Effects of stable expression of the β5 proteasome subunit on the accumulation of carbonylated proteins after HO treatment in LECs

Abstract

Basal level of carbonyl content measured prior to treatment with HO showed no significant difference between LECs expressing β5 subunit and controls (0.41±0.10 nmol/mg and 0.45±0.12 nmol/mg, respectively, p>0.05). When LECs were exposed to 40 mM HO, carbonyl content increased both in LECs overexpressing β5 and control cells. The accumulation of carbonyl proteins was significantly lower in LECs expressing β5 (1.63±0.36 nmol/mg versus 2.65±0.44 nmol/mg, p<p><b>Copyright information:</b></p><p>Taken from "Cytoprotective effects of proteasome β5 subunit overexpression in lens epithelial cells"</p><p></p><p>Molecular Vision 2007;13():31-38.</p><p>Published online 16 Jan 2007</p><p>PMCID:PMC2503187.</p><p></p

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