Effect of mesoporous silica under Neisseria meningitidis transformation process: environmental effects under meningococci transformation

<p>Abstract</p> <p>Background</p> <p>This study aimed the use of mesoporous silica under the naturally transformable <it>Neisseria meningitidis</it>, an important pathogen implicated in the genetic horizontal transfer of DNA causing a escape of the principal vaccination measures worldwide by the capsular switching process. This study verified the effects of mesoporous silica under <it>N. meningitidis </it>transformation specifically under the capsular replacement.</p> <p>Methods</p> <p>we used three different mesoporous silica particles to verify their action in <it>N. meningitis </it>transformation frequency.</p> <p>Results</p> <p>we verified the increase in the capsular gene replacement of this bacterium with the three mesoporous silica nanoparticles.</p> <p>Conclusion</p> <p>the mesouporous silica particles were capable of increasing the capsule replacement frequency in <it>N. meningitidis</it>.</p