The Effects of Cuento Therapy on Reading Achievement and Psychological Outcomes of Mexican-American Students

This investigation evaluated the effects of cuento therapy (an intervention using Spanish-language tales) on children’s self-esteem, affect, and reading test performance. The sample was composed of 58 third-grade Mexican-American students who were randomly assigned to the treatment and control groups. The results showed a mean self-esteem gain score difference between groups in favor of the treatment group for Global, Academic, and General self-esteem scores. Following intervention, the treatment group reported less physiological anxiety than did the control group. The results also showed mean increases in the pre- and post-standardized high-stakes reading test scores for both groups. Other significant findings regarding selfesteem and anxiety are reported

The Element(s) at the Nontranscribed Xist Locus of the Active X Chromosome Controls Chromosomal Replication Timing in the Mouse

In female mammalian cells, the inactive X chromosome is replicated late in S phase while the active X chromosome is replicated earlier. The replication times of the X chromosomes reflect a general trend in which late replication is associated with gene repression and earlier replication with transcriptional competence. The X-linked Xist gene is expressed exclusively from the inactive X chromosome where it is involved in the initiation and maintenance of X-inactivation. In contrast, no biological activity has been assigned to the Xist locus of the active X chromosome where the Xist gene is transcriptionally silenced. Here, we provide evidence that the element(s) at the nontranscribed Xist locus of the active X chromosome controls chromosomal replication timing in cis

Matemática Financiera-AF141-201700

Curso general en la carrera de Administración de carácter teórico-práctico dirigido a los estudiantes del 2do ciclo que busca desarrollar las competencias generales de Razonamiento Cuantitativo al nivel 2 y Pensamiento Innovador al nivel 1 así como la competencia específica de Toma de Decisiones al nivel 1.El curso introduce al alumno al mundo de las finanzas proporcionándole las herramientas necesarias para el cálculo de resultados financieros que le permita tomar decisiones de inversión y financiamiento. Se orienta a que el alumno identifique los criterios que le permita seleccionar las alternativas que generan mayor valor en una organización

Interplay between Oxidative Stress, Inflammation, and Amyloidosis in the Anterior Segment of the Eye; Its Pathological Implications

There are different pathologies associated with amyloidogenic processes caused by the increase of reactive oxygen species (ROS) and the overactivation of inflammatory responses. These alterations are present in different regions of the anterior segment of the eye, and they have been associated with the development and progression of ocular pathologies, such as glaucoma, dry eye syndrome, keratitis, and cataracts among other pathologies. Aim. To discuss briefly the anatomical characteristics of the anterior segment of the eye and describe the interaction between oxidative stress (OS) and inflammatory responses, emphasizing the misfolding of several proteins leading to amyloidogenic processes occurring in the anterior segment and their implications in the development of ocular diseases. We performed a search on PubMed, CINAHL, and Embase using the MeSH terms “eye,” “anterior segment”, “inflammation”, “oxidative stress”, and “amyloidosis”. The search encompassed manuscripts published up to April 2019. A hundred forty-four published studies met the inclusion criteria. We present the current knowledge regarding the interaction between OS and the activation of inflammatory processes and how both can cause conformational changes in several peptides and proteins in each compartment of the anterior segment. However, we found that there is no consensus about which factor is the first to cause amyloidosis. Our conclusions suggest that there is an interplay among these factors forming a vicious cycle that leads to the loss of protein structure in ocular pathologies, and multifactorial therapies should be developed to avoid protein misfolding and to stop the progression of ocular pathologies

Matemática Financiera- AF141- 202201

El curso general en la carrera de Administración, de carácter teórico-práctico dirigido a los estudiantes del 3er ciclo, el curso introduce al alumno al mundo de las finanzas, proporcionándole las herramientas necesarias para el cálculo de resultados financieros que puede aplicar en el proceso de tomar decisiones de inversión y financiamiento. Se orienta a que el alumno identifique los criterios que le permita seleccionar las alternativas de inversión y financiamiento que generan mayor valor en una organización. Propósito: El curso busca desarrollar las competencias generales de Razonamiento Cuantitativo al nivel 2 y Pensamiento Innovador al nivel 1, así como la competencia específica de Toma de Decisiones al nivel 1

Matemática Financiera- AF141- 202202

El curso general en la carrera de Administración, de carácter teórico-práctico dirigido a los estudiantes del 3er ciclo, el curso introduce al alumno al mundo de las finanzas, proporcionándole las herramientas necesarias para el cálculo de resultados financieros que puede aplicar en el proceso de tomar decisiones de inversión y financiamiento. Se orienta a que el alumno identifique los criterios que le permita seleccionar las alternativas de inversión y financiamiento que generan mayor valor en una organización. Propósito: El curso busca desarrollar la competencia específica de Toma de Decisiones al nivel 1

FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension

Dysfunctional bone morphogenetic protein receptor-2 (BMPR2) signaling is implicated in the pathogenesis of pulmonary arterial hypertension (PAH). We used a transcriptional high-throughput luciferase reporter assay to screen 3,756 FDA-approved drugs and bioactive compounds for induction of BMPR2 signaling. The best response was achieved with FK506 (tacrolimus), via a dual mechanism of action as a calcineurin inhibitor that also binds FK-binding protein-12 (FKBP12), a repressor of BMP signaling. FK506 released FKBP12 from type I receptors activin receptor-like kinase 1 (ALK1), ALK2, and ALK3 and activated downstream SMAD1/5 and MAPK signaling and ID1 gene regulation in a manner superior to the calcineurin inhibitor cyclosporine and the FKBP12 ligand rapamycin. In pulmonary artery endothelial cells (ECs) from patients with idiopathic PAH, low-dose FK506 reversed dysfunctional BMPR2 signaling. In mice with conditional Bmpr2 deletion in ECs, low-dose FK506 prevented exaggerated chronic hypoxic PAH associated with induction of EC targets of BMP signaling, such as apelin. Low-dose FK506 also reversed severe PAH in rats with medial hypertrophy following monocrotaline and in rats with neointima formation following VEGF receptor blockade and chronic hypoxia. Our studies indicate that low-dose FK506 could be useful in the treatment of PAH

Matemática Financiera-AF141-202101

El curso general en la carrera de Administración, de carácter teórico-práctico dirigido a los estudiantes del 3er ciclo, el curso introduce al alumno al mundo de las finanzas, proporcionándole las herramientas necesarias para el cálculo de resultados financieros que puede aplicar en el proceso de tomar decisiones de inversión y financiamiento