Spectral analysis of the Forbush decrease of 13 July 1982

The maximum entropy method has been applied in the spectral analysis of high-energy cosmic-ray intensity during the large Forbush event of July 13, 1982. An oscillation with period of about 2 hours and amplitude of 1 to 3% was found to be present during the decrease phase. This oscillation can be related to a similar periodicity in the magnetospheric field. However, the variation was not observed at all neutron monitor stations. In the beginning of the recovery phase, the intensity oscillated with a period of about 10 hours and amplitude of 3%

Origin of Hysteresis in a Proximity Josephson Junction

We investigate hysteresis in the transport properties of Superconductor - Normal metal - Superconductor (S-N-S) junctions at low temperatures by measuring directly the electron temperature in the normal metal. Our results demonstrate unambiguously that the hysteresis results from an increase of the normal metal electron temperature once the junction switches to the resistive state. In our geometry, the electron temperature increase is governed by the thermal resistance of the superconducting electrodes of the junction

A facility for investigation of multiple hadrons at cosmic-ray energies

An experimental arrangement for studying multiple hadrons produced in high-energy hadron-nucleus interactions is under construction at the university of Turku. The method of investigation is based on the detection of hadrons arriving simultaneously at sea level over an area of a few square meters. The apparatus consists of a hadron spectrometer with position-sensitive detectors in connection with a small air shower array. The position resolution using streamer tube detectors will be about 10 mm. Energy spectra of hadrons or groups of simultaneous hadrons produced at primary energies below 10 to the 16th power eV can be measured in the energy range 1 to 2000 GeV

Observations of cosmic-ray modulations in the fall, 1984

Modulation of cosmic-ray energy spectrum was studied by using the Turku double neutron monitor. The multiplicity region of detected neutrons produced by cosmic ray hadrons in the monitor was divided into seven categories corresponding to mean energies 0.1, 0.3, 1.0, 3.2, 8.6, 21, and 94 GeV of hadrons at sea level. Based on 24-hour frequencies, a statistical analysis showed that modulation of the intensity in all categories occurred during several periods in the fall 1984. The magnitude of the variation was a few per cent

Investigation of cosmic rays in very short time scales

A fast databuffer system, where cosmic ray events in the Turku hadron spectrometer, including particle arrival times are recorded with time resolution of 100 ns was constructed. The databuffer can be read continuously by a microprocessor, which preanalyzes the data and transfers it to the main computer. The time span, that can be analyzed in every detail, is a few seconds. The high time resolution enables a study of time correlated groups of high energy particles. In addition the operational characteristics of the spectrometer can be monitored in detail

Degrees of order : A comparison of nanocrystal and amorphous solids for poorly soluble drugs

Poor aqueous solubility is currently a prevalent issue in the development of small molecule pharmaceuticals. Several methods are possible for improving the solubility, dissolution rate and bioavailability of Biopharmaceutics Classification System (BCS) class II and class IV drugs. Two solid state approaches, which rely on reductions in order, and can theoretically be applied to all molecules without any specific chemical prerequisites (compared with e.g. ionizable or co-former groups, or sufficient lipophilicity), are the use of the amorphous form and nanocrystals. Research involving these two approaches is relatively extensive and commercial products are now available based on these technologies. Nevertheless, their formulation remains more challenging than with conventional dosage forms. This article describes these two technologies from both theoretical and practical perspectives by briefly discussing the physicochemical backgrounds behind these approaches, as well as the resulting practical implications, both positive and negative. Case studies demonstrating the benefits and challenges of these two techniques are presented.Peer reviewe

Thermal conductance of a proximity superconductor

We study heat transport in hybrid normal metal - superconductor - normal metal (NSN) structures. We find the thermal conductance of a short superconducting wire to be strongly enhanced beyond the BCS value due to inverse proximity effect. The measurements agree with a model based on the quasiclassical theory of superconductivity in the diffusive limit. We determine a crossover temperature below which quasiparticle heat conduction dominates over the electron-phonon relaxation.Comment: 4+ pages, 3 figure