Resistensi Klebsiella SP terhadap Meropenem di RSUD Prof. Dr. Margono Soekarjo Purwokerto

Resistant Gram-negative bacteria, particularly Klebsiella sp., has become a serious problem in hospitals as one of the main causes of nosocomial infections spread through urine catheterization. Infections of Klebsiella sp. producing extended-spectrum beta-lactamase (ESBL) can lead to significant economic and clinical negative outcome. This study was aimed to determine the sensitivity of ESBL Klebsiella sp. against meropenem as a cause of nosocomial infections in Prof. Dr. Margono Soekarjo hospital. This research obtained urine samples from the urinary catheter of patients hospitalized for at least two days in the surgical ward and intensive care unit. ESBL examination conducted by the initial screen test, meanwhile, sensitivity test to meropenem done by using disk diffusion test. Among the 40 patients examined in this study 7.5% isolates were Klebsiella sp-positive. This research identified five percent of the total patients as ESBL positive with the level of sensitivity against meropenem was revealed as resistant

Peningkatan Penggunaan Antibiotik secara Bijak melalui Intervensi Alih Pengetahuan untuk Merubah Persepsi Masyarakat di Kabupaten Banyumas

IMPROVED USE OF ANTIBIOTIC BY USING TRANSFER OF KNOWLEDGE INTERVENTIONS TO CHANGE THE COMMUNITY PERCEPTION IN BANYUMAS DISTRICT. The use of antibiotics without indication by the medical community and the community became the trigger factor of increasing the incidence of antibiotic resistance in Indonesia. Meanwhile by 20150 antibiotic resistance is predictedto be the leading cause of death in the world. Community devotion was aimed at improving the understanding of society so that that is a change of perception about the use of antibiotic wisely. The target respondents of devotion consists of member of the family welfare empowerment group (PKK). A seriaes of activities undertaken were pre and post test to measure respondents' understanding of antibiotic use before and after intervention in the transfer of knowledge. The questionnaire used previously tested its validity by Pearson product moment test and its reliability by Alpha-Cronbach. The Sharpening of material obtained in knowledge transfer was done with role play and discussion. The result of T test analysis to score of quesionnaire before and after knowledge transfer showed significant p value (p = 0,049). The conclusion was that the transfer of knowledge can change the perception of PKK members about the wise use of antibiotics