47 research outputs found
Early-Morning and Late-Night Maximal Runs: Metabolic and Perceived Exertion Outcomes
People may exercise at the ends of their day to fit activity into their schedule; the purpose of this investigation was to determine if metabolic or perceived exertion outcomes differed between maximal runs early in the morning and late at night. After consuming a standardized, glucose drink, thirteen recreationally active individuals completed an early-morning and a late-night run on the treadmill while researchers measured metabolic (aerobic capacity and substrate usage) and perceived exertion outcomes. Point of application #1: Aerobic capacity (maximal consumption of oxygen) and the usage of fat as a fuel to support energy production during exercise were similar between runs. Point of application #2: Maximal perceived exertion (Borg’s 6-20) was similar during early-morning and late-night runs. Point of application #3: While research indicates that people may prefer activity in the morning or evening, and this might impact metabolic responses to the exercise bout, most of our participants (n=8) identified with no preference for exercising in the early-morning or late-night. Key Words: glucose; CHO shake; VO2max; fat oxidation; effor
Endothelial function and arterial stiffness in young adults with histories of chronic resistance activity
Endothelial dysfunction and arterial stiffness indicate vessel damage and are detectable before overt cardiovascular disease. Chronic cardiorespiratory endurance activity improves arterial endothelial function and stiffness. The influence of chronic resistance activity on these variables is less definitive and thus deserves attention. The primary aim of this investigation was to determine if endothelial dysfunction and arterial stiffness were present in apparently healthy young adults who chronically engage in resistance activity with minimal cardiorespiratory endurance activity. Investigators measured endothelial function as LnRHI and arterial stiffness as AI@75 using the EndoPAT-2000. Investigators measured upper-body muscular strength using a standardized one-repetition maximum (1-RM) bench press. The LnRHI and AI@75 between males and females were compared via an independent-samples t-test and Mann-Whitney U test, respectively. Correlations between 1-RM, bench press to body weight ratio, LnRHI, and AI@75 were evaluated via Pearson’s correlation. Males’ LnRHI was abnormal according to manufacturer standards and lower than females’ (p = .005), but AI@75 was normal and similar for both sexes (p = .22). The 1-RM and bench press to body weight ratio correlated negatively with LnRHI (p = .03 and p = .01, respectively). The bench press to body weight ratio correlated negatively with AI@75 (p = .03), and percentage body fat correlated positively with the AI@75 (p = .003). Young adult males with considerable upper-body muscular strength due to chronic resistance activity, who complete minimal cardiorespiratory endurance activity, appear to have detectable signs of early endothelial dysfunction
Efficacy and safety of teriparatide in improving fracture healing and callus formation:A systematic review
The PHENIX Experiment at RHIC
The physics emphases of the PHENIX collaboration and the design and current
status of the PHENIX detector are discussed. The plan of the collaboration for
making the most effective use of the available luminosity in the first years of
RHIC operation is also presented.Comment: 5 pages, 1 figure. Further details of the PHENIX physics program
available at http://www.rhic.bnl.gov/phenix
Visualization of <em>Candida albicans</em> in the Murine Gastrointestinal Tract Using Fluorescent In Situ Hybridization
Profiling and Qualitative Assessment of Enzymatically and Thermally Oxidized Egg Yolk Phospholipids using a Two‐Step High‐Performance Liquid Chromatography Protocol
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Candida albicans Morphogenesis Programs Control the Balance between Gut Commensalism and Invasive Infection
Candida albicans is a gut commensal and opportunistic pathogen. The transition between yeast and invasive hyphae is central to virulence but has unknown functions during commensal growth. In a mouse model of colonization, yeast and hyphae co-occur throughout the gastrointestinal tract. However, competitive infections of C. albicans homozygous gene disruption mutants revealed an unanticipated, inhibitory role for the yeast-to-hypha morphogenesis program on commensalism. We show that the transcription factor Ume6, a master regulator of filamentation, inhibits gut colonization, not by effects on cell shape, but by activating the expression of a hypha-specific pro-inflammatory secreted protease, Sap6, and a hyphal cell surface adhesin, Hyr1. Like a ume6 mutant, strains lacking SAP6 exhibit enhanced colonization fitness, whereas SAP6-overexpression strains are attenuated in the gut. These results reveal a tradeoff between fungal programs supporting commensalism and virulence in which selection against hypha-specific markers limits the disease-causing potential of this ubiquitous commensal-pathogen