on chromosome 2q24 predicting peripheral neuropathy risk in type 2 diabetes: Results from the ACCORD and BARI 2D studies

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    Genetic factors have been postulated to be involved in the etiology of diabetic peripheral neuropathy (DPN), but their identity remains mostly unknown. The aim of this study was to conduct a systematic search for genetic variants influencing DPN risk using two wellcharacterized cohorts. A genome-wide association study (GWAS) testing 6.8 million single nucleotide polymorphisms was conducted among participants of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) clinical trial. Included were 4,384 white case patients with type 2 diabetes (T2D) and prevalent or incident DPN (defined as a Michigan Neuropathy Screening Instrument clinical examination score &gt;2.0) and 784 white control subjects with T2D and no evidence of DPN at baseline or during follow-up. Replication of significant loci was sought among white subjects with T2D (791 DPN-positive case subjects and 158 DPNnegative control subjects) from the Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes (BARI 2D) trial. Association between significant variants and gene expression in peripheral nerves was evaluated in the Genotype-Tissue Expression (GTEx) database. A cluster of 28 SNPs on chromosome 2q24 reached GWAS significance (P &lt; 5Ă—10-8) in ACCORD. The minor allele of the lead SNP (rs13417783,minor allele frequency = 0.14) decreased DPN odds by 36%(odds ratio [OR] 0.64, 95% CI 0.55-0.74, P = 1.9Ă—10-9). This effect was not influenced by ACCORD treatment assignments (P for interaction = 0.6) or mediated by an association with known DPN risk factors. This locus was successfully validated in BARI 2D (OR 0.57, 95%CI 0.42-0.80,P=9Ă—10-4; summary P=7.9Ă—10-12). In GTEx, the minor, protective allele at this locus was associated with higher tibial nerve expression of an adjacent gene (SCN2A) coding for human voltage-gated sodium channel NaV1.2 (P = 9Ă—10-4). To conclude, we have identified and successfully validated a previously unknown locus with a powerful protective effect on the development of DPN in T2D. These results may provide novel insights into DPN pathogenesis and point to a potential target for novel interventions
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