39 research outputs found
Contribuição ao desenvolvimento de métodos não-invasivos de investigação da musculatura respiratória
BV UNIFESP: Teses e dissertaçõe
Alterações cognitivas na SAOS Cognitive impairment in obstructive sleep apnea syndrome
Alterações da cognição e do desempenho estão bem estabelecidas em pacientes com SAOS, causando um impacto significativo sobre a qualidade de vida e o risco de acidentes nesses indivíduos. Tais alterações são mais profundas nos quadros mais graves de SAOS, o que explica a aparente discrepância na frequência e gravidade desse prejuízo entre estudos com pacientes de clínicas de sono e estudos de base populacional. Vários aspectos podem estar comprometidos, incluindo o processamento cognitivo, a atenção sustentada, as funções executivas e a memória. Entretanto, os mecanismos causais desses déficits não estão inteiramente elucidados, e existem controvérsias, particularmente em relação à contribuição relativa da hipóxia intermitente e da interrupção do sono presentes na SAOS. O impacto da sonolência diurna sobre o desempenho desses pacientes nos diversos testes cognitivos também ainda deve ser determinado, assim como o possível efeito de comorbidades frequentes, incluindo o diabete melito, a hipertensão arterial sistêmica, a doença cardiovascular e a obesidade. Existem evidências convincentes de que o tratamento com CPAP produz uma significativa melhora do desempenho e da cognição, sobretudo nos portadores de SAOS moderada e grave, embora sejam necessários mais estudos acerca do seu impacto a longo prazo.<br>Cognitive and performance impairment is well established in patients with obstructive sleep apnea syndrome (OSAS), having a significant impact on the quality of life and the risk of accidents in these individuals. The severity of the impairment correlates with that of the OSAS, which explains the apparent discrepancy between studies using patients from sleep clinics and population-based studies in terms of the reported frequency and severity of such impairment. Cognitive processing, sustained attention, executive functioning, and memory have all been reported to be impaired in OSAS. However, the causal mechanisms of these deficits have not been entirely clarified, and the relative contribution of intermittent hypoxia and sleep disruption in OSAS is particularly controversial. The potential effect of daytime sleepiness on the performance of these patients on various cognitive tests has yet to be determined, as does that of common comorbidities, such as diabetes, systemic arterial hypertension, cardiovascular disease, and obesity. There is compelling evidence that CPAP treatment can improve performance and cognition, particularly in mild to moderate cases, although further studies on the long-term impact of this type of treatment are still needed
Adaptation of the night eating questionnaire for Brazilian adolescents
Introduction Night Eating Syndrome (NES) is characterized by a delay in the circadian rhythm
of food intake and affects 1.5% of the general population, occurring more frequently in obese
people. The Night Eating Questionnaire (NEQ) was originally developed for the American adult
population. It is a self-administered instrument widely used in the identification and follow-up
of individuals with NES. Although the NEQ has been translated and validated for Brazilian
adults, there are no reports of its adaptation for use in Brazilian adolescents. The present study
aimed to adapt and evaluate reliability and reproducibility of the NEQ for Brazilian adolescents.
Material and Methods Initially, a semantic adaptation of the Portuguese version of the NEQ
was performed by 3 professionals with experience with adolescents. The suggested text was
analyzed and consolidated item by item by the researchers and then presented to 21 adolescents
from an intermediate school in Fortaleza. The questions with low level of understanding (<90%)
were modified and the questionnaire was re-applied to 23 adolescents, obtaining satisfactory
understanding. Results The version of the NEQ for Brazilian adolescents, compared to the adult
version, contains changes in items 3, 5, 6, 7 and 13. The questionnaire was administered to 463
students aged 11 to 17 years (mean ± SD = 13.7 ± 1.2), from 3 schools. The internal consistency,
measured by the Cronbach’s alpha coefficient, was 0.73. The reproducibility that was measured
after one week in 27 adolescents was 0.92 (95% CI 0.82-0.96). Conclusion The new version of the
NEQ for Brazilian adolescents presents excellent reproducibility and good internal consistency and
is a simple and useful instrument to evaluate nocturnal eating symptoms in this age group