Comments on “Efficacy and safety assessment of acupuncture and nimodipine to treat mild cognitive impairment after cerebral infarction: a randomized controlled trial"

Carta el editor de BMC Complementary and Alternative Medicine, en la que los autores muestran los resultados de aplicar apucuntura y nimodipina en el tratamiento del deterioro cognitivo leve en personas que han sufrido un infarto cerebral.Letter from the editor of BMC Complementary and Alternative Medicine, in which the authors show the results of applying apuncture and nimodipine in the treatment of mild cognitive impairment in people who have suffered a cerebral infarction.peerReviewe

Comment on "Assessment of bone mineral density in male patients with chronic obstructive pulmonary disease by DXA and quantitative computed tomography"

Valoración de los datos de la tabla 2, del trabajo "Assessment of bone mineral density in male patients with chronic obstructive pulmonary disease by DXA and quantitative computed tomography", publicado en 2016. Esta precisión se hace por los profesores del Departamento de Enfermería, de la Universidad de ExtremaduraAssessment of the data in Table 2, from the work "Assessment of bone mineral density in male patients with chronic obstructive pulmonary disease by DXA and quantitative computed tomography", published in 2016. This precision is done by the professors of the Department of Nursing, the University of ExtremadurapeerReviewe

Methods for nurses to measure body composition

Among the methods available for assessing body composition, traditional methods like hydrodensitometry and skin-fold measurements are well known. In this review, we focus on the impedance and interactance methods, which use systems that are usually inexpensive, easily transportable and simple to operate. We also discuss the usefulness of dual energy X-ray absorptiometry, particularly for the measurement of fat distribution. Nurses need to be skilled in the use of the equipment and familiar with the techniques.Entre los métodos disponibles para la determinación de la composición corporal, los tradicionales como la hidrodensitometría y la valoración de pliegues corporales son bien conocidos. En esta revisión nos centramos en los métodos basados en la impedancia y en la interactancia, caracterizados por la utilización de equipos económicos, fáciles de transportar y manejar. También discutimos la utilidad de la absorciometría dual de rayos-X, particularmente para la determinación de la distribución de la grasa corporal. Es importante que el personal de enfermería adquiera competencias en el uso de estos equipamientos y también se familiarice con las técnicas descritas.Entre os métodos disponíveis para a determinação da composição corporal, os tradicionais, como a hidrodensitometria e a avaliação de pregas corporais, são bem conhecidos. Para esta revisão, centrou-se nos métodos baseados na impedância e a interactância, caracterizados pela utilização de equipamentos econômicos, fáceis de transportar e manobrar. Também discutiu-se a utilidade da absorciometria dual de raios X, especialmente para a determinação da distribuição da gordura corporal. É importante que o pessoal de enfermagem adquira conhecimentos sobre o uso desse equipamento, bem como que se familiarize com as técnicas descritas

Common allelic variants of the vitamin receptor D gene rs7975232 (Apai) do not influence bone mineral density figures in postmenopausal osteoporotic women

Este estudio examina la asociación entre la densidad mineral ósea (DMO) y el polimosfirmo rs7975232 (ApaI) del gen receptor de la vitamina D (VDR). El polimorfismo es detectado mediante un PCR en tiempo real por el método TaqMan. El genotipo rs7975232, se determinó en 274 fracturas osteoporóticas en mujeres españolas posmenopáusicas, con 60.53±8.02 años. Las frecuencias genotípicas observadas estaban de acuerdo con el equilibrio de Hardy-Weinberg (χ2=1.85, p=0.1736). No hubo diferencias significativas en el grupo genotipo rs7975232 de la muestra total de fracturas osteoporóticas por mujeres en edad, años después de la menopausia, la altura, el peso y la DMO en el cuello femoral, trochanter femoral y columna lumbar. Se encontraron diferencias significativas en la edad de la menarca (aa vs Aa; P=0,008) y el IMC (aa vs AA; P=0.029). Concluimos que el gen VDR del polimorfismo rs7975232 no está relacionado con las cifras de la densidad mineral ósea en fracturas osteoporóticas en mujeres españolas.This study examined the association between bone mineral density (BMD) and the rs7975232 (ApaI) poly¬morphism of the vitamin receptor D (VDR) gene. The polymorphism was detected using the real-time PCR TaqMan method. The rs7975232 genotype was determined in 274 postmenopausal osteoporotic Spanish women who were 60.53±8.02 years old. The observed genotype frequencies were in agreement with Hardy-Weinberg equilibrium (χ2=1.85, P=0.1736). There were no significant differences in the rs7975232 genotype groups in our total sample of osteoporotic women regarding age, years since menopause, height, weight, and BMD at femoral neck, femoral trochanter and lumbar spine. Significant differences were found in menarche age (aa vs Aa; P=0.008) and BMI (aa vs AA; P=0.029). We conclude that the VDR gene rs7975232 polymorphism is not related to figures of bone mineral density in postmenopausal osteoporotic Spanish women.peerReviewe

Lack of influence of vitamin D receptor bsmI (rs1544410) polymorphism on the rate of bone loss in a cohort of postmenopausal Spanish women affected by osteoporosis and followed for five years

Se ha realizado un estudio longitudinal para investigar la relación entre un polimorfismo en el gen receptor de la vitamina D (VDR) y los cambios en la densidad mineral ósea (DMO) y ultrasonido cuantitativo de las falanges (QUS) durante un período de cinco años. Los sujetos fueron 456 mujeres posmenopáusicas con osteoporosis en tratamiento, de edades comprendidas entre los 59,95±7,97 años (media ± desviación estándar [SD]) en la línea de base. Se midió la DMO en columna lumbar y la cadera mediante absorciometría de rayos X de doble energía y el QUS fue medido por medio de una velocidad que depende de la amplitud del sonido Ad SoS en las falanges. La información de estilo de vida se obtiene a través de un cuestionario. Las frecuencias de los genotipos BsmI (rs1544410) polimorfismo genético fueron 29,4%, 47,1% y 23,5%para bb, BB y BB, respectivamente. Después de cinco años, la DMO (variación anual en %/año) en el cuello femoral (FN) mostraron una modificación significativa sobre la base de la rs1544410 genotipo (BB vs Bb); hubo una disminución general de la masa ósea (0,70±2,79%/año; P = 0,025). Un análisis de covarianza con ajustes para la edad, peso, altura, porcentaje de cambio de peso por año, previsto la DMO y la ingesta de calcio mostraron que las asociaciones observadas ya no fueron significativas (P = 0,429). No se hallaron asociaciones significativas entre las mediciones QUS y el genotipo rs1544410 después del período de cinco años. Las limitaciones de nuestro estudio incluyen la falta de información sobre el tipo y la duración de la duración del tratamiento de la osteoporosis. Nuestros resultados indican que los polimorfismos rs1544410 no cuentan significativamente por los cambios en la masa ósea en mujeres españolas con osteoporosis en tratamiento.A longitudinal study was conducted to investigate the relation between a polymorphism in the vitamin D receptor (VDR) gene and changes in bone mineral density (BMD) and quantitative ultrasound of the phalanges (QUS) over a five-year period. The subjects were 456 postmenopausal women with steoporosis undergoing treatment, aged 59.95±7.97 years (mean ± standard deviation [SD]) at baseline. BMD was measured at the hips and lumbar spine by dual energy X-ray absorptiometry, and QUS was measured by means of amplitude-dependent speed of sound (Ad SoS) at the phalanges. Lifestyle information was obtained via a questionnaire. The genotype frequencies of the BsmI (rs1544410) gene polymorphism were 29.4%, 47.1%, and 23.5%for bb, Bb, and BB, respectively. After five years, BMD (annual change in %/year) at the femoral neck (FN) showed a significant modification based on the rs1544410 genotype (BB vs Bb); there was an overall decrease in bone mass (-0.70±2.79%/year; P = 0.025). An analysis of covariance with adjustments for age, weight, height, percentage of weight change per year, baseline BMD and calcium intake showed that the observed associations were no longer significant (P = 0.429). No significant associations were found between the QUS measurements and the rs1544410 genotype after the five-year period. Our study limitations includes lack of information about type and length of duration of the osteoporosis treatment. Our results indicate that rs1544410 polymorphisms do not account ignificantly for the changes in bone mass in Spanish women with osteoporosis undergoing treatment.peerReviewe

Cytotoxic effects of curcumin in osteosarcoma cells

Carta al editor de International Journal of Nanomedicine, en la que los autores puntualizan ciertos resultados de investigaciones de R. Chang et al.; y de D. K. Walters et al. en relación a sus aplicaciones para la curación de algunos cánceres y enfermedades óseas metabólicas.Letter to the editor of International Journal of Nanomedicine, in which the authors point out certain results of research by R. Chang et al.; and DK Walters et al. in relation to their applications for the cure of some cancers and metabolic bone diseases

Lack of association of vitamin D receptor BsmI gene polymorphism with bone mineral density in Spanish postmenopausal women

La osteoporosis es un trastorno poligénico que está determinada por los efectos de varios genes, cada uno con efectos relativamente modestos en la masa ósea. El objetivo de este estudio es determinar si el receptor de la vitamina D, único nucleótido polimorfismo BsmI, está asociado con la densidad mineral ósea (DMO) de mujeres posmenopáusicas españolas. Un total de 210 mujeres posmenopáusicas sanas, mayores de 60 ± 8 años, fueron genotipificadas utilizando ensayos de genotipado SNP TaqMan® lumbar y la DMO femoral; y se determinó por la absorciometría de rayos X de energía dual (DEXA) la cantidad diaria de calcio y vitamina D. No se encontraron diferencias en el cuello femoral, trocánter, triángulo de salas, L2, L3, L4, L2-L4, o entre el cuello femoral y la DMO de cadera total tras el ajuste para posibles factores de confusión (P > 0,05) (edad, IMC, años después de la menopausia y la ingesta diaria de calcio). La BsmI polimorfismo en el gen VDR no se asoció con la DMO en mujeres posmenopáusicas españolas.Osteoporosis is a polygenic disorder that is determined by the effects of several genes, each with relatively modest effects on bone mass. The aim of this study was to determine whether the vitamin D receptor single nucleotide polymorphism BsmI is associated with bone mineral density (BMD) in Spanish postmenopausal women. A total of 210 unrelated healthy postmenopausal women aged 60 ± 8 years were genotyped using TaqManR SNP Genotyping Assays. Lumbar and femoral BMD were determined by dual-energy X-ray absorptiometry (DEXA). Daily calcium and vitamin D intake were determined by a food questionnaire. No differences were found in the femoral neck, trochanter, Ward’s Triangle, L2, L3, L4, L2-L4, or between the femoral neck and total hip BMD after further adjustment for potential confounding factors (P > 0.05) (age, BMI, years since menopause and daily calcium intake). The BsmI polymorphism in the VDR gene was not associated with BMD in Spanish postmenopausal women.peerReviewe

Longitudinal Analysis of Plantar Pressures with Wear of a Running Shoe

Running shoes typically have a lifespan of 300–1000 km, and the plantar pressure pattern during running may change as the shoe wears. So, the aim of this study was to determine the variation of plantar pressures with shoe wear, and the runner’s subjective sensation. Maximun Plantar Pressures (MMP) were measured from 33 male recreational runners at three times during a training season (beginning, 350 km, and 700 km) using the Biofoot/IBV® in-shoe system (Biofoot/IBV®, Valencia, Spain). All the runners wore the same shoes (New Balance® 738, Boston, MA, USA) during this period, and performed similar training. The zones supporting most pressure at all three study times were the medial (inner) column of the foot and the forefoot. There was a significant increase in pressure on the midfoot over the course of the training season (from 387.8 to 590 kPa, p = 0.003). The runners who felt the worst cushioning under the midfoot were those who had the highest peak pressures in that area (p = 0.002). The New Balance® 738 running shoe effectively maintains the plantar pressure pattern after 700 km of use under all the zones studied except the midfoot, probably due to material fatigue or deficits of the specific cushioning systems in that area.Junta de Extremadura y Fondo Europeo de Desarrollo Regional (FEDER) GR15073 y GR1817

Plantar pressures values related with appearance of mechanical hyperkeratosis before and after surgery of mild hallux valgus

BackgroundHyperkeratoses are thickenings of the stratum corneum, provoked by deviation of the ray and excessive plantar pressures. They are very common under the first metatarsal head (MTH) and on the big toe when there exists hallux valgus. The objective of this study was to assess plantar pressures pre- and post-surgery to try to define the threshold values that could determine the appearance of keratopathies.Materials and methodsSeventy-nine patients (100 feet) who had undergone percutaneous distal soft-tissue release and the Akin procedure were evaluated prospectively. The BioFoot/IBV® in-shoe system was used for objective baropodometric functional evaluations of the heel, midfoot, first through fifth MTHs, hallux, and lesser toes. The presence or absence of a hyperkeratosis (HK) or plantar callus under the first MTH or hallux was recorded. The average follow-up time at which the measurements were repeated was 28.1 months.ResultsPre-surgery, 62 feet presented a painful HK on the big toe, while post-surgery, only 9 of the feet presented the same lesion. Patients who presented a prior HK at the first metatarsophalangeal (MTP) joint had a mean pressure of 417.2 ± 254.5 kPa as against a value of 359.6 ± 185.1 kPa for the rest. Post-surgery, these values dropped to 409.8 and 346.3 kPa, respectively.ConclusionPatients with HK presented an 11% greater mean pressure than those without. The values obtained with the BioFoot/IBV® system in the present study can therefore be considered predictive of the appearance of HK under the first MTH and on the side of the big toe