1,084 research outputs found
Stochastic learning in a neural network with adapting synapses
We consider a neural network with adapting synapses whose dynamics can be
analitically computed. The model is made of neurons and each of them is
connected to input neurons chosen at random in the network. The synapses
are -states variables which evolve in time according to Stochastic Learning
rules; a parallel stochastic dynamics is assumed for neurons. Since the network
maintains the same dynamics whether it is engaged in computation or in learning
new memories, a very low probability of synaptic transitions is assumed. In the
limit with large and finite, the correlations of neurons and
synapses can be neglected and the dynamics can be analitically calculated by
flow equations for the macroscopic parameters of the system.Comment: 25 pages, LaTeX fil
Hierarchical Self-Programming in Recurrent Neural Networks
We study self-programming in recurrent neural networks where both neurons
(the `processors') and synaptic interactions (`the programme') evolve in time
simultaneously, according to specific coupled stochastic equations. The
interactions are divided into a hierarchy of groups with adiabatically
separated and monotonically increasing time-scales, representing sub-routines
of the system programme of decreasing volatility. We solve this model in
equilibrium, assuming ergodicity at every level, and find as our
replica-symmetric solution a formalism with a structure similar but not
identical to Parisi's -step replica symmetry breaking scheme. Apart from
differences in details of the equations (due to the fact that here
interactions, rather than spins, are grouped into clusters with different
time-scales), in the present model the block sizes of the emerging
ultrametric solution are not restricted to the interval , but are
independent control parameters, defined in terms of the noise strengths of the
various levels in the hierarchy, which can take any value in [0,\infty\ket.
This is shown to lead to extremely rich phase diagrams, with an abundance of
first-order transitions especially when the level of stochasticity in the
interaction dynamics is chosen to be low.Comment: 53 pages, 19 figures. Submitted to J. Phys.
Replica field theory and renormalization group for the Ising spin glass in an external magnetic field
We use the generic replica symmetric cubic field-theory to study the
transition of short range Ising spin glasses in a magnetic field around the
upper critical dimension, d=6. A novel fixed-point is found, in addition to the
well-known zero magnetic field fixed-point, from the application of the
renormalization group. In the spin glass limit, n going to 0, this fixed-point
governs the critical behaviour of a class of systems characterised by a single
cubic interaction parameter. For this universality class, the spin glass
susceptibility diverges at criticality, whereas the longitudinal mode remains
massive. The third mode, the so-called anomalous one, however, behaves
unusually, having a jump at criticality. The physical consequences of this
unusual behaviour are discussed, and a comparison with the conventional de
Almeida-Thouless scenario presented.Comment: 5 pages written in revtex4. Accepted for publication in Phys. Rev.
Let
The impact of bariatric surgery on serum tryptophan–kynurenine pathway metabolites
This study aims to explore the immediate effects of bariatric surgery on serum tryptophan–kynurenine pathway metabolites in individuals with type 2 diabetes and BMI > 30. With the goal of providing insight into the link between tryptophan pathway metabolites, type 2 diabetes, and chronic obesity-induced inflammation. This longitudinal study included 20 participants. Half were diagnosed with type 2 diabetes. 11 and 9 underwent RYGB and SG respectively. Blood samples were obtained at pre-operative and 3 months post-operative timepoints. Tryptophan and downstream metabolites of the kynurenine pathway were quantified with an ultrahigh-performance liquid chromatography tandem mass spectrometry with electrospray ionisation method. At 3 months post-operation, RYGB led to significant reductions in tryptophan, kynurenic acid and xanthurenic acid levels when compared to baseline. Significant reductions of the same metabolites after surgery were also observed in individuals with T2D irrespective of surgical procedure. These metabolites were significantly correlated with serum HbA1c levels and BMI. Bariatric surgery, in particular RYGB reduces serum levels of tryptophan and its downstream kynurenine metabolites. These metabolites are associated with T2D and thought to be potentially mechanistic in the systemic processes of obesity induced inflammation leading to insulin resistance. Its reduction after surgery is associated with an improvement in glycaemic control (HbA1c)
A solvable model of the genesis of amino-acid sequences via coupled dynamics of folding and slow genetic variation
We study the coupled dynamics of primary and secondary structure formation
(i.e. slow genetic sequence selection and fast folding) in the context of a
solvable microscopic model that includes both short-range steric forces and and
long-range polarity-driven forces. Our solution is based on the diagonalization
of replicated transfer matrices, and leads in the thermodynamic limit to
explicit predictions regarding phase transitions and phase diagrams at genetic
equilibrium. The predicted phenomenology allows for natural physical
interpretations, and finds satisfactory support in numerical simulations.Comment: 51 pages, 13 figures, submitted to J. Phys.
An inside story: tracking experiences, challenges and successes in a joint specialist performing arts college
In England the government’s specialist schools initiative is transforming the nature of secondary education. A three-year longitudinal case study tracked the effects of specialist performing arts college status on two schools. The sites were a mainstream school drawing pupils from an area of high social deprivation and disadvantage, and a special school catering for pupils with profound and \ud
multiple learning difficulties, which were awarded joint performing arts college status. The government’s \ud
preferred criterion for judging the success of specialist schools is improvement in whole-school examination results. The authors argue that this is a crude and inappropriate measure for these case study schools and probably others. Using questionnaires, interviews and documentation they tell an ‘inside story’ of experiences, challenges and achievements, from the perspectives of the schools’ mangers, staff and pupils. Alternative ‘value-added’ features emerged that were positive indicators of enrichment and success in both schools
Fission yeast 26S proteasome mutants are multi-drug resistant due to stabilization of the pap1 transcription factor
Here we report the result of a genetic screen for mutants resistant to the microtubule poison methyl benzimidazol-2-yl carbamate (MBC) that were also temperature sensitive for growth. In total the isolated mutants were distributed in ten complementation groups. Cloning experiments revealed that most of the mutants were in essential genes encoding various 26S proteasome subunits. We found that the proteasome mutants are multi-drug resistant due to stabilization of the stress-activated transcription factor Pap1. We show that the ubiquitylation and ultimately the degradation of Pap1 depend on the Rhp6/Ubc2 E2 ubiquitin conjugating enzyme and the Ubr1 E3 ubiquitin-protein ligase. Accordingly, mutants lacking Rhp6 or Ubr1 display drug-resistant phenotypes
Statistical mechanics of clonal expansion in lymphocyte networks modelled with slow and fast variables
We study the Langevin dynamics of the adaptive immune system, modelled by a
lymphocyte network in which the B cells are interacting with the T cells and
antigen. We assume that B clones and T clones are evolving in different thermal
noise environments and on different timescales. We derive stationary
distributions and use statistical mechanics to study clonal expansion of B
clones in this model when the B and T clone sizes are assumed to be the slow
and fast variables respectively and vice versa. We derive distributions of B
clone sizes and use general properties of ferromagnetic systems to predict
characteristics of these distributions, such as the average B cell
concentration, in some regimes where T cells can be modelled as binary
variables. This analysis is independent of network topologies and its results
are qualitatively consistent with experimental observations. In order to obtain
full distributions we assume that the network topologies are random and locally
equivalent to trees. The latter allows us to employ the Bethe-Peierls approach
and to develop a theoretical framework which can be used to predict the
distributions of B clone sizes. As an example we use this theory to compute
distributions for the models of immune system defined on random regular
networks.Comment: A more recent version (accepted for publication in Journal of Physics
A: Mathematical and Theoretical) with improved figures, references, et
Tales from the playing field: black and minority ethnic students' experiences of physical education teacher education
This article presents findings from recent research exploring black and minority ethnic (BME) students’ experiences of Physical Education teacher education (PETE) in England (Flintoff, 2008). Despite policy initiatives to increase the ethnic diversity of teacher education cohorts, BME students are under-represented in PETE, making up just 2.94% of the 2007/8 national cohort, the year in which this research was conducted. Drawing on in-depth interviews and questionnaires with 25 BME students in PETE, the study sought to contribute to our limited knowledge and understanding of racial and ethnic difference in PE, and to show how ‘race,’ ethnicity and gender are interwoven in individuals’ embodied, everyday experiences of learning how to teach. In the article, two narratives in the form of fictional stories are used to present the findings. I suggest that narratives can be useful for engaging with the experiences of those previously silenced or ignored within Physical Education (PE); they are also designed to provoke an emotional as well as an intellectual response in the reader. Given that teacher education is a place where we should be engaging students, emotionally and politically, to think deeply about teaching, education and social justice and their place within these, I suggest that such stories of difference might have a useful place within a critical PETE pedagogy
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