287 research outputs found
Neutrino propagation in matter using the wave packet approach
We study the oscillations and conversions of relativistic neutrinos
propagating in matter of variable density using the wave packet formalism. We
show how the oscillation and coherence lengths are modified in comparison with
the case of oscillations in vacuum. Secondly, we demonstrate how the equation
of motion for two neutrino flavors can be formally solved for almost arbitrary
density profile. We calculate finally how the use of wave packets alters the
nonadiabatic level crossing probabilities. For the most common physical
environments the corrections due to the width of the wave packet do not lead to
observable effects.Comment: 21 pages, LATEX, no figure
Supernova bound on keV-mass sterile neutrinos reexamined
Active-sterile neutrino mixing is strongly constrained for m_s > 100 keV to
avoid excessive energy losses from supernova cores. For smaller m_s, matter
effects suppress the effective mixing angle except for a resonant range of
energies where it is enhanced. We study the case of \nu_tau-\nu_s-mixing where
a \nu_tau-\bar\nu_tau asymmetry builds up due to the strong excess of \nu_s
over \bar\nu_s emission or vice versa, reducing the overall emission rate. In
the warm dark matter range m_s < 10 keV the mixing angle is essentially
unconstrained.Comment: 6 pages, 4 figures; minor changes, references updated, matches the
published versio
Measurements of muon flux in the Pyh\"asalmi underground laboratory
The cosmic-ray induced muon flux was measured at several depths in the
Pyh\"asalmi mine (Finland) using a plastic scintillator telescope mounted on a
trailer. The flux was determined at four different depths underground at 400 m
(980 m.w.e), at 660 m (1900 m.w.e), at 990 m (2810 m.w.e) and at 1390 m (3960
m.w.e) with the trailer, and also at the ground surface. In addition,
previously measured fluxes from depths of 90 m (210 m.w.e) and 210 m (420
m.w.e) are shown. A relation was obtained for the underground muon flux as a
function of the depth. The measured flux follows well the general behaviour and
is consistent with results determined in other underground laboratories.Comment: 8 pages, 2 figures. Submitted to Nuclear Instrum. Methods
Semimechanistic Population Pharmacokinetic Model to Predict the Drug-Drug Interaction Between S-ketamine and Ticlopidine in Healthy Human Volunteers
Low-dose oral S-ketamine is increasingly used in chronic pain therapy, but extensive cytochrome P450 (CYP) mediated metabolism makes it prone to pharmacokinetic drug-drug interactions (DDIs). In our study, concentration-time data from five studies were used to develop a semimechanistic model that describes the ticlopidine-mediated inhibition of S-ketamine biotransformation. A mechanistic model was implemented to account for reversible and time-dependent hepatic CYP2B6 inactivation by ticlopidine, which causes elevated S-ketamine exposure in vivo. A pharmacokinetic model was developed with gut wall and hepatic clearances for S-ketamine, its primary metabolite norketamine, and ticlopidine. Nonlinear mixed effects modeling approach was used (NONMEM version 7.3.0), and the final model was evaluated with visual predictive checks and the sampling-importance-resampling procedure. Our final model produces biologically plausible output and demonstrates that ticlopidine is a strong inhibitor of CYP2B6 mediated S-ketamine metabolism. Simulations from our model may be used to evaluate chronic pain therapy with S-ketamine.Peer reviewe
Neutrino Mass Texture with Large Mixing
We propose a simple texture for the right-handed Majorana mass matrix to give
a large mixing angle and hierarchical left-handed neutrino
mass pattern. Consistently with the Dirac mass texture of the quark sector
realizing the CKM mixing, this naturally explains the recent experimental
results on both the atmospheric neutrino anomaly observed by the
Superkamiokande collaboration and the solar neutrino problem. In this texture
the right-handed Majorana mass of the third generation is of the order of GUT
scale, which is favorable for reproducing the observed bottom-tau mass ratio.Comment: 10 pages, LaTeX, comments and references adde
Light Unstable Sterile Neutrino
The three massless active (doublet) neutrinos may mix with two heavy and one
\underline {light} sterile (singlet) neutrinos so that the induced masses and
mixings among the former are able to explain the present data on atmospheric
and solar neutrino oscillations. If the LSND result is also to be explained,
one active neutrino mass eigenstate must mix with the light sterile neutrino. A
specific model is proposed with the spontaneous and soft explicit breaking of a
new global symmetry so that a sterile neutrino will decay into an
active antineutrino and a nearly massless pseudo-Majoron.Comment: Discussion and references adde
A Mass Matrix for Atmospheric, Solar, and LSND Neutrino Oscillations
We construct a mass matrix for the four neutrino flavors, three active and
one sterile, needed to fit oscillations in all three neutrino experiments:
atmospheric, solar, and LSND, simultaneously. It organizes the neutrinos into
two doublets whose central values are about 1 eV apart, and whose splittings
are of the order of 10^(-3) eV. Atmospheric neutrino oscillations are described
as maximal mixing within the upper doublet, and solar as the same within the
lower doublet. Then LSND is a weak transition from one doublet to the other. We
comment on the Majorana versus Dirac nature of the active neutrinos and show
that our mass matrix can be derived from an S_2 x S_2 permutation symmetry plus
an equal splitting rule.Comment: 4 pages, 0 figures, minor text change
Spin-Flavour Oscillations and Neutrinos from SN1987A
The neutrino signal from SN1987A is analysed with respect to spin-flavour
oscillations between electron antineutrinos, , and muon
neutrinos, , by means of a maximum likelihood analysis.
Following Jegerlehner et al. best fit values for the total energy released in
neutrinos, , and the temperature of the electron antineutrino,
, for a range of mixing parameters and progenitor models are
calculated. In particular the dependence of the inferred quantities on the
metallicity of the supernova is investigated and the uncertainties involved in
using the neutrino signal to determine the neutrino magnetic moment are pointed
out.Comment: 14 pages, RevTeX, 4 figures, to appear in Physical Review
Neutrino mass spectrum and neutrinoless double beta decay
The relations between the effective Majorana mass of the electron neutrino,
, responsible for neutrinoless double beta decay, and the neutrino
oscillation parameters are considered. We show that for any specific
oscillation pattern can take any value (from zero to the existing
upper bound) for normal mass hierarchy and it can have a minimum for inverse
hierarchy. This means that oscillation experiments cannot fix in general
. Mass ranges for can be predicted in terms of oscillation
parameters with additional assumptions about the level of degeneracy and the
type of hierarchy of the neutrino mass spectrum. These predictions for
are systematically studied in the specific schemes of neutrino mass and flavor
which explain the solar and atmospheric neutrino data. The contributions from
individual mass eigenstates in terms of oscillation parameters have been
quantified. We study the dependence of on the non-oscillation
parameters: the overall scale of the neutrino mass and the relative mass
phases. We analyze how forthcoming oscillation experiments will improve the
predictions for . On the basis of these studies we evaluate the
discovery potential of future \znbb decay searches. The role \znbb decay
searches will play in the reconstruction of the neutrino mass spectrum is
clarified. The key scales of , which will lead to the discrimination
among various schemes are: eV and eV.Comment: 47 pages, 35 figure
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