58,022 research outputs found
A Prospective Analysis of Adverse Drug Reactions in a South Indian Hospital
Adverse drug reactions are a great cause of concern to the medical profession, the patients and the pharmaceutical industry. However ADR reporting and monitoring is yet to catch up in India. Hence we undertook a study to record and analyze adverse reactions among all patients admitted to the medical wards of a tertiary care. Centre patients admitted to all medical wards over one year were assessed for ADRs throughout their admission. Suspected ADRs were recorded and analyzed for i) the type of reaction ii) severity iii) Consequence on treatment that is if the drug was continued, or stopped, or needed to be treated with other drugs, iv) Physiological system involved and the v) group of the drugs associated with ADRs. Among 1250 patients admitted during the study period, 250 adverse events were observed. Majority (76.8%) were of mild type, 66% were severe requiring intensive care and 3 patients died. Antimicrobials were responsible for maximum (42.4%) ADRs followed by drugs acting on CNS (20%). When we analyzed the systems affected, CNS side effects were more common in our study. While in many other studies Cardiovascular and gastrointestinal side effects were the most common. Combination of drugs was responsible for a large percentage of ADRs. Inadvertent use of antipsychotics with sedatives led to respiratory failure in 4 patients of which 1 died. Contaminated IV fluids are suspected to be the cause of death in another fatal ADR. In conclusion there is a need for vigilant ADR monitoring to be done by all doctors to prevent morbidity and mortality from ADRs
Flatness-based control of a single qubit gate
This work considers the open-loop control problem of steering a two level
quantum system from an initial to a final condition. The model of this system
evolves on the state space SU(2), having two inputs that correspond to the
complex amplitude of a resonant laser field. A symmetry preserving flat output
is constructed using a fully geometric construction and quaternion
computations. Simulation results of this flatness-based open-loop control are
provided.Comment: Submitted to IEEE AC. Simulation code available at
http://cas.ensmp.fr/~rouchon/publications/PR2007/CodeMatlabScilabQubit.zi
A Time-Periodic Lyapunov Approach for Motion Planning of Controllable Driftless Systems on SU(n)
For a right-invariant and controllable driftless system on SU(n), we consider
a time-periodic reference trajectory along which the linearized control system
generates su(n): such trajectories always exist and constitute the basic
ingredient of Coron's Return Method. The open-loop controls that we propose,
which rely on a left-invariant tracking error dynamics and on a fidelity-like
Lyapunov function, are determined from a finite number of left-translations of
the tracking error and they assure global asymptotic convergence towards the
periodic reference trajectory. The role of these translations is to avoid being
trapped in the critical region of this Lyapunov-like function. The convergence
proof relies on a periodic version of LaSalle's invariance principle and the
control values are determined by numerical integration of the dynamics of the
system. Simulations illustrate the obtained controls for and the
generation of the C--NOT quantum gate.Comment: Submitte
Correctors for the Neumann problem in thin domains with locally periodic oscillatory structure
In this paper we are concerned with convergence of solutions of the Poisson
equation with Neumann boundary conditions in a two-dimensional thin domain
exhibiting highly oscillatory behavior in part of its boundary. We deal with
the resonant case in which the height, amplitude and period of the oscillations
are all of the same order which is given by a small parameter .
Applying an appropriate corrector approach we get strong convergence when we
replace the original solutions by a kind of first-order expansion through the
Multiple-Scale Method.Comment: to appear in Quarterly of Applied Mathematic
Valley polarization effects on the localization in graphene Landau levels
Effects of disorder and valley polarization in graphene are investigated in
the quantum Hall regime. We find anomalous localization properties for the
lowest Landau level (LL), where disorder can induce wavefunction delocalization
(instead of localization), both for white-noise and gaussian-correlated
disorder. We quantitatively identify the contribution of each sublattice to
wavefunction amplitudes. Following the valley (sublattice) polarization of
states within LLs for increasing disorder we show: (i) valley mixing in the
lowest LL is the main effect behind the observed anomalous localization
properties, (ii) the polarization suppression with increasing disorder depends
on the localization for the white-noise model, while, (iii) the disorder
induces a partial polarization in the higher Landau levels for both disorder
models.Comment: 5 pages, 6 figures, extended version, with 2 new figures adde
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