Personalized medicine in diabetes:The role of 'omics' and biomarkers

Personalized medicine, otherwise called stratified or precision medicine, aims to better target intervention to the individual to maximize benefit and minimize harm. This review discusses how diabetes aetiology, pathophysiology and patient genotype influence response to or side effects of the commonly used diabetes treatments. C‐peptide is a useful biomarker that is underused to guide treatment choice, severe insulin deficiency predicts non‐response to glucagon‐like peptide‐1 receptor agonists, and thiazolidinediones are more effective in insulin‐resistant patients. The field of pharmacogenetics is now yielding clinically important results, with three examples outlined: sulphonylurea sensitivity in patients with HNF1A maturity‐onset diabetes of the young; sulphonylurea sensitivity in patients with Type 2 diabetes with reduced function alleles at CYP2C9, resulting in reduced metabolism of sulphonylureas; and severe metformin intolerance associated with reduced function organic cation transporter 1 (OCT1) variants, exacerbated by drugs that also inhibit OCT1. Genome‐wide approaches and the potential of other ‘omics’, including metagenomics and metabolomics, are then outlined, highlighting the complex interacting networks that we need to understand before we can truly personalize diabetes treatments

International Negotiations on Farm Support Levels: The Role of PSEs

Agricultural and Food Policy, International Relations/Trade,

Simulated trajectories error analysis program. Volume 1 - User's manual Final report

Input/output routines and computerized simulation for error analysi

Comprehensive Organic Analysis of Antartic Micrometeorites

Introduction: Micrometeorites (MMs) are thought to be significant contributors of organic material to the early Earth [1], and a variety of techniques have been employed to identify their organic composition [2-6]. These include the identification of key organic groups using combinations of infrared, energy dispersive Xray, electron energy loss and Raman spectroscopy and scanning transmission X-ray microscopy [2-4], highlighting similarities between that of MMs and carbonaceous chondrites. Few studies, however, have focused on the characterisation of individual micrometeoritic organic components. Microscopic L2MS has been used to identify up to C5 polycyclic aromatic hydrocarbons and their alkyl derivatives [5]. A combination of ionexchange chromatography and fluorimetric detection has also been successful in identifying a number of protein amino acids including glycine and alanine [6]. We have previously reported a method to analyse ?g-sized quantities of extraterrestrial materials, with prior application to assessing organic volatile release from MM atmospheric entry heating simulations [7]. In this study we utilise this technique to characterise the organic composition of Antarctic terrestrial particles and MMs collected in 1994 from Cap-Prudhomme [8]

Sources of age determination errors for sablefish (Anoplopoma fimbria)

This study was undertaken to resolve problems in age determination of sablefish (Anoplopoma fimbria). Aging of this species has been hampered by poor agreement (averaging less than 45%) among age readers and by differences in assigned ages of as much as 15 years. Otoliths from fish that had been injected with oxytetracycline (OTC) and that had been at liberty for known durations were used to determine why age determinations were so difficult and to help determine the correct aging procedure. All fish were sampled from Oregon southwards, which represents the southern part of their range. The otoliths were examined with the aid of image processing. Some fish showed little or no growth on the otolith after eight months at liberty, whereas otoliths from other fish grew substantially. Some fish lay down two prominent hyaline zones within a single year, one in the summer and one in the winter. We classified the otoliths by morphological type and found that certain types are more likely to lay down multiple hyaline zones and other types are likely to lay down little or no zones. This finding suggests that some improvement could be achieved by detailed knowledge of the growth characteristics of the different types. This study suggests that it may not be possible to obtain reliable ages from sablefish otoliths. At the very least, more studies will be required to under-stand the growth of sablefish otoliths

Selecting children for head CT following head injury

OBJECTIVE: Indicators for head CT scan defined by the 2007 National Institute for Health and Care Excellence (NICE) guidelines were analysed to identify CT uptake, influential variables and yield. DESIGN: Cross-sectional study. SETTING: Hospital inpatient units: England, Wales, Northern Ireland and the Channel Islands. PATIENTS: Children (3 years were much more likely to have CT than those <3 years (OR 2.35 (95% CI 2.08 to 2.65)). CONCLUSION: Compliance with guidelines and diagnostic yield was variable across age groups, the type of hospital and region where children were admitted. With this pattern of clinical practice the risks of both missing intracranial injury and overuse of CT are considerable