A Woman\u27s Voice: Female Autobiography in the Nineteenth Century

Senior Project submitted to The Division of Social Studies of Bard College

The fortunes of King Lear in London between 1681 and 1838: A chronological account of its adaptors, actors and editors, and of the links between them

This thesis examines three interwoven strands in the dramatic and editorial history of King Lear between 1681 and 1838. One strand is the history of the adaptations which held the London stage during these years; the second is the changing styles of acting over the same period; the third is the work of the editors as they attempted to establish the Shakespearean text. This triple focus enables me to explore the paradoxical dominance of the adaptations at a time which saw both the text being edited for the first time and the rise of bardolatry. The three aspects of the fortunes of King Lear are linked in a number of ways, and I trace these connections as the editors, adaptors and actors concentrated on their own separate concerns. The thesis evolves chronologically. The arrival of the adaptations is discussed, each adaptation is examined, and the major revisions are noted as the adaptors shifted backwards and forwards towards a gradual return to Shakespeare's text and the final abandonment of the adaptations. The major productions of King Lear are explored, and I have included criticisms of the changing styles of acting among the players who were important in a King Lear role. The pioneering work of the editors and their growing confidence is studied and representative examples of their glosses and notes are offered. My final chapter draws together the links between the adaptors, actors and editors. It explores why Shakespeare, at a time when his reputation was in the ascendancy and whose plays were at the centre of developing skills in editing, nonetheless had many of these plays, represented in this thesis by King Lear, staged only in adaptation. I offer explanations for the initial interest in adaptations, why the audiences remained faithful to them and why they were finally abandoned

Direct linking of host rock deformation structures to the emplacement, morphology and accommodation of high-level igneous intrusions : the Henry Mountains, Utah

Most studies of magmatic intrusions concentrate on geometry and internal architecture: only a few pay particular attention to emplacement-related deformation structures in the host rock that record how magma is accommodated within the crust. This research aims to develop a greater understanding of how igneous intrusive bodies are emplaced and accommodated within the shallow crust, using classic exposures found in the Henry Mountains, Utah. Two satellite intrusions to the Mt Hillers intrusive centre show highly contrasting geometries, host-rock deformation and accommodation structures and apparent emplacement mechanisms. Trachyte Mesa, the most distal satellite intrusion of Mt Hillers, has a relatively simple elongate (NW-SE) geometry, concordant with the Entrada Sandstone it intrudes. The intrusion is comprised of multiple, stacked intrusive sheets. Syn-emplacement deformation structures observed in the host rocks consist of a conjugate set of intrusion margin-parallel deformation bands and extensional brittle faults, the latter occurring at the tips of intrusive sheets. These structures, along with a post¬emplacement set of intrusion margin parallel and perpendicular tensile joints, indicate extensional strain normal to the intrusion margin, consistent with a two-stage growth mechanism for individual sheets as well as the overall intrusion. In comparison, Maiden Creek shows a more complex intrusion geometry, including: lobate morphologies; steps and broken bridges; inclined sill sheets; and concave-upwards 'Iaccolithic' morphologies. A new model is proposed for the emplacement, evolution and final geometry of the intrusion, with a central elongate NE-SW lobe resulting from a principal north-easterly propagating magma flow. Lateral growth of the Maiden Creek intrusion resulted from radial spreading of magma from this main north-easterly flow trend towards the east and north-west. It is proposed that the southern Maiden Creek intrusion is comprised of two westerly-derived (saucer-shaped?) sills. Overlying these deeper-rooted sills is the newly identified Maiden Creek Shear Zone (MCSZ). This structure is an antithetic accommodation structure to magma flow. Substantial amounts of strain observed through microstructural analysis of shear zone samples suggest that the MCSZ played a critical role in accommodating magma emplacement. This study suggests that much can be learnt about intrusion geometries and emplacement mechanisms through detailed structural and kinematic analyses of the host rocks and intrusion-host rock contact

Ontogeny-based immunogens for the induction of V2-directed HIV broadly neutralizing antibodies.

CAPRISA, 2017.Abstract available in pdf

Correlating Gas Permeability and Young’s Modulus during the Physical Aging of Polymers of Intrinsic Microporosity Using Atomic Force Microscopy

The relationship, during physical aging, between the transport properties and Young’s modulus for films of polymers of intrinsic microporosity (PIM) was investigated using pure gas permeability and atomic force microscopy (AFM) in force spectroscopy mode. Excellent agreement of Young’s modulus measured for the archetypal PIM-1 with values obtained by other techniques in the literature, confirms the suitability of AFM force spectroscopy for the rapid and convenient assessment of mechanical properties. Results from different polymers including PIM-1 and five ultrapermeable benzotriptycene-based PIMs provide direct evidence that size selectivity is strongly correlated to Young’s modulus. In addition, film samples of one representative PIM (PIM-DTFM-BTrip) were subjected to both normal physical aging and to accelerated aging by thermal conditioning under vacuum for comparison. Accelerated aging resulted in a similar decrease in permeability and increase in Young’s modulus as normal aging, however, significant differences suggest that thermally induced accelerated aging occurs throughout the bulk of the polymer film whereas normal aging occurs predominantly at the surface of the film. For all PIMs, the increased in film rigidity upon aging led to an increase in gas size selectivity

The Relationship Between Physical Activity and Cardiorespiratory Fitness Among People Living With Human Immunodeficiency Virus Throughout The Life Span

BACKGROUND: People living with human immunodeficiency virus (PLHIV) are at an increased risk for developing cardiovascular disease (CVD). Physical activity and cardiorespiratory fitness in PLHIV are poorly understood. OBJECTIVE: The aims of this study were to describe physical activity and cardiorespiratory fitness by sex and age and to examine the association between physical activity and cardiorespiratory fitness in PLHIV, controlling for covariates. METHODS: Seven hundred two PLHIV participated in a cross-sectional study and completed validated measures of self-reported physical activity (7-day Physical Activity Recall) and cardiorespiratory fitness (6-minute walk test). Participants were recruited from 7 diverse sites in the United States and Thailand, and data were analyzed using descriptive statistics and multiple regression to examine the relationship between physical activity and cardiorespiratory fitness. RESULTS: On average, participants self-reported engaging in 115 minutes of, mostly light (75%), physical activity. Men reported twice the amount of physical activity as women (155 vs 73 minutes, P = .01). Participants\u27 ability to achieve their predicted 6-minute walk test distances was similar between men (68%) and women (69%) (P \u3e .01). For women, vigorous physical activity was associated with a 6.6% increase in cardiorespiratory fitness and being temporarily unemployed was associated with an 18% decline in cardiorespiratory fitness. Cardiorespiratory fitness increased with age (P \u3c .01). CONCLUSIONS: Weekly physical activity of people living with human immunodeficiency virus averaged 85 minutes of mostly light activity, well below the recommended 150 minutes of moderate activity. Vigorous physical activity was associated with improved cardiorespiratory fitness in women, but not men. Although PLHIV would benefit from interventions to increase physical activity, our data suggest a need to develop sex-specific physical activity strategies

Comprehensive quality assessment for aphasia rehabilitation after stroke: Protocol for a multicentre, mixed-methods study

INTRODUCTION: People with aphasia following stroke experience disproportionally poor outcomes, yet there is no comprehensive approach to measuring the quality of aphasia services. The Meaningful Evaluation of Aphasia SeRvicES (MEASuRES) minimum dataset was developed in partnership with people with lived experience of aphasia, clinicians and researchers to address this gap. It comprises sociodemographic characteristics, quality indicators, treatment descriptors and outcome measurement instruments. We present a protocol to pilot the MEASuRES minimum dataset in clinical practice, describe the factors that hinder or support implementation and determine meaningful thresholds of clinical change for core outcome measurement instruments. METHODS AND ANALYSIS: This research aims to deliver a comprehensive quality assessment toolkit for poststroke aphasia services in four studies. A multicentre pilot study (study 1) will test the administration of the MEASuRES minimum dataset within five Australian health services. An embedded mixed-methods process evaluation (study 2) will evaluate the performance of the minimum dataset and explore its clinical applicability. A consensus study (study 3) will establish consumer-informed thresholds of meaningful change on core aphasia outcome constructs, which will then be used to establish minimal important change values for corresponding core outcome measurement instruments (study 4). ETHICS AND DISSEMINATION: Studies 1 and 2 have been registered with the Australian and New Zealand Clinical Trial Registry (ACTRN12623001313628). Ethics approval has been obtained from the Royal Brisbane and Women\u27s Hospital (HREC/2023/MNHB/95293) and The University of Queensland (2022/HE001946 and 2023/HE001175). Study findings will be disseminated through peer-reviewed publications, conference presentations and engagement with relevant stakeholders including healthcare providers, policy-makers, stroke and rehabilitation audit and clinical quality registry custodians, consumer support organisations, and individuals with aphasia and their families

Spatial effects of mosquito bednets on child mortality

<p>Abstract</p> <p>Background</p> <p>Insecticide treated nets (ITN) have been proven to be an effective tool in reducing the burden of malaria. Few randomized clinical trials examined the spatial effect of ITNs on child mortality at a high coverage level, hence it is essential to better understand these effects in real-life situation with varying levels of coverage. We analyzed for the first time data from a large follow-up study in an area of high perennial malaria transmission in southern Tanzania to describe the spatial effects of bednets on all-cause child mortality.</p> <p>Methods</p> <p>The study was carried out between October 2001 and September 2003 in 25 villages in Kilombero Valley, southern Tanzania. Bayesian geostatistical models were fitted to assess the effect of different bednet density measures on child mortality adjusting for possible confounders.</p> <p>Results</p> <p>In the multivariate model addressing potential confounding, the only measure significantly associated with child mortality was the bed net density at household level; we failed to observe additional community effect benefit from bed net coverage in the community.</p> <p>Conclusion</p> <p>In this multiyear, 25 village assessment, despite substantial known inadequate insecticide-treatment for bed nets, the density of household bed net ownership was significantly associated with all cause child mortality reduction. The absence of community effect of bednets in our study area might be explained by (1) the small proportion of nets which are treated with insecticide, and (2) the relative homogeneity of coverage with nets in the area. To reduce malaria transmission for both users and non-users it is important to increase the ITNs and long-lasting nets coverage to at least the present untreated nets coverage.</p