Pairwise Instance Relation Augmentation for Long-tailed Multi-label Text Classification

Multi-label text classification (MLTC) is one of the key tasks in natural language processing. It aims to assign multiple target labels to one document. Due to the uneven popularity of labels, the number of documents per label follows a long-tailed distribution in most cases. It is much more challenging to learn classifiers for data-scarce tail labels than for data-rich head labels. The main reason is that head labels usually have sufficient information, e.g., a large intra-class diversity, while tail labels do not. In response, we propose a Pairwise Instance Relation Augmentation Network (PIRAN) to augment tailed-label documents for balancing tail labels and head labels. PIRAN consists of a relation collector and an instance generator. The former aims to extract the document pairwise relations from head labels. Taking these relations as perturbations, the latter tries to generate new document instances in high-level feature space around the limited given tailed-label instances. Meanwhile, two regularizers (diversity and consistency) are designed to constrain the generation process. The consistency-regularizer encourages the variance of tail labels to be close to head labels and further balances the whole datasets. And diversity-regularizer makes sure the generated instances have diversity and avoids generating redundant instances. Extensive experimental results on three benchmark datasets demonstrate that PIRAN consistently outperforms the SOTA methods, and dramatically improves the performance of tail labels

Low-Complexity Channel Estimation and Multi-User Detection for Uplink Grant-Free NOMA Systems

Grant-free non-orthogonal multiple access (NOMA) scheme is a promising candidate to accommodate massive connectivity with reduced signalling overhead for Internet of Things (IoT) services in massive machine-type communication (mMTC) networks. In this letter, we propose a low-complexity compressed sensing (CS) based sparsity adaptive block gradient pursuit (SA-BGP) algorithm in uplink grant-free NOMA systems. Our proposed SA-BGP algorithm is capable of jointly carrying out channel estimation (CE), user activity detection (UAD) and data detection (DD) without knowing the user sparsity level. By exploiting the inherent sparsity of transmission signal and gradient descend, our proposed method can enjoy a decent detection performance with substantial reduction of computational complexity. Simulation results demonstrate that the proposed method achieves a balanced trade-off between computational complexity and detection performance, rendering it a viable solution for future IoT applications

Low-Complexity Block Coordinate Descend Based Multiuser Detection for Uplink Grant-Free NOMA

Grant-free non-orthogonal multiple access (NOMA) scheme is considered as a promising candidate for the enabling of massive connectivity and reduced signalling overhead for Internet of Things (IoT) applications in massive machine-type communication (mMTC) networks. Exploiting the inherent nature of sporadic transmissions in the grant-free NOMA systems, compressed sensing based multiuser detection (CS-MUD) has been deemed as a powerful solution to user activity detection (UAD) and data detection (DD). In this paper, block coordinate descend (BCD) method is employed in CS-MUD to reduce the computational complexity. We propose two modified BCD based algorithms, called enhanced BCD (EBCD) and complexity reduction enhanced BCD (CR-EBCD), respectively. To be specific, by incorporating a novel candidate set pruning mechanism into the original BCD framework, our proposed EBCD algorithm achieves remarkable CS-MUD performance improvement. In addition, the proposed CR-EBCD algorithm further ameliorates the proposed EBCD by eliminating the redundant matrix multiplications during the iteration process. As a consequence, compared with the proposed EBCD algorithm, our proposed CR-EBCD algorithm enjoys two orders of magnitude complexity saving without any CS-MUD performance degradation, rendering it a viable solution for future mMTC scenarios. Extensive simulation results demonstrate the bound-approaching performance as well as ultra-low computational complexity

Population Genetic Diversity and Phylogenetic Characteristics for High-Altitude Adaptive Kham Tibetan Revealed by DNATyperTM 19 Amplification System

Tibetans residing in the high-altitude inhospitable environment have undergone significant natural selection of their genetic architecture. Recently, highly mutational autosomal short tandem repeats were widely used not only in the anthropology and population genetics to investigate the genetic structure and relationships, but also in the medical genetics to explore the pathogenesis of multiple genetic diseases and in the forensic science to identify individual and parentage relatedness. However, genetic variants and forensic efficiency of DNATyperTM 19 amplification system and genetic background of Kham Tibetan remain uncharacterized. Thus, we genotyped 19 forensic genetic markers in 11,402 Kham Tibetans to gain insight into the genetic diversity of Chinese high-altitude adaptive population. Highly discriminating and polymorphic forensic measures were observed, which indicated that this new-developed DNATyper 19 PCR amplification is suitable for routine forensic identification purposes and Chinese national DNA database establishment. Pairwise genetic distances among the comprehensive population comparisons suggested that this high-altitude adaptive Kham Tibetan has genetically closer relationships with lowlanders of Tibeto-Burman-speaking populations (Chengdu Tibetan, Liangshan Tibetan, and Liangshan Yi). Genetic substructure analyses via phylogenetic reconstruction, principal component analysis, and multidimensional scaling analysis in both nationwide and worldwide contexts suggested that the genetic proximity exists along the linguistic, ethnic, and continental geographical boundary. Further studies with whole-genome sequencing of modern or archaic Kham Tibetans would be useful in reconstructing the Tibetan population history

Deconfined quantum critical point lost in pressurized SrCu2(BO3)2

In the field of correlated electron materials, the relation between the resonating spin singlet and antiferromagnetic states has long been an attractive topic for understanding of the interesting macroscopic quantum phenomena, such as the ones emerging from magnetic frustrated materials, antiferromagnets and high-temperature superconductors. SrCu2(BO3)2 is a well-known quantum magnet, and it is theoretically expected to be the candidate of correlated electron material for clarifying the existence of a pressure-induced deconfined quantum critical point (DQCP), featured by a continuous quantum phase transition, between the plaquette-singlet (PS) valence bond solid phase and the antiferromagnetic (AF) phase. However, the real nature of the transition is yet to be identified experimentally due to the technical challenge. Here we show the experimental results for the first time, through the state-of-the-art high-pressure heat capacity measurement, that the PS-AF phase transition of the pressurized SrCu2(BO3)2 at zero field is clearly a first-order one. Our result clarifies the more than two-decade long debates about this key issue, and resonates nicely with the recent quantum entanglement understanding that the theoretically predicted DQCPs in representative lattice models are actually a first-order transition. Intriguingly, we also find that the transition temperatures of the PS and AF phase meet at the same pressure-temperature point, which signifies a bi-critical point as those observed in Fe-based superconductor and heavy-fermion compound, and constitutes the first experimental discovery of the pressure-induced bi-critical point in frustrated magnets. Our results provide fresh information for understanding the evolution among different spin states of correlated electron materials under pressure.Comment: 6 pages, 4 figure

Recent progress in the effect of ferroptosis of HSCs on the development of liver fibrosis

Fibrosis is a common pathological process that must take place for multiple chronic liver diseases to develop into cirrhosis and liver cancer. Liver fibrosis (LF) is regulated by various cytokines and signaling pathways in its occurrence and development. Ferroptosis is an important mode of cell death caused by iron-dependent oxidative damage and is regulated by iron metabolism and lipid peroxidation signaling pathways. In recent years, numerous studies have shown that ferroptosis is closely related to LF. As the main material secreted by the extracellular matrix, hepatic stellate cells (HSCs) are a general concern in the development of LF. Therefore, targeting HSC ferroptosis against LF is crucial. This review describes the current status of treating LF by inducing HSC ferroptosis that would aid studies in better understanding the current knowledge on ferroptosis in HSCs and the future research direction in this field

Pressure-induced coevolution of transport properties and lattice stability in CaK(Fe1-xNix)4As4 (x= 0.04 and 0) superconductors with and without spin-vortex crystal state

Here we report the first investigation on correlation between the transport properties and the corresponding stability of the lattice structure for CaK(Fe1-xNix)4As4 (x=0.04 and 0), a new type of putative topological superconductors, with and without a spin-vortex crystal (SVC) state in a wide pressure range involving superconducting to non-superconducting transition and the half- to full-collapse of tetragonal (h-cT and f-cT) phases, by the complementary measurements of high-pressure resistance, Hall coefficient and synchrotron X-ray diffraction. We identify the three critical pressures, P1 that is the turn-on critical pressure of the h-cT phase transition and it coincides with the critical pressure for the sign change of Hall coefficient from positive to negative, a manifestation of the Fermi surface reconstruction, P2 that is the turn-off pressures of the h-cT phase transition, and P3 that is the critical pressure of the f-cT phase transition. By comparing the high-pressure results measured from the two kinds of samples, we find a distinct left-shift of the P1 for the doped sample, at the pressure of which its SVC state is fully suppressed, however the P2 and the P3 remain the same as that of the undoped one. Our results not only provide a consistent understanding on the results reported before, but also demonstrate the importance of the Fe-As bonding in stabilizing the superconductivity of the iron pnictide superconductors through the pressure window

Robust magnetism against pressure in non-superconducting samples prepared from lutetium foil and H2/N2 gas mixture

Recently, the claim of "near-ambient superconductivity" in a N-doped lutetium hydride attracted enormous following-up investigations in the community of condensed matter physics and material sciences. But quite soon, the experimental results from different groups indicate consistently that no evidence of near-ambient superconductivity is found in the samples synthesized by the same method as the reported one, or by the other alternative methods. From our extended high-pressure heat capacity and magnetic susceptibility measurements on the samples prepared with the lutetium foil and H2/N2 gas mixture, we report the finding of a magnetic transition at the temperature about 56 K. Our results show that this magnetic phase is robust against pressure up to 4.3 GPa, which covers the critical pressure of boosting the claimed near room temperature superconductivity.Comment: 14 pages, 4 figure

Chitosan-salvianolic acid B coating on the surface of nickel-titanium alloy inhibits proliferation of smooth muscle cells and promote endothelialization

Introduction: Intracranial stents are of paramount importance in managing cerebrovascular disorders. Nevertheless, the currently employed drug-eluting stents, although effective in decreasing in-stent restenosis, might impede the re-endothelialization process within blood vessels, potentially leading to prolonged thrombosis development and restenosis over time.Methods: This study aims to construct a multifunctional bioactive coating to enhance the biocompatibility of the stents. Salvianolic acid B (SALB), a bioactive compound extracted from Salvia miltiorrhiza, exhibits potential for improving cardiovascular health. We utilized dopamine as the base and adhered chitosan-coated SALB microspheres onto nickel-titanium alloy flat plates, resulting in a multifunctional drug coating.Results: By encapsulating SALB within chitosan, the release period of SALB was effectively prolonged, as evidenced by the in vitro drug release curve showing sustained release over 28 days. The interaction between the drug coating and blood was examined through experiments on water contact angle, clotting time, and protein adsorption. Cellular experiments showed that the drug coating stimulates the proliferation, adhesion, and migration of human umbilical vein endothelial cells.Discussion: These findings indicate its potential to promote re-endothelialization. In addition, the bioactive coating effectively suppressed smooth muscle cells proliferation, adhesion, and migration, potentially reducing the occurrence of neointimal hyperplasia and restenosis. These findings emphasize the exceptional biocompatibility of the newly developed bioactive coating and demonstrate its potential clinical application as an innovative strategy to improve stent therapy efficacy. Thus, this coating holds great promise for the treatment of cerebrovascular disease

Comparative analysis of physiological variations and genetic architecture for cold stress response in soybean germplasm

Soybean (Glycine max L.) is susceptible to low temperatures. Increasing lines of evidence indicate that abiotic stress-responsive genes are involved in plant low-temperature stress response. However, the involvement of photosynthesis, antioxidants and metabolites genes in low temperature response is largely unexplored in Soybean. In the current study, a genetic panel of diverse soybean varieties was analyzed for photosynthesis, chlorophyll fluorescence and leaf injury parameters under cold stress and control conditions. This helps us to identify cold tolerant (V100) and cold sensitive (V45) varieties. The V100 variety outperformed for antioxidant enzymes activities and relative expression of photosynthesis (Glyma.08G204800.1, Glyma.12G232000.1), GmSOD (GmSOD01, GmSOD08), GmPOD (GmPOD29, GmPOD47), trehalose (GmTPS01, GmTPS13) and cold marker genes (DREB1E, DREB1D, SCOF1) than V45 under cold stress. Upon cold stress, the V100 variety showed reduced accumulation of H2O2 and MDA levels and subsequently showed lower leaf injury compared to V45. Together, our results uncovered new avenues for identifying cold tolerant soybean varieties from a large panel. Additionally, we identified the role of antioxidants, osmo-protectants and their posttranscriptional regulators miRNAs such as miR319, miR394, miR397, and miR398 in Soybean cold stress tolerance