Large N lattice QCD and its extended strong-weak connection to the hypersphere

We calculate an effective Polyakov line action of QCD at large Nc and large Nf from a combined lattice strong coupling and hopping expansion working to second order in both, where the order is defined by the number of windings in the Polyakov line. We compare with the action, truncated at the same order, of continuum QCD on S^1 x S^d at weak coupling from one loop perturbation theory, and find that a large Nc correspondence of equations of motion found in \cite{Hollowood:2012nr} at leading order, can be extended to the next order. Throughout the paper, we review the background necessary for computing higher order corrections to the lattice effective action, in order to make higher order comparisons more straightforward.Comment: 33 pages, 7 figure

Calculating the chiral condensate diagrammatically at strong coupling

We calculate the chiral condensate of QCD at infinite coupling as a function of the number of fundamental fermion flavours using a lattice diagrammatic approach inspired by recent work of Tomboulis, and other work from the 80's. We outline the approach where the diagrams are formed by combining a truncated number of sub-diagram types in all possible ways. Our results show evidence of convergence and agreement with simulation results at small Nf. However, contrary to recent simulation results, we do not observe a transition at a critical value of Nf. We further present preliminary results for the chiral condensate of QCD with symmetric or adjoint representation fermions at infinite coupling as a function of Nf for Nc = 3. In general, there are sources of error in this approach associated with miscounting of overlapping diagrams, and over-counting of diagrams due to symmetries. These are further elaborated upon in a longer paper.Comment: presented at the 32nd International Symposium on Lattice Field Theory (Lattice 2014), 23-28 June 2014, New York, NY, US

Calculating the chiral condensate of QCD at infinite coupling using a generalised lattice diagrammatic approach

We develop a lattice diagrammatic technique for calculating the chiral condensate of QCD at infinite coupling inspired by recent work of Tomboulis and earlier work from the 80's. The technique involves calculating the contribution of gauge link diagrams formed from all possible combinations of a number of sub-diagram types. This is achieved by performing a resummation, using a truncated number of sub-diagram types. We show how to calculate the relevant sub-diagrams, including a new technique for evaluating group integrals with arbitrary number of gauge link elements, using Young Projectors. Including up to four different diagram types we calculate the chiral condensate as a function of Nf, and show that two real solutions result, which are non-zero for all integer Nf. We analyse these solutions and find signs of convergence of the expansion at small Nf. We discuss sources of error associated with this approach in detail and implement a technique to reduce over-counting of diagrams.Comment: 47 pages, including 2 appendices, 10 plot

Singly-resonant sum frequency generation of visible light in a semiconductor disk laser

In this paper a generic approach for visible light generation is presented. It is based on sum frequency generation between a semiconductor disk laser and a solid-state laser, where the frequency mixing is achieved within the cavity of the semiconductor disk laser using a singlepass of the solid-state laser light. This exploits the good beam quality and high intra-cavity power present in the semiconductor disk laser to achieve high conversion efficiency. Combining sum frequency mixing and semiconductor disk lasers in this manner allows in principle for generation of any wavelength within the visible spectrum, by appropriate choice of semiconductor material and single-pass laser wavelength

Does macrolide use confer risk of out-of-hospital cardiac arrest compared with penicillin V? A Danish national case-crossover and case–time–control study

Introduction and objectivesMacrolides have been associated with proarrhythmic properties, but the evidence is conflicting. We evaluated the risk of out-of-hospital cardiac arrest (OHCA) associated with specific macrolides in a retrospective study. Associations between specific macrolides and OHCA were examined by conditional logistic regression analyses in case-crossover and case–time–control models, using penicillin-V treatment as the comparative reference. From nationwide registries, we identified all OHCAs in Denmark from 2001 to 2010 and use of antibiotics.EthicsThe present study was approved by the Danish Data Protection Agency (Danish Data Protection Agency (ref.no. 2007-58-0015, local ref.no. GEH-2014-017, (I-Suite.nr. 02 735)).ParticipantsWe identified 29 111 patients with an OHCA. Of these, 514 were in macrolide treatment ≤7 days before OHCA and 1237 in penicillin-V treatment.ResultsIn the case-crossover analyses, overall macrolide use was not associated with OHCA with penicillin V as negative comparative reference (OR=0.90; 95% CI 0.73 to 1.10). Compared with penicillin-V treatment, specific macrolides were not associated with increased risk of OHCA: roxithromycin (OR=0.97; 95% CI 0.74 to 1.26), erythromycin (OR=0.68; 95% CI 0.44 to 1.06), clarithromycin (OR=0.95; 95% CI 0.61 to 1.48) and azithromycin (OR=0.85; 95% CI 0.57 to 1.27).Similar results were obtained using case–time–control models: overall macrolide use (OR=0.81; 95% CI 0.62 to 1.06) and specific macrolides (roxithromycin(OR=0.70; 95% CI 0.49 to 1.00), erythromycin(OR=0.67; 95% CI 0.38 to 1.18), clarithromycin(OR=0.75; 95% CI 0.41 to 1.39) or azithromycin(OR=1.17; 95% CI 0.70 to 1.95)).ConclusionThe risk of OHCA during treatment with macrolides was similar to that of penicillin V, suggesting no additional risk of OHCA associated with macrolides.</jats:sec

Targeting endogenous retroviruses using a novel adenoviral vaccine technology

Human Endogenous Retroviruses (HERVs) are promising cancer vaccine targets as they are reactivated in cancers while being silent in healthy tissues. Around 8-9% of our genome is made up of HERVs and reactivation of HERVs, especially HERV-K, have been implicated in tumorigenesis via oncogenic signaling and immune evasion. As one of the means for cancer immune evasion, HERVs utilize an Immune Suppressive Domain (ISD) located in their envelope protein (Env). Here, our cancer vaccine strategy was to evaluate if adenoviral vaccines encoding a virus-like particle immunogen design including Gag for particle formation and an ISD mutated Env protein (ISDmut) as a surface target, could induce potent and efficacious immune responses. For this purpose, we used the adenoviral vectors hAd19a and hAd5. Please click Download on the upper right corner to see the full abstract