Depth and breadth of knowledge and the governance of technology alliances.

This paper focuses on technology alliances between R&D intensive biotechnology firms and larger pharmaceutical companies. It aims to investigate whether the biotech partners can leverage the depth and the breadth of their knowledge resources to retain their equity ownership when forming an alliance, and whether prior alliance experience adds to their overall leverage. Using a sample of 390 alliances formed between US biotechnology and pharmaceutical companies, we find that biotech firms with deeper technological resources are more likely to retain their equity ownership, and that this relationship is stronger when the biotech firm has more alliance experience

Improving a Satellite Mission System by means of a Semantic Grid Architecture

The use of a semantic grid architecture can make easier the deployment of complex applications, in which several organizations are involved and diverse resources are shared. This paper presents the application of the architecture defined in the Ontogrid project (S-OGSA) into a scenario for the analysis of the quality of the products of satellite missions

Chagas disease reactivation in a heart transplant patient infected by domestic Trypanosoma cruzi discrete typing unit I (TcIDOM)

Background Trypanosoma cruzi, causative agent of Chagas disease, displays high intraspecific genetic diversity: six genetic lineages or discrete typing units (DTUs) are currently recognized, termed TcI through TcVI. Each DTU presents a particular distribution pattern across the Americas, and is loosely associated with different transmission cycles and hosts. Several DTUs are known to circulate in Central America. It has been previously suggested that TcI infection is benign and does not lead to chronic chagasic cardiomyopathy (CCC). Findings In this study, we genotyped T. cruzi parasites circulating in the blood and from explanted cardiac tissue of an El Salvadorian patient who developed reactivation Chagas disease while on immunosuppressive medications after undergoing heart transplant in the U.S. as treatment for end-stage CCC. Parasite typing was performed through molecular methods (restriction fragment length polymorphism of polymerase reaction chain amplified products, microsatellite typing, maxicircle sequence typing and low-stringency single primer PCR, [LSSP-PCR]) as well as lineage-specific serology. We show that the parasites infecting the patient belong to the TcI DTU exclusively. Our data indicate that the parasites isolated from the patient belong to a genotype frequently associated with human infection throughout the Americas (TcI DOM ). Conclusions Our results constitute compelling evidence in support of TcI DTU’s ability to cause end-stage CCC and help dispel any residual bias that infection with this lineage is benign, pointing to the need for increased surveillance for dissemination of this genotype in endemic regions, the USA and globally

Prospectus, May 3, 1989

https://spark.parkland.edu/prospectus_1989/1010/thumbnail.jp

A Semantic Data Grid for Satellite Mission Quality Analysis

The combination of Semantic Web and Grid technologies and architectures cases the development of applications that share heterogeneous resource,, (data and computing elements) that belong to several organisations. The Aerospace domain has an extensive and heterogeneous network of facilities and institutions, with a strong need to share both data and computational resources for complex processing tasks. One such task is monitoring and data analysis for Satellite Missions. This paper presents a Semantic Data Grid for satellite missions, where flexibility, scalability, interoperability, extensibility and efficient development have been considered the key issues to be addressed

Resultados de los potenciales evocados miogénicos vestibulares en el vértigo posicional paroxístico benigno

Objective: Benign paroxysmal positional vertigo (BPPV) seems to occur because of otoconia migration into the semicircular canals or their adherence to the cupula. Although the origin of these otoconia lies in the macula of the utricle, vestibular evoked myogenic potentials (VEMPs) can be used assess saccular function. The aim of this study is to assess the saccular function in patients diagnosed with BPPV. Patients and method: Nineteen patients diagnosed with BPPV of the posterior semicircular canal were included in this study. Their auditory function and their caloric, rotatory chair, and VEMP responses were tested. Ipsilateral and contralateral VEMP thresholds, ipsilateral and contralateral p13 and n23 latencies at 100 dB, inter-peak amplitude and the interaural amplitude difference were determined. Results: We found a lack of VEMP response in 52 % of the ears with BPPV. When adjusted for bilateral absence, VEMP response was absent in 20.3 % of ears. Conclusions: Some patients with idiopathic BPPV show a degree of saccular dysfunction

Prospectus, February 8, 1989

https://spark.parkland.edu/prospectus_1989/1033/thumbnail.jp

Prospectus, January 31, 1990

https://spark.parkland.edu/prospectus_1990/1002/thumbnail.jp

Prospectus, September 21, 1989

https://spark.parkland.edu/prospectus_1989/1020/thumbnail.jp