Molecular epigenetics, chromatin, and NeuroAIDS/HIV: Translational implications

We describe current research that applies epigenetics to a novel understanding of the immuno-neuropathogenesis of HIV-1 viral infection and NeuroAIDS. We propose the hypothesis that HIV-1 alters the structure-function relationship of chromatin, coding DNA and non-coding DNA, including RNA transcribed from these regions resulting in pathogenesis in AIDS, drug abuse, and NeuroAIDS. We discuss the general implications of molecular epigenetics with special emphasis on drug abuse, bar-codes, pyknons, and miRNAs for translational and clinical research. We discuss the application of the recent recursive algorithm of biology to this field and propose to synthesize the Genomic and Epigenomic views into a holistic approach of HoloGenomics

Change in pattern of muscle activity following botulinum toxin injections for torticollis

Twenty patients with torticollis had electromyographic studies of their neck muscles performed before and after a series of local injections of botulinum toxin. The pattern of muscle activity changed after the injections, and this effect persisted even after head position had returned to baseline. Patients who did not experience any clinical benefit from the injections also demonstrated a change in the pattern of muscle activity. These results suggest that the underlying abnormality in torticollis usually involves a general motor program for head position, rather than the activity of individual neck muscles.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/50342/1/410290407_ftp.pd

Molecular epigenetics, chromatin, and NeuroAIDS/HIV: Immunopathological implications

Epigenetics studies factors related to the organism and environment that modulate inheritance from generation to generation. Molecular epigenetics examines non-coding DNA (ncdDNA) vs. coding DNA (cdDNA), and pertains to every domain of physiology, including immune and brain function. Molecular cartography, including genomics, proteomics, and interactomics, seeks to recognize and to identify the multi-faceted and intricate array of interacting genes and gene products that characterize the function and specialization of each individual cell in the context of cell-cell interaction, tissue, and organ function. Molecular cartography, epigenetics, and chromatin assembly, repair and remodeling (CARR), which, together with the RNA interfering signaling complex (RISC), is responsible for much of the control and regulation of gene expression, intersect

Cerebellar control of movement

No Abstract.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/50354/1/410350103_ftp.pd

Dualistic geometry of the manifold of higher-order neurons

Abstract Recursive Fractal Genome Function in the geometric mind frame of Tensor Network Theory (TNT) leads through FractoGene to a mathematical unification of physiological and pathological development of neural structure and function as governed by the genome. The cerebellum serves as the best platform for unification of neuroscience and genomics. The matrix of massively parallel neural nets of fractal Purkinje brain cells explains the sensorimotor, multidimensional non-Euclidean coordination by the cerebellum acting as a space-time metric tensor. In TNT, the recursion of covariant sensory vectors into contravariant motor executions converges into Eigenstates composing the cerebellar metric as a Moore-Penrose Pseudo-Inverse. The Principle of Recursion is generalized to genomic systems with the realization that the assembly of proteins from nucleic acids as governed by regulation of coding RNA (cRNA) is a contravariant multi-component functor, where in turn the quantum states of resulting protein structures both in intergenic and intronic sequences are measured in a covariant manner by non-coding RNA (ncRNA) arising as a result of proteins binding with ncDNA modulated by transcription factors. Thus, cRNA and ncRNA vectors by their interference constitute a genomic metric. Recursion through massively parallel neural network and genomic systems raises the question if it obeys the Weyl law of Fractal Quantum Eigenstates, or when derailed, pathologically results in aberrant methylation or chromatin modulation; the root cause of cancerous growth. The growth of fractal Purkinje neurons of the cerebellum is governed by the aperiodical discrete quantum system of sequences of DNA bases, codons and motifs. The full genome is fractal; the discrete quantum system of pyknonlike elements follows the Zipf-Mandelbrot Parabolic Fractal Distribution curve. The Fractal Approach to Recursive Iteration has been used to identify fractal defects causing a cerebellar disease, the Friedreich Spinocerebellar Ataxia -in this case as runs disrupting a fractal regulatory sequence. Massive deployment starts by an open domain collaborative definition of a standard for fractal genome dimension in the embedding spaces of the genome-epigenome-methylome to optimally diagnose cancerous hologenome in the nucleotide, codon or motif-hyperspaces. Recursion is parallelized both by open domain algorithms, and also by proprietary FractoGene algorithms on high performance computing platforms, for genome analytics on accelerated private hybrid clouds with PDA personal interfaces, becoming the mainstay of clinical genomic measures prior and post cancer intervention in hospitals and serve consumers at large as Personal Genome Assistants. References 1

Modified Cross-Correlation for Efficient White-Beam Inelastic Neutron Scattering Spectroscopy

We describe a method of white-beam inelastic neutron scattering for improved measurement efficiency. The method consists of matrix inversion and selective extraction. The former is to resolve each incident energy component from the white-beam data, and the latter eliminates contamination by elastic components, which produce strong backgrounds that otherwise obfuscate the inelastic scattering components. In this method, the optimal experimental condition to obtain high efficiency will strongly depend on the specific aim of the individual experiments.Comment: 6 pages, 3 figure