Synthesis and Biological Evaluation of Some Novel Substituted N-Benzylideneaniline Derivatives

ABSTRACT N-benzylideneaniline is a class of important compounds in medicinal and pharmaceutical field. Nbenzylideneaniline represents a model aromatic Schiff base and it is also a classic bioisoster of stilbene and resveratrol. Keeping in view the biological importance of N-benzylideneaniline we have synthesized some novel Nbenzylideneaniline derivatives. The prepared compounds were tested for their in vitro antibacterial, antifungal and antioxidant activity. (4-fluoro-benzylidene)-(3,5-dichloro-phenyl)-amine (5i) showed in vitro antibacterial activity comparable to that of the standard Penicillin against Escherichia coli. The results of the in vitro antifungal activity showed that most of the synthesized derivatives have proven their antifungal potential. The results of the in vitro antioxidant tests showed that most of the synthesized compounds showed moderate (%RSA >50%) to mild (%RSA >40%) radical scavenging activity

Integrated multisectoral strategy to improve girls' and women's nutrition before conception, during pregnancy and after birth in India (Swabhimaan): protocol for a prospective, non-randomised controlled evaluation

INTRODUCTION: Swabhimaan is a community-based programme to improve adolescent girls’ and women’s nutrition in the rural areas of three Indian states—Bihar, Chhattisgarh and Odisha with high prevalence of undernutrition. METHODS AND ANALYSIS: Swabhimaan has a nested prospective, non-randomised controlled evaluation. Since 2017, five intervention sites receive community-led interventions through national government’s livelihood mission supported women’s self-help group federations and five control sites will initiate these activities 36 months later, in 2020. Community-led activities aim to improve coverage of 18 interventions including adequacy of food consumed, prevention of micronutrient deficiencies, access to basic health services and special care of nutritionally ‘at risk’ girls and women, improving hygiene and access to water and sanitation services and access to family planning services. The evaluation includes baseline (2016–2017), midline (2018–2019) and endline (2020–2021) surveys covering 6638 adolescent girls, 2992 pregnant women and 8755 mothers of children under 2. The final impact analysis will be by intention to treat, comparing primary and secondary outcomes in five intervention areas and five control areas. The primary outcomes are: (1) a 15% reduction in the proportion of adolescent girls with a body mass index (BMI) <18.5 kg/m2; (2) a 15% reduction in the proportion of mothers of children under two with a BMI <18.5 kg/m2 and (3) and a 0.4 cm improvement in mean mid-upper arm circumference among pregnant women. ETHICS AND DISSEMINATION: All procedures involving human subjects were approved by the Institutional Ethics Committee of the All India Institute of Medical Sciences, Bihar, Chhattisgarh and Odisha and in compliance with guidelines laid down in the Declaration of Helsinki. Evidence will inform maternal and preconception nutrition policy at national and state level. TRIAL REGISTRATION NUMBER: 58261b2f46876 and CTRI/2016/11/007482; Pre-results

How is India doing on malnutrition and non-communicable diseases? Insights from the National Family Health Surveys (2005-06 to 2019-21)

A set of global nutrition targets for maternal and child nutrition together with diet related non communicable diseases ( to be achieved by 2025 was endorsed by the World Health Assembly in 2013 These targets provide goals against which progress towards ending malnutrition in all its forms can be measured and contribute to the Sustainable Development Goals This data note describes trends in multiple forms of malnutrition and NCD outcomes at the national, state, and district levels for India using survey data from NFHS 3 2005 06 NFHS 4 2015 2016 and NFHS 5 2019 2021 Insights on other malnutrition targets such as anemia and breastfeeding will be forthcomin

Coverage of nutrition and health interventions in India: Insights from the National Family Health Surveys

Nutrition-specific interventions are aimed at improving the food, health, and care environment for women and children during the first 1000 days. These interventions span pregnancy, postnatal, and early childhood periods and include food and micronutrient supplementation, nutrition education and/or counselling, growth monitoring and promotion, as well as routine immunization, deworming, and care during illness. At 90% coverage, these interventions can contribute to 20% reduction in stunting and 61% reduction in severe wasting. India’s policy framework for health and nutrition is robust and includes most evidence-based nutrition and health interventions. Two large-scale national program platforms – the Integrated Child Development Services and the National Health Mission – together deliver these interventions across the country. India’s efforts at scaling up nutrition interventions are now also bolstered by the National Nutrition Mission. This Data Note describes the coverage of key nutrition and health interventions for which data are available in the National Family Health Surveys for 2015-2016 and 2019-2021. To examine coverage of interventions, indicators were created based on global definitions and making adaptations to Indian policy context where necessary. Data on women of reproductive age (15-49 years) with a child below five years of age from the most recent birth was used to compute these indicators. Indicator definitions are provided in Annex 1 of this Note

Tracking anemia and its determinants from 2015-16 to 2019-21 in India

This Data Note provides an update on the prevalence of anemia and its determinants in India at state and districts levels, as well as coverage of a nutrition specific and nutrition sensitive interventions. Data were from the National Family Health Surveys in 2005 06, 2015 2016 and 2019 21. We first report national trends for 8 population groups (Figure 1 below). For each population group, we show anemia prevalence by severity category and at state and district levels using the two latest rounds of data. Lastly, we show recent trends in determinants of anemia and, nutrition and health interventions

Trends and patterns in consumption of foods among Indian adults: Insights from National Family Health Surveys, 2005-06 to 2019- 21

See also: https://poshan.ifpri.info/category/publications/data-notes/BACKGROUND| Healthy diets are necessary for optimal growth and to carry out daily mental and physical tasks. Unhealthy diets drive all forms of malnutrition and dietary risks are the number one risk factor globally for deaths and disability (Global Burden of Disease collaborators, 2019). Given the importance of diet as a key driver of health and wellbeing, this Data Note examines available data from three rounds of India’s National Family Health Surveys (NFHS) on food consumption patterns of adult men and women. MEASUREMENT| NFHS asks women (15-49 years) and men (15-54 years) how frequently (daily, weekly, occasionally or never) they consume nine food groups including two unhealthy food groups (Figure 1). The 2020 Nutrient Requirements for Indians outlines the quantity per day of vegetarian foods to be consumed as part of a balanced diet (ICMR-NIN, 2020). The guidelines indicate that pulses can be replaced with animal-source foods for non-vegetarians. Thus, for this Data Note we constructed an additional indicator –daily consumption of pulses or egg or fish or chicken or meat –to estimate any protein consumption (Figure 1). Estimates are first presented at the national level to provide an overall view of how diets have changed from 2005-06 to 2019-21. On subsequent pages, we show trends between 2015-16 and 2019-21 by state and district. USE| This data note provides a broad view of diet patterns among adults and should be used for further inquiry by stakeholders including researchers, policymakers, and program staff at multiple levels. We recognize that NFHS is not a detailed dietary survey and does not ask about individual food items or the quantity of food consumed. Thus, this data note should be used as a starting point for discussion and to identify major areas of improvement in consumption and measurement

Microwave accelerated synthesis of 2-aminothiophenes in ionic liquid <i style="">via</i> three component Gewald reaction

653-657Microwave accelerated synthesis of substituted 2-amino­thiophenes by a three-component Gewald reaction using a basic ionic liquid, 1,1,3,3-tetramethylguanidine lactate [TMG] [Lac] as solvent as well as catalyst has been developed. The products are obtained in good to high yields and the ionic liquid is reusable over several cycles without significant loss in catalytic activity