Electronic and magnetic properties of Lu and LuH2_2

Clarifying the electronic and magnetic properties of lutetium, lutetium dihydride, and lutetium oxide is very helpful to understand the emergent phenomena in lutetium-based compounds (such as room-temperature superconductivity). However, this kind of study is still scarce at present. Here, we report on the electronic and magnetic properties of lutetium metals, lutetium dihydride powders, and lutetium oxide powders. Crystal structures and chemical compositions of these samples were characterized by X-ray diffraction and X-ray photoemission spectroscopy, respectively. Electrical transport measurements show that the resistance of lutetium has a linear behavior depending on temperature, whereas the resistance of lutetium dihydride powders is independent of temperature. More interestingly, paramagnetism-ferromagnetism-spin glass transitions were observed at near 240 and 200 K, respectively, in lutetium metals. Our work uncovered the complex magnetic properties of Lu-based compounds

trans-Trismethoxy Resveratrol Decreased Fat Accumulation Dependent on Fat-6 and Fat-7 in Caenorhabditis Elegans

trans-Trismethoxy resveratrol (TMR) is a methyl analog of resveratrol. It is found to exhibit enhanced biological effects compared to resveratrol, such as inhibition of cancer cell growth and pro-apoptotic activities. However, the role of TMR in lipid metabolism is not fully understood. In this study, we used Caenorhabditis elegans, an in vivo nematode model which has been widely applied in disease research, including research on obesity, to investigate the effect of TMR on lipid metabolism. Treatment with TMR (100 and 200 μM) for 4 days significantly reduced triglyceride accumulation (14% and 20% reduction over the control, respectively) of C. elegans, without affecting nematode growth, food intake and reproduction. Treatment with TMR significantly downregulated stearoyl-CoA desaturase genes, fat-6 and fat-7, accompanied by a decrease in the desaturation index of fatty acids, the ratio of oleic acid to stearic acid. These results suggest that TMR inhibits fat accumulation by downregulating stearoyl-CoA desaturase in C. elegans

Transformation of hexagonal Lu to cubic LuH2+x_{2+x} single-crystalline films

With the recent report of near ambient superconductivity at room temperature in the N-doped lutetium hydride (Lu-H-N) system, the understanding of cubic Lu-H compounds has attracted worldwide attention. Generally, compared to polycrystal structures with non-negligible impurities, the single-crystalline form of materials with high purity can provide an opportunity to show their hidden properties. However, the experimental synthesis of single-crystalline cubic Lu-H compounds has not been reported thus far. Here, we developed an easy way to synthesize highly pure LuH$_{2+x}$ single-crystalline films by the post-annealing of Lu single-crystalline films (purity of 99.99%) in the H$_2$ atmosphere. The crystal and electronic structures of films were characterized by X-ray diffraction, Raman spectroscopy, and electrical transport. Interestingly, Lu films are silver-white and metallic, whereas their transformed LuH$_{2+x}$ films become purple-red and insulating, indicating the formation of an unreported electronic state of Lu-H compounds possibly. Our work provides a novel route to synthesize and explore more single-crystalline Lu-H compounds

Large Language Models are not Fair Evaluators

We uncover a systematic bias in the evaluation paradigm of adopting large language models~(LLMs), e.g., GPT-4, as a referee to score the quality of responses generated by candidate models. We find that the quality ranking of candidate responses can be easily hacked by simply altering their order of appearance in the context. This manipulation allows us to skew the evaluation result, making one model appear considerably superior to the other, e.g., vicuna could beat ChatGPT on 66 over 80 tested queries. To address this issue, we propose two simple yet effective calibration strategies: 1) Multiple Evidence Calibration, which requires the evaluator model to generate multiple detailed pieces of evidence before assigning ratings; 2) Balanced Position Calibration, which aggregates results across various orders to determine the final score. Extensive experiments demonstrate that our approach successfully mitigates evaluation bias, resulting in closer alignment with human judgments. To facilitate future research on more robust large language model comparison, we integrate the techniques in the paper into an easy-to-use toolkit \emph{FairEval}, along with the human annotations.\footnote{\url{https://github.com/i-Eval/FairEval}}Comment: work in progres

Risk Factors For Recurrent Stroke After Coronary Artery Bypass Grafting

<p>Abstract</p> <p>Objectives</p> <p>Preventing stroke after coronary artery bypass grafting (CABG) remains a therapeutic goal, due in part to the lack of identifiable risk factors. The aim of this study, accordingly, was to identify risk factors in CABG patients with a previous history of stroke.</p> <p>Methods</p> <p>Patients with a history of stroke who underwent CABG at Beijing An Zhen hospital from January 2007 to July 2010 were selected (n = 430), and divided into two groups according to the occurrence of postoperative stroke. Pre-operative and post-operative data were retrospectively collected and analyzed by univariate and multivariate logistic regression analyses.</p> <p>Results</p> <p>Thirty-two patients (7.4%) suffered post-operative stroke. Univariate analysis identified several statistically significant risk factors in the post-operative stroke group, including pre-surgical left ventricular ejection fractions (LVEF) ≤50%, on-pump surgery, post-operative atrial fibrillation (AF), and hypotension. Multivariable analysis identified 4 independent risk factors for recurrent stroke: unstable angina (odds ratio (OR) = 2.95, 95% CI: 1.05-8.28), LVEF ≤50% (OR = 2.77, 95% CI: 1.23-6.27), AF (OR = 4.69, 95% CI: 1.89-11.63), and hypotension (OR = 2.55, 95% CI: 1.07-6.04).</p> <p>Conclusion</p> <p>Unstable angina, LVEF ≤50%, post-operative AF, and post-operative hypotension are independent risk factors of recurrent stroke in CABG patients with a previous history of stroke.</p

Sex-based differences in outcomes after severe injury: an analysis of blunt trauma patients in China

Abstract Background Experimental research suggests that females have a higher survival rate after trauma, although this claim is controversial. This study sought to determine the role of sex on mortality among trauma patients in China. Methods The study enrolled 1789 trauma patients who visited the Emergency Intensive Care Unit of the First Affiliated Hospital of Zhengzhou University during 2015 and 2016. A retrospective data analysis was performed to determine sex-based differences after blunt trauma. Patients were stratified by age and injury severity (using the Injury Severity Score). Multiple logistic regression was used to analyze the association between sex and post-injury complications and mortality. Results Female trauma patients experienced a significantly lower risk of mortality than males (odds ratio, 0.931; 95% confidence interval, 0.883–0.982). This survival advantage of females was particularly notable in the ‘younger than 45 years’ age group. Sex-based differences were also found in the occurrence of life-threatening complications after trauma. Conclusion This study demonstrated that females are more likely to survival after severe blunt trauma and also have less inpatient complications than men, suggesting an important role for sex hormones after severe traumatic injury

Ridge and furrow systems with film cover increase maize yields and mitigate climate risks of cold and drought stress in continental climates

Ridge-furrow tillage and plastic film cover are widely applied in China to mitigate climate risks, e.g. cool temperature and low rainfall. This study aimed to quantify the effects of ridge-furrow tillage and film cover on maize growth and yield in an environment with frequent seasonal drought and cold spells. Field experiments were carried out in 2013 and 2014 in Jilin and Inner Mongolia, northeast China. Maize yield without film cover increased 15% by ridging, and further increases of 9% or 16% were achieved by applying 58% or 100% film cover, respectively. Maize growth rate was significantly enhanced by both partial and full film cover, but not significantly increased by ridging alone. The time reached to the maximum growth rate was significantly advanced. The growing duration of maize was significantly shortened by film cover while ridging did not affect. The increase of maize yield by ridge and film cover was associated with significant increases in kernel number per ear, kernel weight and harvest index. Harvest index of maize increased with 11% by ridge-furrow tillage and with a further 15–17% by film cover. We conclude that maize with ridge and film cover increases crop yield by enhancing crop growth and development and could also reduce risks of crop failure due to drought or cold spells. The results could help optimize maize management in arid continental regions where yields are constrained by drought and a short growing season due to low temperature

Dosing interval regimen shapes potency and breadth of antibody repertoire after vaccination of SARS-CoV-2 RBD protein subunit vaccine

Vaccination with different vaccines has been implemented globally to counter the continuous COVID-19 pandemic. However, the vaccine-elicited antibodies have reduced efficiency against the highly mutated Omicron sub-variants. Previously, we developed a protein subunit COVID-19 vaccine called ZF2001, based on the dimeric receptor-binding domain (RBD). This vaccine has been administered using different dosing intervals in real-world setting. Some individuals received three doses of ZF2001, with a one-month interval between each dose, due to urgent clinical requirements. Others had an extended dosing interval of up to five months between the second and third dose, a standard vaccination regimen for the protein subunit vaccine against hepatitis B. In this study, we profile B cell responses in individuals who received three doses of ZF2001, and compared those with long or short dosing intervals. We observed that the long-interval group exhibited higher and broader serologic antibody responses. These responses were associated with the increased size and evolution of vaccine-elicited B-cell receptor repertoires, characterized by the elevation of expanded clonotypes and somatic hypermutations. Both groups of individuals generated substantial amounts of broadly neutralizing antibodies (bnAbs) against various SARS-CoV-2 variants, including Omicron sub-variants such as XBB. These bnAbs target four antigenic sites within the RBD. To determine the vulnerable site of SARS-CoV-2, we employed cryo-electron microscopy to identify the epitopes of highly potent bnAbs that targeted two major sites. Our findings provide immunological insights into the B cell responses elicited by RBDbased vaccine, and suggest that a vaccination regimen of prolonging time interval should be used in practice