Resveratrol treatment increases FoxO1a, FoxO3a and FoxO4 expression in RD retina.

<p>There is baseline expression of FoxO1a, FoxO3a and FoxO4 in attached retina without Resveratrol treatment, Resveratrol treatment doesn’t change FoxO family protein expression (Con Resveratrol). RD alone also does not increase FoxO family protein expression. Summary data show a statistically significant increase of all three FoxO transcription factors protein level in Resveratrol treatment RD retina (RD Resveratrol).</p

Effect of cellular senescence on the P2Y-receptor mediated calcium response in trabecular meshwork cells-1

<p><b>Copyright information:</b></p><p>Taken from "Effect of cellular senescence on the P2Y-receptor mediated calcium response in trabecular meshwork cells"</p><p></p><p>Molecular Vision 2007;13():1926-1933.</p><p>Published online 16 Oct 2007</p><p>PMCID:PMC2185512.</p><p></p

Effect of Resveratrol on levels of Caspase 3, 8 and 9 in RD.

<div><p>(A) Western blots showing three days after RD, increased expression of caspase 3, cleaved caspase 3, caspase 8 and caspase 9 in detached retina. Resveratrol treatment decreases cleaved caspase 3, caspase 8 and caspase 9 production. (B) Summary data show a statistically significant deduction of cleaved caspase 3, caspase 8 and caspase 9 in detached part of retina treated Resveratrol (RD Resveratrol) when comparing with detached retina treated with Vehicle (RD Vehicle) (mean ± SEM).</p> <p>★: P < 0.05 statistically significant compare to RD vehicle.</p></div

Effect of cellular senescence on the P2Y-receptor mediated calcium response in trabecular meshwork cells-2

<p><b>Copyright information:</b></p><p>Taken from "Effect of cellular senescence on the P2Y-receptor mediated calcium response in trabecular meshwork cells"</p><p></p><p>Molecular Vision 2007;13():1926-1933.</p><p>Published online 16 Oct 2007</p><p>PMCID:PMC2185512.</p><p></p

The protective effect of Resveratrol on ONL.

<p>Quantitative data exhibiting the protective effect of Resveratrol on ONL thickness preservation 3 days after RD. Resveratrol treatment group has 59% less of ONL thickness loss (p<0.05, n=6).</p

Spectrin cleavage in detached retina.

<div><p>(A) Western blots showing three days after RD, increased expression of 145 and 120-kDa bands in detached retina. Resveratrol treatment only decreases the production of 120-kDa bands. (B) Summary data show a statistically significant increase in the 120-kDa spectrin cleavage product in detached part of retina treated vehicle (RD vehicle) when comparing with attached part of retina (AR) of same eye. Resveratrol treatment significantly decreases 120-kDa spectrin cleavage product (mean ± SEM) in detached retina (RD Resveratrol). (C) Summary data show a statistically significant increase in the 145-kDa spectrin cleavage product in RD vehicle and RD Resveratrol. Resveratrol treatment dose not significantly decrease 145-kDa spectrin cleavage product (mean ± SEM).</p> <p>★: P < 0.05 statistically significant compare to AR.</p> <p>✖: P < 0.05 statistically significant compare to RD vehicle.</p></div

Systemic Resveratrol administration decreases photoreceptor cell loss in RD.

<p>(A) DAPI (blue) and TUNEL (green) staining of detached retina sections. (B) Quantitative analysis of TUNEL positive cells 3 days after RD with or without daily treatment (20mg/kg/day, I.P.). Resveratrol treatment significantly decreases TUNEL positive cells (p<0.05, n=6).</p

Effect of cellular senescence on the P2Y-receptor mediated calcium response in trabecular meshwork cells-0

<p><b>Copyright information:</b></p><p>Taken from "Effect of cellular senescence on the P2Y-receptor mediated calcium response in trabecular meshwork cells"</p><p></p><p>Molecular Vision 2007;13():1926-1933.</p><p>Published online 16 Oct 2007</p><p>PMCID:PMC2185512.</p><p></p

Effect of cellular senescence on the P2Y-receptor mediated calcium response in trabecular meshwork cells-3

<p><b>Copyright information:</b></p><p>Taken from "Effect of cellular senescence on the P2Y-receptor mediated calcium response in trabecular meshwork cells"</p><p></p><p>Molecular Vision 2007;13():1926-1933.</p><p>Published online 16 Oct 2007</p><p>PMCID:PMC2185512.</p><p></p

Effects of stable expression of the β5 proteasome subunit on the accumulation of carbonylated proteins after HO treatment in LECs

Basal level of carbonyl content measured prior to treatment with HO showed no significant difference between LECs expressing β5 subunit and controls (0.41±0.10 nmol/mg and 0.45±0.12 nmol/mg, respectively, p>0.05). When LECs were exposed to 40 mM HO, carbonyl content increased both in LECs overexpressing β5 and control cells. The accumulation of carbonyl proteins was significantly lower in LECs expressing β5 (1.63±0.36 nmol/mg versus 2.65±0.44 nmol/mg, p<p><b>Copyright information:</b></p><p>Taken from "Cytoprotective effects of proteasome β5 subunit overexpression in lens epithelial cells"</p><p></p><p>Molecular Vision 2007;13():31-38.</p><p>Published online 16 Jan 2007</p><p>PMCID:PMC2503187.</p><p></p