Socioeconomic Factors and the Consumption of Wine in Tenerife

In this paper we measure the impact of an individual's socioeconomic conditions on the decision to consume wine in a traditionally wine-producing area. Based on the data obtained in an exhaustive survey on wine consumption and through discrete choice models, we assess the changes which come about in the decisions to consume the different types of wine under consideration, and we obtain the most relevant distinctive and differentiated characteristics for each one of them.wine consumption, socioeconomic characteristics, discrete choice models, Food Consumption/Nutrition/Food Safety,

The forensic analysis of soil by FTIR with multivariate analysis

Over the past few years more and more studies have been carried out in an attempt to utilize chemical profiles of soil using a wide variety of analytical methods. The value of soil as evidence rests with its prevalence at crime scenes and its transferability between the scene and the criminal. This can be of value for comparison if the scene of crime is known, but could also be so in the identification of a scene. The main basis for the comparison of sites to determine provenance is that soils vary from one place to another. The aim of this work is to find simple methods to identify soil provenance based on FTIR and multivariate analysi

A developmental model for the pathogenenesis of cardiac arterio-ventricular fistulae

Coronary Artery Fistulae (CAF) are congenital coronary artery (CA) anomalies consisting of an abnormal communication of a coronary artery with either a cardiac chamber or a large cardiac vessel. Although their incidence in the Western population is low, CAF can lead to complications such as myocardial hypertrophy, endocarditis, heart dilatation and cardiac failure. CAFs can appear as an isolated anomaly or linked to some other forms of congenital heart disease like Left Ventricular Non-Compaction (LVNC) and intrinsic CA anatomy anomalies, but their etiology remains unknown. In this work we have used two different experimental models (transgenic mice and avian embryos) to investigate on the developmental mechanics of CAF formation. In order to tackle this goal, we have manipulated epicardial development and ventricular wall compaction, two inextricably related developmental events during coronary embryogenesis. Conditional integrin α4 gene deletion in the septum transversum/proepicardial (ST/PE) region (G2-Gata4+) disrupts early epicardium development and reduces cardiomyocyte proliferation, leading to the thinning of the ventricular compact myocardial layer. Reduction in compact myocardium thickness associates to the presence of multiple ventricular myocardial discontinuities and focal endocardial extrusion. This same phenotype can be experimentally reproduced in chick embryos using a cryocauterization method (Palmquist-Gomes et al., 2016). Our results suggest that the partial absence of epicardium in α4integrin;G2-Gata4Cre mouse embryos and the cryoinjury in avian embryos generate myocardial discontinuities in the embryonic ventricular wall, which promote endocardial extrusion towards the pericardial cavity and the early contact of the endocardium with coronary progenitors at the epicardial surface of the heart. In the case of avian embryos, this phenomenon leads to precocious smooth muscle differentiation from epicardial mesenchymal cells, and the formation of pouch-like structures that closely resemble CAF. We conclude that anomalous compact myocardial embryonic growth can originate CAF.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

A developmental model for the pathogenenesis of cardiac arterio-ventricular fistulae

Coronary Artery Fistulae (CAF) are congenital coronary artery (CA) anomalies consisting of an abnormal communication of a coronary artery with either a cardiac chamber or a large cardiac vessel. Although their incidence in the Western population is low, CAF can lead to complications such as myocardial hypertrophy, endocarditis, heart dilatation and cardiac failure. CAFs can appear as an isolated anomaly or linked to some other forms of congenital heart disease like Left Ventricular Non-Compaction (LVNC) and intrinsic CA anatomy anomalies, but their etiology remains unknown. In this work we have used two different experimental models (transgenic mice and avian embryos) to investigate on the developmental mechanics of CAF formation. In order to tackle this goal, we have manipulated epicardial development and ventricular wall compaction, two inextricably related developmental events during coronary embryogenesis. Conditional integrin α4 gene deletion in the septum transversum/proepicardial (ST/PE) region (G2-Gata4+) disrupts early epicardium development and reduces cardiomyocyte proliferation, leading to the thinning of the ventricular compact myocardial layer. Reduction in compact myocardium thickness associates to the presence of multiple ventricular myocardial discontinuities and focal endocardial extrusion. This same phenotype can be experimentally reproduced in chick embryos using a cryocauterization method (Palmquist-Gomes et al., 2016). Our results suggest that the partial absence of epicardium in α4integrin;G2-Gata4Cre mouse embryos and the cryoinjury in avian embryos generate myocardial discontinuities in the embryonic ventricular wall, which promote endocardial extrusion towards the pericardial cavity and the early contact of the endocardium with coronary progenitors at the epicardial surface of the heart. In the case of avian embryos, this phenomenon leads to precocious smooth muscle differentiation from epicardial mesenchymal cells, and the formation of pouch-like structures that closely resemble CAF. We conclude that anomalous compact myocardial embryonic growth can originate CAF.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Coup-TFII expression defines two different septum transversum cell compartments crucial to cardiac septation and compact ventricular wall growth

COUP-TFII encodes for an orphan nuclear receptor expressed by multiple embryonic tissues. COUP-TFII functions include the regulation of mesodermal progenitor differentiation and cell fate specification, and is required for completion of cardiovascular development as shown by the early death (E9.5) of COUP-TFII-null mice. In this study, we show that COUP-TFII, which is strongly expressed in the atrial myocardium, is also expressed in two different compartments of the septum transversum (ST, E9.5), a mesodermal folding adjacent to cardiac inflow myocardium. The first ST compartment is COUP-TFII+/Isl1+; cells in this compartment concentrate in the posterior part of the ST, overlap with SHF, and are continuous with the dorsal mesenchymal protrusion (DMP, also known as spina vestibuli). The second compartment is characteristically COUP-TFII+/Isl1-, and comprises the majority of proepicardial cells. To dissect the role of COUP-TFII+ ST cells in cardiac development, we conditionally deleted COUP-TFII in the ST using two different Cre constructs (Wt1Cre; G2-Gata4Cre). We show that COUP-TFII deletion in the ST is most severe in G2-Gata4Cre;COUP-TFII-/- mice, containing various cardiovascular progenitor lineages. Mutant mice display atrial septation and atrioventricular septal defects as well as a severe disruption of compact ventricular myocardial growth and coronary vascularization. We conclude that COUP-TFII plays critical, pleiotropic, tissue-dependent roles during cardiac septation, growth and vascularization.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Centro Nacional de Investigaciones Cardiovasculares (CNIC-ISCIII

O palafito que muda a sua vida... uma grande experiência de apoio nutricional e alimentar

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Developing a predator-prey model for the hake and blue whiting spanish fisheries.pdf

The aim of this work is to develop a predator-prey model for two species of commercial importance captured by the Spanish fishing fleet in the National Fishing Ground (ICES areas VIIIc and IXa). In this model, the Southern hake (Merluccius merluccius) represents the predator, and the blue whiting (Micromesistius poutassou) is the prey. Blue whiting is the hake’s main prey in the study area, and it represents about 40% of the Southern hake diet. Both the predator and prey population dynamics follow the Lotka-Volterra formulation, and population dynamics are assumed as logistic, with two interaction coefficients: α is the effect of a unit change in the prey on the percent growth rate of the predator and β is the attack rate or searching efficiency of the predator. The populations interact randomly in proportion to population density. Logistic predator-prey equations were applied to the Southern hake and blue whiting stocks, including biomass, intrinsic rates of growth, carrying capacity and capture for both species. The goal is to maximize the present value of profit, forming the current value Hamiltonian for the maximization problem. Capture costs and prices of hake and blue whiting and discount rate were introduced at this point. Landings and SSB (Spawning Stock Biomass) data from both stocks over the period 1988-2010 were used for an econometric estimation by means of the Ordinary Least Squares method, to determine the form taken by the predator-prey net growth functions

Como conduzir a investigação científica em nutrição clínica?

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Proposta de intervenção para diminuir a incidência e complicações do diabetes mellitus em usuários da área de abrangência do PSF "Nossa Senhora das Graças" no município de Pará de Minas/MG

A prevalência do Diabetes Mellitus vem crescendo consideravelmente nos últimos anos, convertendo-se em um grande problema de saúde pública no Brasil e no mundo, tanto por sua mortalidade quanto por sua morbidade. As complicações do paciente diabético principalmente a nefropatia, retinopatia, neuropatia diabética, assim como complicações cardiovasculares se apresentam fundamentalmente nos pacientes descompensados. Nossa área de abrangência, o PSF Nossa Senhora das Graças, priorizou esse problema para a elaboração da proposta de intervenção, causado pelo baixo nível de conhecimentos da equipe, dos pacientes e seus familiares, pelo estilo de vida inadequado e problemas no processo de trabalho da equipe de saúde. O controle metabólico desta doença é um verdadeiro desafio para nós, profissionais da atenção primária em saúde. Este trabalho tem como objetivo elaborar um plano de intervenção para diminuir a incidência e complicações do Diabetes Mellitus em usuários da área de abrangência do PSF Nossa Senhora das Graças no município de Pará de Minas/MG, visando aumentar a organização do trabalho da equipe de saúde, assim como a qualidade na atenção, conseguindo uma maior adesão ao tratamento e estilos de vida mais saudáveis que levem a melhorar a qualidade de vida destes pacientes e prevenir casos novo