Precision Predictions at N3^3LO for the Higgs Boson Rapidity Distribution at the LHC

We present precise predictions for the Higgs boson rapidity distribution at the LHC in the gluon fusion production mode. Our approach relies on the fully analytic computation of six terms in a systematic expansion of the partonic differential cross section around the production threshold of the Higgs boson at next-to-next-to-next-to leading order (N$^3$LO) in QCD perturbation theory. We observe a mild correction compared to the previous perturbative order and a significant reduction of the dependence of the cross section on the perturbative scale throughout the entire rapidity range.Comment: 6 pages, 3 awesome figure

Differential Higgs production at N3LO beyond threshold

We present several key steps towards the computation of differential Higgs boson cross sections at N$^3$LO in perturbative QCD. Specifically, we work in the framework of Higgs-differential cross sections that allows to compute precise predictions for realistic LHC observables. We demonstrate how to perform an expansion of the analytic N$^3$LO coefficient functions around the production threshold of the Higgs boson. Our framework allows us to compute to arbitrarily high order in the threshold expansion and we explicitly obtain the first two expansion coefficients in analytic form. Furthermore, we assess the phenomenological viability of threshold expansions for differential distributions. In addition, we report on an interesting obstacle for the computation of N$^3$LO corrections with LHAPDF parton distribution functions and our solution. We provide files containing the analytic expressions for the partonic cross sections together with the arXiv submission.Comment: 12 plots and 1 Feynman Diagra

Higgs-differential cross section at NNLO in dimensional regularisation

We present an analytic computation of the Higgs production cross section in the gluon fusion channel, which is differential in the components of the Higgs momentum and inclusive in the associated partonic radiation through NNLO in perturbative QCD. Our computation includes the necessary higher order terms in the dimensional regulator beyond the finite part that are required for renormalisation and collinear factorisation at N$^3$LO. We outline in detail the computational methods which we employ. We present numerical predictions for realistic final state observables, specifically distributions for the decay products of the Higgs boson in the $\gamma\gamma$ decay channel.Comment: 27 pages, 6 awesome figure

Numerical Loop-Tree Duality: contour deformation and subtraction

We introduce a novel construction of a contour deformation within the framework of Loop-Tree Duality for the numerical computation of loop integrals featuring threshold singularities in momentum space. The functional form of our contour deformation automatically satisfies all constraints without the need for fine-tuning. We demonstrate that our construction is systematic and efficient by applying it to more than 100 examples of finite scalar integrals featuring up to six loops. We also showcase a first step towards handling non-integrable singularities by applying our work to one-loop infrared divergent scalar integrals and to the one-loop amplitude for the ordered production of two and three photons. This requires the combination of our contour deformation with local counterterms that regulate soft, collinear and ultraviolet divergences. This work is an important step towards computing higher-order corrections to relevant scattering cross-sections in a fully numerical fashion.Comment: 87 page

Sperm glyceraldehyde 3-phosphate dehydrogenase gene expression in asthenozoospermic spermatozoa

It has been suggested that the energy required for sperm motility is produced by oxidative phosphorylation while glycolysis seems to be an important source for ATP transmission along the flagellum. Some studies have investigated the chemical and kinetic properties of the enzyme glyceraldehyde 3‐phosphate dehydrogenase to identify any changes in the regulation of glycolysis and sperm motility. In contrast, there are few studies analyzing the genetic basis of hypokinesis. For this reason, we investigated the glyceraldehyde 3‐phosphate dehydrogenase gene in human sperm to evaluate whether asthenozoospermia was correlated with any changes in its expression. Semen examination and glyceraldehyde 3‐phosphate dehydrogenase gene expression studies were carried out on 116 semen samples divided into two groups – Group A consisted of 58 normokinetic samples and Group B of 58 hypokinetic samples. Total RNA was extracted from spermatozoa, and real‐time PCR quantification of mRNA was carried out using specific primers and probes. The expression profiles for the Groups A and B were very similar. The mean delta Ct was as follows – Group A, 5.79 ± 1.04; Group B, 5.47 ± 1.27. Our study shows that in human sperm, there is no difference in glyceraldehyde 3‐phosphate dehydrogenase gene expression between samples with impaired motility and samples with normal kinetics. We believe that this study could help in the understanding of the molecular mechanisms of sperm kinetics, suggesting that hypomotility may be due to a possible posttranscriptional impairment of the control mechanism, such as mRNA splicing, or to posttranslational changes

Local Unitarity: a representation of differential cross-sections that is locally free of infrared singularities at any order

We propose a novel representation of differential scattering cross-sections that locally realises the direct cancellation of infrared singularities exhibited by its so-called real-emission and virtual degrees of freedom. We take advantage of the Loop-Tree Duality representation of each individual forward-scattering diagram and we prove that the ensuing expression is locally free of infrared divergences, applies at any perturbative order and for any process without initial-state collinear singularities. Divergences for loop momenta with large magnitudes are regulated using local ultraviolet counterterms that reproduce the usual Lagrangian renormalisation procedure of quantum field theories. Our representation is especially suited for a numerical implementation and we demonstrate its practical potential by computing fully numerically and without any IR counterterm the next-to-leading order accurate differential cross-section for the process $e^+ e^- \rightarrow d \bar{d}$. We also show first results beyond next-to-leading order by computing interference terms part of the N4LO-accurate inclusive cross-section of a $1\rightarrow 2+X$ scalar scattering process.Comment: 88 page

Management of acute diverticulitis with pericolic free gas (ADIFAS). an international multicenter observational study

Background: There are no specific recommendations regarding the optimal management of this group of patients. The World Society of Emergency Surgery suggested a nonoperative strategy with antibiotic therapy, but this was a weak recommendation. This study aims to identify the optimal management of patients with acute diverticulitis (AD) presenting with pericolic free air with or without pericolic fluid. Methods: A multicenter, prospective, international study of patients diagnosed with AD and pericolic-free air with or without pericolic free fluid at a computed tomography (CT) scan between May 2020 and June 2021 was included. Patients were excluded if they had intra-abdominal distant free air, an abscess, generalized peritonitis, or less than a 1-year follow-up. The primary outcome was the rate of failure of nonoperative management within the index admission. Secondary outcomes included the rate of failure of nonoperative management within the first year and risk factors for failure. Results: A total of 810 patients were recruited across 69 European and South American centers; 744 patients (92%) were treated nonoperatively, and 66 (8%) underwent immediate surgery. Baseline characteristics were similar between groups. Hinchey II-IV on diagnostic imaging was the only independent risk factor for surgical intervention during index admission (odds ratios: 12.5, 95% CI: 2.4-64, P =0.003). Among patients treated nonoperatively, at index admission, 697 (94%) patients were discharged without any complications, 35 (4.7%) required emergency surgery, and 12 (1.6%) percutaneous drainage. Free pericolic fluid on CT scan was associated with a higher risk of failure of nonoperative management (odds ratios: 4.9, 95% CI: 1.2-19.9, P =0.023), with 88% of success compared to 96% without free fluid ( P <0.001). The rate of treatment failure with nonoperative management during the first year of follow-up was 16.5%. Conclusion: Patients with AD presenting with pericolic free gas can be successfully managed nonoperatively in the vast majority of cases. Patients with both free pericolic gas and free pericolic fluid on a CT scan are at a higher risk of failing nonoperative management and require closer observation

Diversity and ethics in trauma and acute care surgery teams: results from an international survey

Background Investigating the context of trauma and acute care surgery, the article aims at understanding the factors that can enhance some ethical aspects, namely the importance of patient consent, the perceptiveness of the ethical role of the trauma leader, and the perceived importance of ethics as an educational subject. Methods The article employs an international questionnaire promoted by the World Society of Emergency Surgery. Results Through the analysis of 402 fully filled questionnaires by surgeons from 72 different countries, the three main ethical topics are investigated through the lens of gender, membership of an academic or non-academic institution, an official trauma team, and a diverse group. In general terms, results highlight greater attention paid by surgeons belonging to academic institutions, official trauma teams, and diverse groups. Conclusions Our results underline that some organizational factors (e.g., the fact that the team belongs to a university context or is more diverse) might lead to the development of a higher sensibility on ethical matters. Embracing cultural diversity forces trauma teams to deal with different mindsets. Organizations should, therefore, consider those elements in defining their organizational procedures. Level of evidence Trauma and acute care teams work under tremendous pressure and complex circumstances, with their members needing to make ethical decisions quickly. The international survey allowed to shed light on how team assembly decisions might represent an opportunity to coordinate team member actions and increase performance