Implantable Controlled Release Device to Deliver Drugs Directly To an Internal Portion of the Body

A simple and implantable sustained release drug delivery device with an inner core containing an effective amount of a low solubility agent covered by a non-bioerodible polymer coating layer that is permeable to the low solubility agent is disclosed. A method for treating a mammal to obtain a desired local or systemic physiological or pharmacological effect by surgically implanting such a sustained release drug delivery device into a mammal in need of treatment is also disclosed

Implantable Controlled Release Device to Deliver Drugs Directly to an Internal Portion of the Body

A simple and implantable sustained release drug delivery device with an inner core containing an effective amount of a low solubility agent covered by a non-bioerodible polymer coating layer that is permeable to the low solubility agent is disclosed. A method for treating a mammal to obtain a desired local or systemic physiological or pharmacological effect by surgically implanting such a sustained release drug delivery device into a mammal in need of treatment is also disclosed

Sustained Release Drug Delivery Devices

A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir comprising the effective agent; a first coating layer, which is essentially impermeable to the passage of the effective agent; and a second coating layer, which is permeable to the passage of the effective agent. The first coating layer covers at least a portion of the inner core; however, at least a small portion of the inner core is not coated with the first coating layer. The second coating layer essentially completely covers the first coating layer and the uncoated portion of the inner core

A revised tropical to subtropical paleogene planktonic foraminiferal zonation

Author Posting. © Cushman Foundation for Foraminiferal Research, 2005. This article is posted here by permission of Cushman Foundation for Foraminiferal Research for personal use, not for redistribution. The definitive version was published in Journal of Foraminiferal Research 35 (2005): 279-298, doi:10.2113/35.4.279.New biostratigraphic investigations on deep sea cores and outcrop sections have revealed several shortcomings in currently used tropical to subtropical Eocene planktonic foraminiferal zonal schemes in the form of: 1) modified taxonomic concepts, 2) modified/different ranges of taxa, and 3) improved calibrations with magnetostratigraphy. This new information provides us with an opportunity to make some necessary improvements to existing Eocene biostratigraphic schemes. At the same time, we provide an alphanumeric notation for Paleogene zones using the prefix ‘P’ (for Paleocene), ‘E’ (for Eocene) and ‘O’ (for Oligocene) to achieve consistency with recent short-hand notation for other Cenozoic zones (Miocene [’M’], Pliocene [PL] and Pleistocene [PT]). Sixteen Eocene (E) zones are introduced (or nomenclaturally emended) to replace the 13 zones and subzones of Berggren and others (1995). This new zonation serves as a template for the taxonomic and phylogenetic studies in the forthcoming Atlas of Eocene Planktonic Foraminifera (Pearson and others, in press). The 10 zones and subzones of the Paleocene (Berggren and others, 1995) are retained and renamed and/or emended to reflect improved taxonomy and an updated chronologic calibration to the Global Polarity Time Scale (GPTS) (Berggren and others, 2000). The Paleocene/Eocene boundary is correlated with the lowest occurrence (LO) of Acarinina sibaiyaensis (base of Zone E1), at the top of the truncated and redefined (former) Zone P5. The five-fold zonation of the Oligocene (Berggren and others, 1995) is modified to a six-fold zonation with the elevation of (former) Subzones P21a and P21b to zonal status. The Oligocene (O) zonal components are renamed and/or nomenclaturally emended

Shifting sands: the narrative construction of early career aboriginal teachers' professional identities at the cultural interface

This study explores issues facing early career Aboriginal teachers as they construct and enact their personal, professional and situated identities when learning to teach. Narrative constructions of identity simultaneously illuminate and challenge dominant discourses about Aboriginal teachers as they take up, resist and/or reject these discourses. The role of Aboriginality is mediated by factors such as lived experience, positioning of and by the teachers and school contexts. These issues are explored through the theoretical perspectives of Foucault, Bourdieu and Nakata. Like shifting sands, identity construction and teaching work can be unstable terrain, requiring complex contextualised understandings, skills and dispositions. Participants are pre-service Aboriginal teachers in an away-from-base secondary Aboriginal Studies teacher education program at the University of Sydney. They are mature-aged with varying levels of experience of formal education and living in Aboriginal communities. Using narrative methodology, eleven in-depth conversational interviews followed by two focus groups revealed emerging storylines and themes and four participants were identified for further interviews to collaboratively construct the final narratives. This approach privileged participant voices and created spaces to articulate the tacit knowledge and understandings that contribute to the development of a professional identity drawn from personal, professional, cultural and contextual sources. Three themes emerged: discourses of Aboriginality, narratives of belonging, and conceptualising a pedagogical cultural identity. The implications of these themes bring focus to pre-service and in-service teacher professional learning based on valuing Aboriginal community engagement. When nurtured early in a teacher’s career, relationships serve a socio-cultural and political role that contribute significantly to the development of agentic and resilient identities at the cultural interface

Iterative evolution of digitate planktonic foraminifera

Digitate shell morphologies have evolved repeatedly in planktonic foraminifera throughout the Cretaceous and Cenozoic. Digitate species are usually rare in fossil and modern assemblages but show increased abundance and diversity at times during the Cretaceous and mid- dle Eocene. In this paper we discuss the morphology and stratigraphic distribution of digitate planktonic foraminifera and establish the isotopic depth ecology of fossil ones to draw parallels with modern counterparts

Temperature dependency of metabolic rates in the upper ocean: A positive feedback to global climate change?

The temperature of seawater can affect marine plankton in various ways, including by affecting rates of metabolic processes. This can change the way carbon and nutrients are fixed and recycled and hence the chemical and biological profile of the water column. A variety of feedbacks on global climate are possible, especially by altering patterns of uptake and return of carbon dioxide to the atmosphere. Here we summarize and synthesize recent studies in the field of ecology, oceanography and ocean carbon cycling pertaining to possible feedbacks involving metabolic processes. By altering the rates of cellular growth and respiration, temperature-dependency may affect nutrient uptake and food demand in plankton and ultimately the equilibrium of pelagic food webs, with cascade effects on the flux of organic carbon between the upper and inner ocean (the “biological carbon pump”) and the global carbon cycle. Insights from modern ecology can be applied to investigate how temperature-dependent changes in ocean biogeochemical cycling over thousands to millions of years may have shaped the long-term evolution of Earth's climate and life. Investigating temperature-dependency over geological time scales, including through globally warm and cold climate states, can help to identify processes that are relevant for a variety of future scenarios

Calibration of key temperature-dependent ocean microbial processes in the cGENIE.muffin Earth system model

Temperature is a master parameter in the marine carbon cycle, exerting a critical control on the rate of biological transformation of a variety of solid and dissolved reactants and substrates. Although in the construction of numerical models of marine carbon cycling, temperature has been long-recognised as a key parameter in the production and export of organic matter at the ocean surface, it is much less commonly taken into account in the ocean interior. There, bacteria (primarily) transform sinking particulate organic matter into its dissolved constituents and thereby consume dissolved oxygen (and/or other electron acceptors such as sulphate) and release nutrients, which are then available for transport back to the surface. Here we present and calibrate a more complete temperature-dependent representation of marine carbon cycling in the cGENIE.muffin Earth system model, intended for both past and future climate applications. In this, we combine a temperature-dependent remineralisation scheme for sinking organic matter with a biological export production scheme that also includes a temperature-dependent limitation on nutrient uptake in surface waters (and hence phytoplankton growth). Via a parameter ensemble, we jointly calibrate the two parameterisations by statistically contrasting model projected fields of nutrients, oxygen, and the stable carbon isotopic signature (δ13C) of dissolved inorganic carbon in the ocean, with modern observations. We find that for the present-day, the temperature-dependent version shows as-good-as or better fit to data than the existing tuned non-temperature dependent version of the cGENIE.muffin. The main impact of adding temperature-dependent remineralisation is in driving higher rates of remineralisation in warmer waters and hence a more rapid return of nutrients to the surface there – stimulating organic matter production. As a result, more organic matter is exported below 80 m in mid and low latitude warmer waters as compared to the standard model. Conversely, at higher latitudes, colder water temperature reduces the rate of nutrient supply to the surface as a result of slower in-situ rates of remineralisation. We also assess the implications of including a more complete set of temperature-dependent parameterisations by analysing a series of historical transient experiments. We find that between the pre-industrial and the present day, in response to a simulated air temperature increase of 0.9 °C and ocean warming of 0.12 °C (0.6 °C in surface waters and 0.02 °C in deep waters), a reduction in POC export at 80 m of just 0.3 % occurs. In contrast, with no assumed temperature-dependent biological processes, global POC export at 80 m falls by 2.9 % between the pre-industrial and present day as a consequence of ocean stratification and reduced nutrient supply to the surface. This suggests that increased nutrient recycling in warmer conditions offsets some of the stratification-induced surface nutrient limitation in a warmer world, and that less carbon (and nutrients) then reaches the inner and deep ocean. This extension to the cGENIE.muffin Earth system model provides it with additional capabilities in addressing marine carbon cycling in warmer past and future worlds

Sport officiating recruitment, development, and retention: A call to action

The purpose of this article is to report on the outcome of a two-day consensus-building exercise amongst sport scientists and sport practitioners interested in the recruitment, development, and retention of sport officials.  Twenty participants including volunteers and paid employees affiliated with nine Ontario-based sport organizations, university researchers, and provincial government policy makers participated.  A consensus statement regarding this aspect of sport officiating and, more specifically, “What do we know?”, “What don’t we know?”, and “Where does the research need to go from here?” is presented.  A willingness to consider and embrace these ideas may be critical in moving sport officiating from being an understudied and undervalued segment of the sport system to receiving the attention and respect it deserves going forward

Protocol for a systematic review and network meta-analysis of randomised controlled trials examining the effectiveness of early parenting interventions in preventing internalising problems in children and adolescents

Background: Internalising problems, such as depression and anxiety, are common and represent an important economical and societal burden. The effectiveness of parenting interventions in reducing the risk of internalising problems in children and adolescents has not yet been summarised. The aims of this review are to assess the effectiveness of parenting interventions in the primary, secondary and tertiary prevention of internalising problems in children and adolescents and to determine which intervention components and which intervention aspects are most effective for reducing the risk of internalising problems in children and adolescents.Methods: Electronic searches in OVID SP versions of MEDLINE, EMBASE and PsycINFO; Cochrane Central Register of Controlled Trials; EBSCO version of ERIC and ClinicalTrials.gov have been performed to identify randomised controlled trials or quasi-randomised controlled trials of parenting interventions. At least two independent researchers will assess studies for inclusion and extract data from each paper. The risk of bias assessment will be conducted independently by two reviewers using the Cochrane Collaboration's Risk of Bias Assessment Tool. Statistical heterogeneity is anticipated given potential variation in participant characteristics, intervention type and mode of delivery, and outcome measures. Random effects models, assuming a common between-study variability, will be used to account for statistical heterogeneity. Results will be analysed using a network meta-analysis (NMA). If appropriate, we will also conduct a component-level NMA, where the 'active ingredients' of interventions are modelled using a network meta-regression approach.Discussion: Preventing and reducing internalising problems could have major beneficial effects at the economic and societal level. Informing policy makers on the effectiveness of parenting interventions and on which intervention's component is driving the effect is important for the development of treatment strategies.Systematic review registration: International Prospective Register for Systematic Reviews (PROSPERO) number CRD4202017225