Automatic Morphological Analysis of Medial Temporal Lobe

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Analysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy

Because hyper-excitability has been shown to be a shared pathophysiological mechanism, we used the latest and largest genome-wide studies in amyotrophic lateral sclerosis (n = 36,052) and epilepsy (n = 38,349) to determine genetic overlap between these conditions. First, we showed no significant genetic correlation, also when binned on minor allele frequency. Second, we confirmed the absence of polygenic overlap using genomic risk score analysis. Finally, we did not identify pleiotropic variants in meta-analyses of the 2 diseases. Our findings indicate that amyotrophic lateral sclerosis and epilepsy do not share common genetic risk, showing that hyper-excitability in both disorders has distinct origins

L. Boltzmann alla nascita della meccanica statistica

The celebrated papers giving rise to statistical mechanics that L. Boltzmann wrote between 1868 and 1877, are based on two fundamental presuppositions: first, statistical mechanics is a probabilistic theory; second, each probability distribution must be characterised in finitary terms, especially probability densities. Moreover an accurate analysis of these papers shows that Boltzmann used distributions which were unknown to contemporary statisticians, for example Beta and Gamma distributions, and that he was well aware of convergences in distribution binding them

Volume properties of the hippocampal regions as predictors of DAT development

In this work we look at the statistical distribution of geometrical observables computed in volumes centered on the right and left hippocampus in MR images. The observable distributions are then correlated with the clinical diagnosis in patients potentially affected by the Alzheimer disease. We then evaluate the discrimination ability of the geometrical observables combined with the MMSE test results

Dose-Dense Nonpegylated Liposomal Doxorubicin and Docetaxel Combination in Breast Cancer: Dose-Finding Study AUTHOR SUMMARY

ABSTRACT Background. Anthracyclines and taxanes are effective drugs in breast cancer (BC), but their toxicity profiles limit their use in combination. A dose-finding study was performed to determine maximum tolerated doses (MTDs) of nonpegylated liposomal doxorubicin (TLC-D99) and docetaxel (DTX) as a dose-dense schedule, to maintain dose intensity, and to limit toxicity, particularly cardiac. Methods. Twenty-four patients were enrolled, 12 with metastatic BC, 5 with locally advanced BC, and 7 with early BC. An intra-and interpatient approach was planned in two sequential steps. In the first step,TLC-D99 was administered at dose levels of 40, 45, and 50 mg/m 2 plus DTX at a fixed dose of 50 mg/m 2 . In the second step,TLC-D99 was administered at the dose established in the first step plus DTX at dose levels of 55, 60, and 65 mg/m 2 . Every treatment cycle was delivered on day 1 every 14 days. Pegylated granulocyte colony-stimulating factor was scheduled on day 2. Dose-limiting toxicities (DLTs) were defined as G4 hematological; G3 nonhematological; $10$20% left ventricular ejection fraction (LVEF) reduction if the final value was ,50% or $50$20% LVEF reduction in 1 patient and symptomatic arrhythmia in another; 2 incidences of G4 neutropenia (8.3%); and 1 occurrence of G3 asthenia (4.2%) were reported. MTDs were not reached. The recommended doses were established as TLC-D99 50 mg/