22 research outputs found
Sistemski vaskulitis nakon cijepljenja u inkubacijskom periodu infekcije COVID -19: prikaz BOLESNIKA
KroniÄne nezarazne bolesti kod hrvatskih branitelja u odnosu na opÄu populaciju: 25 godina nakon rata
Many published reports have documented an increased prevalence of chronic
medical conditions among veterans, but there were only a few studies that compared these increases
with the general population. The aim of this study was to determine differences in chronic medical
conditions between Croatian war veterans and the general population. This study included two
groups of subjects, i.e. 1453 participants who are Croatian war veterans and 1429 participants from
the general population. Medical history, physical examination, laboratory tests and specific diagnostic
procedures were taken during systematic physical examination in both groups. The prevalence
of hypertension, diabetes, hyperlipidemia, hypothyroidism and hyperthyroidism, chronic obstructive
pulmonary disease, coronary heart disease, malignancy, psychiatric diseases, cholelithiasis, nephrolithiasis,
smoking and alcohol consumption was analyzed. Croatian war veterans were found to be more
likely to develop hypertension than individuals in the general population (29.5% vs. 24.3%), as well
as diabetes (7.3% vs. 3.8%), hyperlipidemia (56.4% vs. 27.3%), hyperthyroidism (3.1% vs. 0.8%), coronary
heart disease (4.3% vs. 1 %), malignancy (4.1% vs. 2.2%), psychiatric diseases (15.4% vs. 1.1%),
and alcohol consumption (53% vs. 29%). Significant difference was found in favor of the general
population for hypothyroidism (14.3% vs. 8%). There were no differences in the prevalence of chronic
obstructive pulmonary disease, cholelithiasis, nephrolithiasis, and smoking. Our findings confirmed
the hypothesis of a higher prevalence of cardiovascular diseases, malignancy and psychiatric diseases
among Croatian war veterans and emphasized the need of better control of their medical conditions.PoveÄana uÄestalost kroniÄnih bolesti meÄu veteranima dokumentirana je kroz brojna istraživanja, no samo ih je nekoliko
studija usporeÄivalo s opÄom populacijom. Cilj ovog istraživanja bio je utvrditi razlike u pojavnosti kroniÄnih bolesti izmeÄu
hrvatskih branitelja i opÄe populacije. Ovo istraživanje obuhvatilo je dvije skupine ispitanika, 1453 hrvatskih branitelja i
1429 sudionika iz opÄe populacije. Anamneza, fizikalni pregled, laboratorijske pretrage i specifiÄni dijagnostiÄki postupci
provedeni su tijekom sistematskog fizikalnog pregleda u obje skupine. Analizirana je uÄestalost hipertenzije, Å”eÄerne bolesti,
hiperlipidemije, hipotireoze i hipertireoze, kroniÄne opstruktivne pluÄne bolesti, koronarne bolesti, malignih bolesti, psihijatrijskih
bolesti, kolelitijaze, nefrolitijaze, puÅ”enja i konzumacije alkohola. UtvrÄeno je da hrvatski branitelji imaju veÄu
vjerojatnost za razvoj hipertenzije (29,5% prema 24,3%), dijabetesa (17,3% prema 3,8%), hiperlipidemije (56,4% prema
27,3%), hipertireoze (3,1% prema 0,8%), koronarne bolesti srca (4,3% naspram 1%), zloÄudne bolesti (4,1% naspram 2,2%),
psihijatrijske bolesti (15,4% naspram 1,1%) i ÄeÅ”Äu konzumaciju alkohola (53% naspram 29%) nego pojedinci u opÄoj populaciji.
UoÄena je znaÄajna razlika u korist opÄe populacije za hipotireozu (14,3% naspram 8%). Nije bilo razlika u uÄestalosti
kroniÄne opstruktivne pluÄne bolesti, kolelitijaze, nefrolitijaze i puÅ”enja. NaÅ”i nalazi potvrdili su hipotezu o viÅ”oj uÄestalosti
kardiovaskularnih bolesti, malignih i psihijatrijskih bolesti meÄu hrvatskim braniteljima te naglasili potrebu bolje kontrole
njihovog zdravstvenog stanja
Use of bendamustin instead of carmustin in autologous stem cell transplantation conditioning ā toxicity and infectious complications comparison
Unatrag nekoliko godina u hematologiji i onkologiji globalno sve ÄeÅ”Äi problem postaje prikladna opskrba āstarijim i manje zanimljivimā kemoterapeuticima. Zbog povremene nestaÅ”ice karmustina, jednog od osnovnih kemoterapeutika pri kondicioniranju prije autologne transplantacije krvotvornih matiÄnih stanica (ATK S) u oboljelih od
limfoma, u naÅ”em se centru od 2016. godine on zamjenjuje bendamustinom. U ovom radu retrospektivno analiziramo tijek ATK S-a u 41 bolesnika koji su primili bendamustin u sklopu protokola BeEA M te ga usporeÄujemo s tijekom ATK S-a u 40 bolesnika koji su primili karmustin u sklopu protokola BEA M. Medijan oporavka vrijednosti neutrofila (> 0,5 Ć 109/l) u skupini koja je primila bendamustin iznosio je 11 dana, dok je u skupini kondicioniranoj karmustinom iznosio 10 dana. Medijan oporavka vrijednosti trombocita (> 20 Ć 109/l) bio je duži kod skupine koja je primala bendamustin (16 prema 13 dana) te su ti bolesnici bili duže ovisni o transfuzijama eritrocita (7 prema 5 dana). Infektivne komplikacije nisu bile ÄeÅ”Äe nakon primjene bendamustina, ali smo nakon primjene karmustina imali veÄu pojavu mukozitisa II. ā III. stupnja (35% prema 12%). Nakon primjene bendamustina zabilježen je jedan sluÄaj nefrotoksiÄnosti i kardiotoksiÄnosti terapije, dok kod primjene karmustina te komplikacije nisu zabilježene. Pri upotrebi bendamustina kod kondicioniranja u naÅ”ih bolesnika u ovom trenutku nije utvrÄena znatnija hematoloÅ”ka toksiÄnost u odnosu prema karmustinu, ali su prisutni dulji period oporavka vrijednosti trombocita te niža incidencija mukozitisa.Inadequate supply of āold and less interestingā chemotherapeutic agents is becoming a global issue in hemato-oncology today. In 2016 we were faced with occasional carmustin shortage, one of the most commonly used in autologous transplant conditioning regimens for lymphoma in our centre, so we decided to use bendamustin instead. We
performed a retrospective analysis of 41 patients treated at our centre who had received bendamustin within BeEA M protocol and compared them with 40 patients who had received carmustin within BEA M protocol. Both protocols were used as conditioning protocols before autologous stem cell transplantation. Neutrophil recovery median following transplantation (AN C>0,5x109/l) was 11 days in the bendamustin group in comparison to 10 days in the carmustin group.Platelets recovery median following transplantation (PLT>20x109/l) was longer in the bendamustin group (16 vs.13 days) as was blood transfusion dependency (7 vs. 5 days). Infectious complications were not more frequent after bendamustin, but grade IIāIII mucositis was more frequent in patients who received carmustin (35% vs.12%). Following bendamustin we had one reported case of nephrotoxicity and cardiac toxicity, not reported with carmustin. Bendamustin has shown similar hematologic toxicity compared to carmustin but a longer platelet recovery period and a lower mucositis incidence
Chronic Kidney Disease has a Higher Prevalence in Polycythemia Vera than in Secondary Polycythemia, a Matched CaseāControl Analysis
PB2201: ASSOCIATION OF HIGH PLATELETCRIT WITH THROMBOTIC RISK IN POLYCYTHEMIA VERA DEPENDS ON HEMATOCRIT AND LEUKOCYTE COUNT
PB2188: PROTON PUMP INHIBITORS ARE SAFE AND EFFECTIVE IN PATIENTS WITH ESSENTIAL THROMBOCYTHEMIA AND POLYCYTHEMIA VERA TREATED WITH LOW-DOSE ASPIRIN
The triple A model (age, absolute neutrophil count, absolute lymphocyte countā AAA ) predicts survival and thrombosis in polycythemia vera
Reduced renal function strongly affects survival and thrombosis in patients with myelofibrosis
We retrospectively investigated a cohort of 176 myelofibrosis patients (128 primary-PMF; 48 secondary-SMF) from five hematology centers. The presence of chronic kidney disease (CKD) was determined in addition to other clinical characteristics. CKD was present in 26.1% of MF patients and was significantly associated with older age (P 0.05 for all analyses). The presence of CKD was significantly associated with shorter time to arterial (HR = 3.49; P = 0.041) and venous thrombosis (HR = 7.08; P = 0.030) as well as with shorter overall survival (HR 2.08; P = 0.009). In multivariate analyses, CKD (HR = 1.8; P = 0.014) was associated with shorter survival independently of the DIPSS (HR = 2.7; P < 0.001); its effect being more pronounced in lower (HR = 3.56; P = 0.036) than higher DIPSS categories (HR = 2.07; P = 0.023). MF patients with CKD should be candidates for active management aimed at the improvement of renal function. Prospective studies defining the optimal therapeutic approach are highly needed