New Measurements of Venus Winds with Ground-Based Doppler Velocimetry at CFHT

operations with observations from the ground using various techniques and spectral domains (Lellouch and Witasse, 2008). We present an analysis of Venus Doppler winds at cloud tops based on observations made at the Canada France Hawaii 3.6-m telescope (CFHT) with the ESPaDOnS visible spectrograph. These observations consisted of high-resolution spectra of Fraunhofer lines in the visible range (0.37-1.05 μm) to measure the winds at cloud tops using the Doppler shift of solar radiation scattered by cloud top particles in the observer's direction (Widemann et al., 2007, 2008). The observations were made during 19-20 February 2011 and were coordinated with Visual Monitoring Camera (VMC) observations by Venus Express. The complete optical spectrum was collected over 40 spectral orders at each point with 2-5 seconds exposures, at a resolution of about 80000. The observations included various points of the dayside hemisphere at a phase angle of 67°, between +10° and -60° latitude, in steps of 10° , and from +70° to -12° longitude relative to sub-Earth meridian in steps of 12°. The Doppler shift measured in scattered solar light on Venus dayside results from two instantaneous motions: (1) a motion between the Sun and Venus upper cloud particles; (2) a motion between the observer and Venus clouds. The measured Doppler shift, which results from these two terms combined, varies with the planetocentric longitude and latitude and is minimum at meridian ΦN = ΦSun - ΦEarth where the two components subtract to each other for a pure zonal regime. Due to the need for maintaining a stable velocity reference during the course of acquisition using high resolution spectroscopy, we measure relative Doppler shifts to ΦN. The main purpose of our work is to provide variable wind measurements with respect to the background atmosphere, complementary to simultaneous measurements made with the VMC camera onboard the Venus Express. We will present first results from this work, comparing with previous results by the CFHT/ESPaDOnS and VLT-UVES spectrographs (Machado et al., 2012), with Galileo fly-by measurements and with VEx nominal mission observations (Peralta et al., 2007, Luz et al., 2011). Acknowledgements: The authors acknowledge support from FCT through projects PTDC/CTE-AST/110702/2009 and PEst-OE/FIS/UI2751/2011. PM and TW also acknowledge support from the Observatoire de Paris. Lellouch, E., and Witasse, O., A coordinated campaign of Venus ground-based observations and Venus Express measurements, Planetary and Space Science 56 (2008) 1317-1319. Luz, D., et al., Venus's polar vortex reveals precessing circulation, Science 332 (2011) 577-580. Machado, P., Luz, D. Widemann, T., Lellouch, E., Witasse, O, Characterizing the atmospheric dynamics of Venus from ground-based Doppler velocimetry, Icarus, submitted. Peralta J., R. Hueso, A. Sánchez-Lavega, A reanalysis of Venus winds at two cloud levels from Galileo SSI images, Icarus 190 (2007) 469-477. Widemann, T., Lellouch, E., Donati, J.-F., 2008, Venus Doppler winds at Cloud Tops Observed with ESPaDOnS at CFHT, Planetary and Space Science, 56, 1320-1334

The origin of late archaean granitoids in the Sukumaland greenstone belt of Northern Tanzania: geochemical and isotopic constraints

Granitoids intruding the late Archaean sequences of the Sukumaland Greenstone Belt of northern Tanzania belong to two distinct geochemical suites. Suite 1 is characterised by Na2O/K2O > 1 (1.04 – 4.67), high Sr/Y (56 – 204) and Ba/Rb ratios (6.1 – 27.1) and low Rb/Sr ratios (0.08 - 0.25). The rocks are enriched in Sr (405 – 1264 ppm) and depleted in Yb (0.17 – 0.93 ppm) and Rb (56 – 132 ppm). On chondrite-normalised REE diagrams, the rocks display highly fractionated patterns characterised by relative LREE enrichment ((La/Yb)N = 23 – 128 and (Gd/Yb)N = 3.10 – 8.54) and lower concentrations of the HREE (YbN = 0.80 – 4.45). On primitive mantle-normalised spidergrams, Nb and Ti, together with P and Y are depleted relative to adjacent elements. The major and trace element characteristics of Suite 1 are comparable to those of typical Archaean TTG suites and High Silica Adakites (HSA). Suite 2 granitoids are characterised by Na2O/K2O < 1, low Sr/Y (2.80 – 41.7) and Ba/Rb (0.40 – 8.91) ratios and high Rb/Sr (0.30 – 6.27) ratios. Suite 2 is also characterised by low Sr (53 - 326 ppm) and high Rb (40 - 365 ppm) and Yb (0.44 – 1.36 ppm) contents. Compared to Suite 1, Suite 2 rocks display less fractionated REE patterns ((La/Yb)N = 15 – 86 and (Gd/Yb)N = 1.73 – 6.74) and are characterised by higher concentrations of the HREE (YbN = 2.1 – 6.5). On primitive mantle-normalised spidergrams, Suite 2 samples, like those of Suite 1, show relative depletion in Th, Nb and Ti, together with P and Y relative to adjacent elements. Sm-Nd mean crustal residence ages for both suites are indistinguishable and range between 2470 and 2720 Ma with a mean of 2610 &#61617; 35 Ma (2 SE), similar to the emplacement age of 2620 &#61617; 40 Ma. The granitoids are interpreted to have formed by partial melting at the base of a late Archaean thickened sub-arc basaltic crust. Melting to form the Suite 1 granitoids occurred in the eclogite stability field whereas Suite 2 formed by melting at shallower depth in the garnet amphibolite stability field. Tanzania Journal of Science Vol. 32 (1) 2006: pp. 75-8

Generation of fusion protein EGFRvIII-HBcAg and its anti-tumor effect in vivo

The epidermal growth factor receptor variant III (EGFRvIII) is the most common variation of EGFR. Because it shows a high frequency in several different types of tumor and has not been detected in normal tissues, it is an ideal target for tumor specific therapy. In this study, we prepared EGFRvIII-HBcAg fusion protein. After immunization with fusion protein, HBcAg or PBS, the titers of antibody in BALB/c mice immunized with fusion protein reached 2.75 × 105. Western blot analysis demonstrated that the fusion protein had specific antigenicity against anti-EGFRvIII antibody. Further observation showed fusion protein induced a high frequency of IFN-γ-secreting lymphocytes. CD4+T cells rather than CD8+T cells were associated with the production of IFN-γ. Using Renca-vIII(+) cell as specific stimulator, we observed remarkable cytotoxic activity in splenocytes from mice immunized with fusion protein. Mice were challenged with Renca-vIII(+) cells after five times immunization. In fusion protein group, three of ten mice failed to develop tumor and all survived at the end of the research. The weight of tumors in fusion protein were obviously lighter than that in other two groups (t = 4.73, P = 0.044;t = 6.89, P = 0.040). These findings demonstrated that EGFRvIII-HBcAg fusion protein triggered protective responses against tumor expressing EGFRvIII

Allogeneic blood transfusion and prognosis following total hip replacement: a population-based follow up study

<p>Abstract</p> <p>Background</p> <p>Allogeneic red blood cell transfusion is frequently used in total hip replacement surgery (THR). However, data on the prognosis of transfused patients are sparse. In this study we compared the risk of complications following THR in transfused and non-transfused patients.</p> <p>Methods</p> <p>A population-based follow-up study was performed using data from medical databases in Denmark. We identified 28,087 primary THR procedures performed from 1999 to 2007, from which we computed a propensity score for red blood cell transfusion based on detailed data on patient-, procedure-, and hospital-related characteristics. We were able to match 2,254 transfused with 2,254 non-transfused THR patients using the propensity score.</p> <p>Results</p> <p>Of the 28,087 THR patients, 9,063 (32.3%) received at least one red blood cell transfusion within 8 days of surgery. Transfused patients had higher 90-day mortality compared with matched non-transfused patients: the adjusted OR was 2.2 (95% confidence interval (CI): 1.2-3.8). Blood transfusion was also associated with increased odds of pneumonia (OR 2.1; CI: 1.2-3.8), whereas the associations with cardiovascular or cerebrovascular events (OR 1.4; CI: 0.9-2.2) and venous thromboembolism (OR 1.2; CI: 0.7-2.1) did not reach statistical significance. The adjusted OR of reoperation due to infection was 0.6 (CI: 0.1-2.9).</p> <p>Conclusions</p> <p>Red blood cell transfusion was associated with an adverse prognosis following primary THR, in particular with increased odds of death and pneumonia. Although the odds estimates may partly reflect unmeasured bias due to blood loss, they indicate the need for careful assessment of the risk versus benefit of transfusion even in relation to routine THR procedures.</p

Modulation of the virus-receptor interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody

&lt;b&gt;BACKGROUND:&lt;/b&gt; In the acute phase of infection with feline immunodeficiency virus (FIV), the virus targets activated CD4+ T cells by utilising CD134 (OX40) as a primary attachment receptor and CXCR4 as a co-receptor. The nature of the virus-receptor interaction varies between isolates; strains such as GL8 and CPGammer recognise a "complex" determinant on CD134 formed by cysteine-rich domains (CRDs) 1 and 2 of the molecule while strains such as PPR and B2542 require a more "simple" determinant comprising CRD1 only for infection. These differences in receptor recognition manifest as variations in sensitivity to receptor antagonists. In this study, we ask whether the nature of the virus-receptor interaction evolves in vivo.&lt;p&gt;&lt;/p&gt; &lt;b&gt;RESULTS:&lt;/b&gt; Following infection with a homogeneous viral population derived from a pathogenic molecular clone, a quasispecies emerged comprising variants with distinct sensitivities to neutralising antibody and displaying evidence of conversion from a "complex" to a "simple" interaction with CD134. Escape from neutralising antibody was mediated primarily by length and sequence polymorphisms in the V5 region of Env, and these alterations in V5 modulated the virus-receptor interaction as indicated by altered sensitivities to antagonism by both anti-CD134 antibody and soluble CD134.&lt;p&gt;&lt;/p&gt; &lt;b&gt;CONCLUSIONS:&lt;/b&gt; The FIV-receptor interaction evolves under the selective pressure of the host humoral immune response, and the V5 loop contributes to the virus-receptor interaction. Our data are consistent with a model whereby viruses with distinct biological properties are present in early versus late infection and with a shift from a "complex" to a "simple" interaction with CD134 with time post-infection.&lt;p&gt;&lt;/p&gt

Current concepts of the management of dental extractions for patients taking warfarin

The document attached has been archived with permission from the Australian Dental Association. An external link to the publisher’s copy is included.Background: Controversy has surrounded the correct management of patients therapeutically anticoagulated with warfarin who require dental extractions. The risk of bleeding must be weighed up against the risk of thromboembolism when deciding whether to interfere with a patient's warfarin regimen. An improved understanding of the importance of fibrinolytic mechanisms in the oral cavity has resulted in the development of various local measures to enable these patients to be treated on an outpatient basis. Methods: A review of the literature was undertaken. This was supplemented by the authors' clinical trials and extensive clinical experience with anticoagulated patients. Results: Various protocols for treating patients taking warfarin have been reviewed and summarized and an overview of the haemostatic and fibrinolytic systems is presented. A protocol for management of warfarinized patients requiring dental extractions in the outpatient setting is proposed. Conclusions: Patients therapeutically anticoagulated with warfarin can be treated on an ambulatory basis, without interruption of their warfarin regimen provided appropriate local measures are used.G Carter, AN Goss, JV Lloyd, R Tocchett

Risk measures for direct real estate investments with non-normal or unknown return distributions

The volatility of returns is probably the most widely used risk measure for real estate. This is rather surprising since a number of studies have cast doubts on the view that volatility can capture the manifold risks attached to properties and corresponds to the risk attitude of investors. A central issue in this discussion is the statistical properties of real estate returns—in contrast to neoclassical capital market theory they are mostly non-normal and often unknown, which render many statistical measures useless. Based on a literature review and an analysis of data from Germany we provide evidence that volatility alone is inappropriate for measuring the risk of direct real estate. We use a unique data sample by IPD, which includes the total returns of 939 properties across different usage types (56% office, 20% retail, 8% others and 16% residential properties) from 1996 to 2009, the German IPD Index, and the German Property Index. The analysis of the distributional characteristics shows that German real estate returns in this period were not normally distributed and that a logistic distribution would have been a better fit. This is in line with most of the current literature on this subject and leads to the question which indicators are more appropriate to measure real estate risks. We suggest that a combination of quantitative and qualitative risk measures more adequately captures real estate risks and conforms better with investor attitudes to risk. Furthermore, we present criteria for the purpose of risk classification

Cost analysis of two anaesthetic machines: "Primus®" and "Zeus®"

Background Two anaesthetic machines, the "Primus&#174;" and the "Zeus&#174;" (Draeger AG, L&#252;beck, Germany), were subjected to a cost analysis by evaluating the various expenses that go into using each machine. Methods These expenses included the acquisition, maintenance, training and device-specific accessory costs. In addition, oxygen, medical air and volatile anaesthetic consumption were determined for each machine. Results Anaesthesia duration was 278 &#177; 140 and 208 &#177; 112 minutes in the Primus&#174; and the Zeus&#174;, respectively. The purchase cost was &#8364;3.28 and &#8364;4.58 per hour of operation in the Primus&#174; and the Zeus&#174;, respectively. The maintenance cost was &#8364;0.90 and &#8364;1.20 per hour of operation in the Primus&#174; and the Zeus&#174;, respectively. We found that the O2 cost was &#8364;0.015 &#177; 0.013 and &#8364;0.056 &#177; 0.121 per hour of operation in the Primus&#174; and the Zeus&#174;, respectively. The medical air cost was &#8364;0.005 &#177; 0.003 and &#8364;0.016 &#177; 0.027 per hour of operation in the Primus&#174; and the Zeus&#174;, respectively. The volatile anaesthetic cost was &#8364;2.40 &#177; 2.40 and &#8364;4.80 &#177; 4.80 per hour of operation in the Primus&#174; and the Zeus&#174;, respectively. Conclusion This study showed that the "Zeus&#174;" generates a higher cost per hour of operation compared to the "Primus&#174;"

Are all prognostic factors in parotid gland carcinoma well recognized?

The aim of his study was to assess the treatment results and prognostic factors in patients with parotid gland carcinoma. The material consisted of 109 patients treated surgically, with or without complementary radiotherapy, between 1978 and 2008 (follow-up at least 5-years). 5-year overall and disease-specific survival were observed in 57.0% of the patients and 5-year disease-free survival was achieved in 50.0%. Univariate analysis including ten clinical and pathological features to assess their prognostic value was done. Parapharyngeal space invasion, facial nerve palsy, and high grade of tumor malignancy were the factors with the highest influence on the treatment results, because their presence decreased the chance for recovery 9.8, 9.7, and 8.2 times, respectively. Histologically positive cervical lymph nodes and extraparenchymal extension were the other factors connected with poor prognosis (prognosis worse 6.7 and 5.4 times, respectively). Clinically positive cervical lymph nodes, positive/uncertain microscopic margin, involvement of the deep lobe, or the whole gland increased the risk of treatment failure 3.4, 3.1, and 2.8, respectively. The age ≥60 years and male gender were statistically significant factors, correlated with poor prognosis and decreased chance for recovery 2.4 and 2.6 times. T-status and clinical stage had important influence on 5-year disease-free survival rate because there were significant differences in the treatment results between individual stages. Multivariate analysis proved that the independent prognostic value, among anatomic structures involved by the neoplasm, had mandible, facial nerve, and skin infiltration. Among tumor-related factors, T-stage and grade had the statistically significant influence on treatment results, and stage and lymph nodes metastases among clinical and pathological features. These results confirm the value of actually used TNM classification (2002). Although the parapharyngeal space invasion is a factor, which seems to have a significant, poor prognostic value, it was not included in this classification