"Continuous" Backstepping of Holocene Coastal Barrier Systems into Incised Valleys: Insights from the Ofanto and Carapelle-Cervaro Valleys

Two recently recognised incised valleys in the Manfredonia Gulf are described. The first (CCV) is correlated with the current Carapelle and Cervaro streams. The second (OSFV) is correlated mostly with the current Ofanto River. Six seismic facies and seven unconformity-bounded seismic units have been identified, which infilled CCV and OSFV. In CCV, during the sea-level ranges from −29 to −18 and from −18 to −4.7 m b.s.l., two barrier/spit-backbarrier systems formed in the most landward sector of the valley. The lower system was attributed to a time interval between 9.2 ka BP and ca. 8.3 ka BP, chronologically constrained by the ZS2 borehole. In OSFV, during the sea level ranges from −39 to −29, and from −29 and to −18 m b.s.l., two beach/spit-backbarrier systems, arranged in a "continuous" landward backstepping pattern, formed. The phase that contributed most to the beach/spit-backbarrier systems formation is that which is coeval with the formation of the sapropel S1 in the Mediterranean. The conservation of barrier/spit-backbarrier systems arranged in a "continuous" landward backstepping pattern, is due to a strong and continued sediment supply that occurred during the sapropel S1 formation, coupled with low-gradient settings and a regime of slow sea-level rise

Gain-of-function mutations in the ALS8 causative gene VAPB have detrimental effects on neurons and muscles

Summary Amyotrophic Lateral Sclerosis (ALS) is a motor neuron degenerative disease characterized by a progressive, and ultimately fatal, muscle paralysis. The human VAMP-Associated Protein B (hVAPB) is the causative gene of ALS type 8. Previous studies have shown that a loss-of-function mechanism is responsible for VAPB-induced ALS. Recently, a novel mutation in hVAPB (V234I) has been identified but its pathogenic potential has not been assessed. We found that neuronal expression of the V234I mutant allele in Drosophila (DVAP-V260I) induces defects in synaptic structure and microtubule architecture that are opposite to those associated with DVAP mutants and transgenic expression of other ALS-linked alleles. Expression of DVAP-V260I also induces aggregate formation, reduced viability, wing postural defects, abnormal locomotion behavior, nuclear abnormalities, neurodegeneration and upregulation of the heat-shock-mediated stress response. Similar, albeit milder, phenotypes are associated with the overexpression of the wild-type protein. These data show that overexpressing the wild-type DVAP is sufficient to induce the disease and that DVAP-V260I is a pathogenic allele with increased wild-type activity. We propose that a combination of gain- and loss-of-function mechanisms is responsible for VAPB-induced ALS

Spatial evolution of the December 2013 Metaponto plain (Basilicata, Italy) flood event using multi-source and high-resolution remotely sensed data

We present a multi-layer, multi-temporal flood map of the event occurred on December 2013 in Basilicata (southern Italy), documenting the spatial evolution of the inundated areas through time, as well as some ground effects of floodwaters inferred from the imagery. The map, developed within a GIS and consisting of four, 1:20,000 scale, different layers, was prepared using image processing, visual image interpretation and field survey controls. We used two COSMO-SkyMed synthetic aperture radar (SAR) images, acquired during the event, and a Plèiades-1B High-Resolution optical image, acquired at the end of the event. We also used the information derived from the satellite imagery to update some local features of the OpenStreetMap (OSM) geospatial database, and then integrated it within the flood map. A classified multi-temporal dynamic map of inundation and flood effects has been produced in the form of a multi-layer pdf file (Main Map)

Rip current evidence by hydrodynamic simulations, bathymetric surveys and UAV observation

Abstract. The prediction of the formation, spacing and location of rip currents is a scientific challenge that can be achieved by means of different complementary methods. In this paper the analysis of numerical and experimental data, including RPAS (remotely piloted aircraft systems) observations, allowed us to detect the presence of rip currents and rip channels at the mouth of Sele River, in the Gulf of Salerno, southern Italy. The dataset used to analyze these phenomena consisted of two different bathymetric surveys, a detailed sediment analysis and a set of high-resolution wave numerical simulations, completed with Google EarthTM images and RPAS observations. The grain size trend analysis and the numerical simulations allowed us to identify the rip current occurrence, forced by topographically constrained channels incised on the seabed, which were compared with observations

Insight from an Italian Delphi Consensus on EVAR feasibility outside the instruction for use: the SAFE EVAR Study

BACKGROUND: The SAfety and FEasibility of standard EVAR outside the instruction for use (SAFE-EVAR) Study was designed to define the attitude of Italian vascular surgeons towards the use of standard endovascular repair (EVAR) for infrarenal abdominal aortic aneurysm (AAA) outside the instruction for use (IFU) through a Delphi consensus endorsed by the Italian Society of Vascular and Endovascular Surgery (Societa Italiana di Chirurgia Vascolare ed Endovascolare - SICVE). METHODS: A questionnaire consisting of 26 statements was developed, validated by an 18 -member Advisory Board, and then sent to 600 Italian vascular surgeons. The Delphi process was structured in three subsequent rounds which took place between April and June 2023. In the first two rounds, respondents could indicate one of the following five degrees of agreement: 1) strongly agree; 2) partially agree; 3) neither agree nor disagree; 4) partially disagree; 5) strongly disagree; while in the third round only three different choices were proposed: 1) agree; 2) neither agree nor disagree; 3) disagree. We considered the consensus reached when >70% of respondents agreed on one of the options. After the conclusion of each round, a report describing the percentage distribution of the answers was sent to all the participants. RESULTS: Two -hundred -forty-four (40.6%) Italian Vascular Surgeons agreed to participate the first round of the Delphi Consensus; the second and the third rounds of the Delphi collected 230 responders (94.3% of the first -round responders). Four statements (15.4%) reached a consensus in the first rounds. Among the 22 remaining statements, one more consensus (3.8%) was achieved in the second round. Finally, seven more statements (26.9%) reached a consensus in the simplified last round. Globally, a consensus was reached for almost half of the proposed statements (46.1%). CONCLUSIONS: The relatively low consensus rate obtained in this Delphi seems to confirm the discrepancy between Guideline recommendations and daily clinical practice. The data collected could represent the source for a possible guidelines' revision and the proposal of specific Good Practice Points in all those aspects with only little evidence available