17,198 research outputs found
Inflammation and changes in cytokine levels in neurological feline infectious peritonitis.
Feline infectious peritonitis (FIP) is a progressive, fatal, predominantly Arthus-type immune-mediated disease that is triggered when cats are infected with a mutant enteric coronavirus. The disease presents variably with multiple organ failure, seizures, generalized effusion, or shock. Neurological FIP is clinically and pathologically more homogeneous than systemic 'wet' or 'dry' FIP; thus, comparison of cytokine profiles from cats with neurological FIP, wet FIP, and non-FIP neurological disease may provide insight into some baseline characteristics relating to the immunopathogenesis of neurological FIP. This study characterizes inflammation and changes in cytokines in the brain tissue of FIP-affected cats. Cellular infiltrates in cats with FIP included lymphocytes, plasma cells, neutrophils, macrophages, and eosinophils. IL-1 beta, IL-6, IL-12, IL-18, TNF-alpha, macrophage inhibitory protein (MIP)-1 alpha, and RANTES showed no upregulation in the brains of control cats, moderate upregulation in neurological FIP cats, and very high upregulation in generalized FIP cats. Transcription of IFN-gamma appeared upregulated in cats with systemic FIP and slightly downregulated in neurological FIP. In most cytokines tested, variance was extremely high in generalized FIP and much less in neurological FIP. Principal components analysis was performed in order to find the least number of 'components' that would summarize the cytokine profiles in cats with neurological FIP. A large component of the variance (91.7%) was accounted for by levels of IL-6, MIP-1 alpha, and RANTES. These findings provide new insight into the immunopathogenesis of FIP and suggest targets for immune therapy of this disease
Calibration of the Mass-Temperature Relation for Clusters of Galaxies Using Weak Gravitational Lensing
The main uncertainty in current determinations of the power spectrum
normalization, sigma_8, from abundances of X-ray luminous galaxy clusters
arises from the calibration of the mass-temperature relation. We use our weak
lensing mass determinations of 30 clusters from the hitherto largest sample of
clusters with lensing masses, combined with X-ray temperature data from the
literature, to calibrate the normalization of this relation at a temperature of
8 keV, M_{500c,8 keV}=(8.7 +/- 1.6) h^{-1} 10^{14} M_sun. This normalization is
consistent with previous lensing-based results based on smaller cluster
samples, and with some predictions from numerical simulations, but higher than
most normalizations based on X-ray derived cluster masses. Assuming the
theoretically expected slope alpha=3/2 of the mass-temperature relation, we
derive sigma_8 = 0.88 +/-0.09 for a spatially-flat LambdaCDM universe with
Omega_m = 0.3. The main systematic errors on the lensing masses result from
extrapolating the cluster masses beyond the field-of-view used for the
gravitational lensing measurements, and from the separation of
cluster/background galaxies, contributing each with a scatter of 20%. Taking
this into account, there is still significant intrinsic scatter in the
mass-temperature relation indicating that this relation may not be very tight,
at least at the high mass end. Furthermore, we find that dynamically relaxed
clusters are 75 +/-40% hotter than non-relaxed clusters.Comment: 8 pages, 4 figures, revised version submitted to Ap
Peculiarities of the stacks with finite number of intrinsic Josephson junctions
We study the breakpoint region on the outermost branch of current-voltage
characteristics of the stacks with different number of intrinsic Josephson
junctions. We show that at periodic boundary conditions the breakpoint region
is absent for stacks with even number of junctions. For stacks with odd number
of junctions and for stacks with nonperiodic boundary conditions the breakpoint
current is increased with number of junctions and saturated at the value
corresponding to the periodic boundary conditions. The region of saturation and
the saturated value depend on the coupling between junctions. We explain the
results by the parametric resonance at the breakpoint and excitation of the
longitudinal plasma wave by the Josephson oscillations. A way for the
diagnostics of the junctions in the stack is proposed.Comment: 4 pages, 5 figure
Deformation of LeBrun's ALE metrics with negative mass
In this article we investigate deformations of a scalar-flat K\"ahler metric
on the total space of complex line bundles over CP^1 constructed by C. LeBrun.
In particular, we find that the metric is included in a one-dimensional family
of such metrics on the four-manifold, where the complex structure in the
deformation is not the standard one.Comment: 20 pages, no figure. V2: added two references, filled a gap in the
proof of Theorem 1.2. V3: corrected a wrong statement about Kuranishi family
of a Hirzebruch surface stated in the last paragraph in the proof of Theorem
1.2, and fixed a relevant error in the proof. Also added a reference [24]
about Kuranishi family of Hirzebruch surface
High-field vortices in Josephson junctions with alternating critical current density
We study long Josephson junctions with the critical current density
alternating along the junction. New equilibrium states, which we call the field
synchronized or FS states, are shown to exist if the applied field is from
narrow intervals centered around equidistant series of resonant fields, .
The values of are much higher than the flux penetration field, . The
flux per period of the alternating critical current density, , is fixed
for each of the FS states. In the -th FS state the value of is
equal to an integer amount of flux quanta, . Two types of
single Josephson vortices carrying fluxes or/and can exist
in the FS states. Specific stepwise resonances in the current-voltage
characteristics are caused by periodic motion of these vortices between the
edges of the junction.Comment: 4 pages, 5 figure
Slow-light enhanced optical detection in liquid-infiltrated photonic crystals
Slow-light enhanced optical detection in liquid-infiltrated photonic crystals
is theoretically studied. Using a scattering-matrix approach and the
Wigner-Smith delay time concept, we show that optical absorbance benefits both
from slow-light phenomena as well as a high filling factor of the energy
residing in the liquid. Utilizing strongly dispersive photonic crystal
structures, we numerically demonstrate how liquid-infiltrated photonic crystals
facilitate enhanced light-matter interactions, by potentially up to an order of
magnitude. The proposed concept provides strong opportunities for improving
existing miniaturized absorbance cells for optical detection in lab-on-a-chip
systems.Comment: Paper accepted for the "Special Issue OWTNM 2007" edited by A.
Lavrinenko and P. J. Robert
Urban Lymphatic Filariasis in the Metropolis of\ud Dar es Salaam, Tanzania
The last decades have seen a considerable increase in urbanization in Sub-Saharan Africa, and it is estimated that over 50% of the population will live in urban areas by 2040. Rapid growth of cities combined with limited economic resources often result in informal settlements and slums with favorable conditions for proliferation of vectors of lymphatic filariasis (LF). In Dar es Salaam, which has grown more than 30 times in population during the past 55 years (4.4 million inhabitants in 2012), previous surveys have indicated high prevalences of LF. This study investigated epidemiological aspects of LF in Dar es Salaam, as a background for planning and implementation of control. Six sites with varying distance from the city center (3–30 km) and covering different population densities, socioeconomic characteristics, and water, sewerage and sanitary facilities were selected for the study. Pupils from one public primary school at each site were screened for circulating filarial antigen (CFA; marker of adult worm infection) and antibodies to Bm14 (marker of exposure to transmission). Community members were examined for CFA, microfilariae and chronic manifestations. Structured questionnaires were administered to pupils and heads of community households, and vector surveys were carried out in selected households. The study indicated that a tremendous decrease in the burden of LF infection had occurred, despite haphazard urbanisation. Contributing factors may be urban malaria control targeting Anopheles vectors, short survival time of the numerous Culex quinquefasciatus vectors in the urban environment, widespread use of bed nets and other mosquito proofing measures, and mass drug administration (MDA) in 2006 and 2007. Although the level of ongoing transmission was low, the burden of chronic LF disease was still high. The development has so far been promising, but continued efforts are necessary to ensure elimination of LF as a public health problem. These will include improving the awareness of people about the role of mosquitoes in transmission of LF, more thorough implementation of environmental sanitation to reduce Cx. Quinquefasciatus breeding, continued MDA to high-risk areas, and set-up of programmes for management of chronic LF disease
Frequency response in surface-potential driven electro-hydrodynamics
Using a Fourier approach we offer a general solution to calculations of slip
velocity within the circuit description of the electro-hydrodynamics in a
binary electrolyte confined by a plane surface with a modulated surface
potential. We consider the case with a spatially constant intrinsic surface
capacitance where the net flow rate is in general zero while harmonic rolls as
well as time-averaged vortex-like components may exist depending on the spatial
symmetry and extension of the surface potential. In general the system displays
a resonance behavior at a frequency corresponding to the inverse RC time of the
system. Different surface potentials share the common feature that the
resonance frequency is inversely proportional to the characteristic length
scale of the surface potential. For the asymptotic frequency dependence above
resonance we find a 1/omega^2 power law for surface potentials with either an
even or an odd symmetry. Below resonance we also find a power law omega^alpha
with alpha being positive and dependent of the properties of the surface
potential. Comparing a tanh potential and a sech potential we qualitatively
find the same slip velocity, but for the below-resonance frequency response the
two potentials display different power law asymptotics with alpha=1 and
alpha~2, respectively.Comment: 4 pages including 1 figure. Accepted for PR
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