23 research outputs found
Ototoxic reactions of quinine in healthy persons and patients with Plasmodium falciparum infection
Audiometric changes following quinine administration were studied in healthy Caucasian subjects and patients suffering from falciparum malaria disease. Quinine-dihydrochloride was administered intravenously as a single dose of 300 mg to 12 healthy subjects and as multiple doses of 600 mg in 4 h every 8 h in 10 Plasmodium falciparum malaria patients. The hearing function was monitored by conventional and high frequency audiometry. In nine healthy subjects hearing loss was documented at 2-4 h after infusion of Quinine-dihydrochloride at a mean maximal plasma quinine concentration of only 2 mg/l. In one healthy subject a persistent loss occurred of 20 dB at 14 kHz in one ear. In all malaria patients severe hearing losses and adverse effects related to ototoxicity were documented, but all the audiograms had returned to normal after 1 week and side effects disappeared. This study has shown that ototoxicity induced by quinine is almost completely reversible in healthy volunteers and in malaria patient
Serial indium-111-labelled IgG biodistribution in rat Pneumocystis carinii pneumonia: a tool to monitor the course and severity of the infection
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Cytokine profiles in bronchoalveolar lavage fluid and blood in HIV-seronegative patients with Pneumocystis carinii pneumonia
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23621___.pdf (publisher's version ) (Open Access
Detecting infection and inflammation with technetium-99m-labeled stealth liposomes
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4843.pdf (publisher's version ) (Open Access
Role of dipolar and exchange interactions in the positions and widths of EPR transitions for the single-molecule magnets Fe8 and Mn12
We examine quantitatively the temperature dependence of the linewidths and
line shifts in electron paramagnetic resonance experiments on single crystals
of the single-molecule magnets Fe and Mn, at fixed frequency, with
an applied magnetic field along the easy axis. We include inter-molecular
spin-spin interactions (dipolar and exchange) and distributions in both the
uniaxial anisotropy parameter and the Land\'{e} -factor. The temperature
dependence of the linewidths and the line shifts are mainly caused by the
spin-spin interactions. For Fe and Mn, the temperature dependence of
the calculated line shifts and linewidths agrees well with the trends of the
experimental data. The linewidths for Fe reveal a stronger temperature
dependence than those for Mn, because for Mn a much wider
distribution in overshadows the temperature dependence of the spin-spin
interactions. For Fe, the line-shift analysis suggests two competing
interactions: a weak ferromagnetic exchange coupling between neighboring
molecules and a longer-ranged dipolar interaction. This result could have
implications for ordering in Fe at low temperatures.Comment: published versio
Semiconductive and Photoconductive Properties of the Single Molecule Magnets Mn-Acetate and FeBr
Resistivity measurements are reported for single crystals of
Mn-Acetate and FeBr. Both materials exhibit a
semiconductor-like, thermally activated behavior over the 200-300 K range. The
activation energy, , obtained for Mn-Acetate was 0.37 0.05
eV, which is to be contrasted with the value of 0.55 eV deduced from the
earlier reported absorption edge measurements and the range of 0.3-1 eV from
intramolecular density of states calculations, assuming = , the
optical band gap. For FeBr, was measured as 0.73 0.1 eV,
and is discussed in light of the available approximate band structure
calculations. Some plausible pathways are indicated based on the crystal
structures of both lattices. For Mn-Acetate, we also measured
photoconductivity in the visible range; the conductivity increased by a factor
of about eight on increasing the photon energy from 632.8 nm (red) to 488 nm
(blue). X-ray irradiation increased the resistivity, but was insensitive
to exposure.Comment: 7 pages, 8 figure
Non-AIDS defining cancers in the D:A:D Study-time trends and predictors of survival : a cohort study
BACKGROUND:Non-AIDS defining cancers (NADC) are an important cause of morbidity and mortality in HIV-positive individuals. Using data from a large international cohort of HIV-positive individuals, we described the incidence of NADC from 2004-2010, and described subsequent mortality and predictors of these.METHODS:Individuals were followed from 1st January 2004/enrolment in study, until the earliest of a new NADC, 1st February 2010, death or six months after the patient's last visit. Incidence rates were estimated for each year of follow-up, overall and stratified by gender, age and mode of HIV acquisition. Cumulative risk of mortality following NADC diagnosis was summarised using Kaplan-Meier methods, with follow-up for these analyses from the date of NADC diagnosis until the patient's death, 1st February 2010 or 6 months after the patient's last visit. Factors associated with mortality following NADC diagnosis were identified using multivariable Cox proportional hazards regression.RESULTS:Over 176,775 person-years (PY), 880 (2.1%) patients developed a new NADC (incidence: 4.98/1000PY [95% confidence interval 4.65, 5.31]). Over a third of these patients (327, 37.2%) had died by 1st February 2010. Time trends for lung cancer, anal cancer and Hodgkin's lymphoma were broadly consistent. Kaplan-Meier cumulative mortality estimates at 1, 3 and 5 years after NADC diagnosis were 28.2% [95% CI 25.1-31.2], 42.0% [38.2-45.8] and 47.3% [42.4-52.2], respectively. Significant predictors of poorer survival after diagnosis of NADC were lung cancer (compared to other cancer types), male gender, non-white ethnicity, and smoking status. Later year of diagnosis and higher CD4 count at NADC diagnosis were associated with improved survival. The incidence of NADC remained stable over the period 2004-2010 in this large observational cohort.CONCLUSIONS:The prognosis after diagnosis of NADC, in particular lung cancer and disseminated cancer, is poor but has improved somewhat over time. Modifiable risk factors, such as smoking and low CD4 counts, were associated with mortality following a diagnosis of NADC
Cytokine responses in pneumocystis carinii pneumonia
Item does not contain fulltextK.U. Nijmegen, 2 december 1996Promotores : Pont, J.J.H.H.M. de, Grip, W.J. de
Co-promotores : Meer, J.W.M. van der, Sauerwein, R.W., Beckers, P.J.A
Cytokine responses in Pneumocystis carinii pneumonia
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mmubn000001_234349603.pdf (publisher's version ) (Open Access)Promotores : J. van der Meer, R. Sauerwein en P. Beckers100 p
Pro-inflammatory cytokines in lung and blood during steroid-induced Pneumocystis carinii pneumonia in rats
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22789___.PDF (publisher's version ) (Open Access