American Grief: The AIDS Quilt and Texts of Witness

Along with fiction written from the perspective of heterosexual men caring for dying gay male friends and mothers caring for a child, this essay looks at the NAMES Project AIDS Memorial Quilt as the best known and originary AIDS text of witness, especially in the United States. The Quilt reflects the development of the concern with AIDS from being primarily that of gay men, drug users, and their companions, to a concern that belongs also to a more mainstream audience. Changing perceptions of and attitudes towards the Quilt are reflected in the fiction under analysis here. "American Grief" thus traces the development of the reading audience for fiction and other narratives about AIDS from being a primarily gay audience to a mainstream one. In this respect, it also examines the literary strategies evident in The Way We Write Now (1995), one of the first anthologies of AIDS literature. The discussion considers how AIDS literature intended for a mainstream reading public is often cast as pedagogical, thus assuming that it has something to teach its readers, rather than containing something with which they can identify. In texts by Louis Begley and Dennis McFarland this is apparent in relationships based on watching, rather than on intervention or participation or identification. Finally, the essay considers AIDS fiction by Alice Elliott Dark and Alice Hoffman that focuses on families in which one member is ill with AIDS, in terms of Jessica Benjamin's concept of intersubjectivity

Alien Registration- Annas, Pearl B. (Portland, Cumberland County)

https://digitalmaine.com/alien_docs/21288/thumbnail.jp

Immunolocalization of G protein-coupled estrogen receptor in the rat epididymis

Background Estrogen plays an important role in male reproduction, and males lacking estrogen signaling in the reproductive tissues are infertile. Estrogen signaling is mediated via two nuclear receptors, ERα and ERβ, but it was recently found that a G protein-coupled estrogen receptor (GPER) is present in the testis. It is believed that GPER is a membrane form of the estrogen receptor and mediates non-classical estrogen signaling. However, the cellular localization of GPER in the epididymis is unknown. Therefore, the objective of this study was to determine the cellular and regional expression of GPER in the rat epididymis. Findings To localize expression, immunohistochemistry (IHC) was performed using fixed epididymal tissue. Three strains and ages of rats were used to identify whether GPER expression is strain or age specific. Our results are the first to demonstrate immunostaining of GPER in epididymal epithelial cells. Expression was highest near the apical membrane followed by the cytoplasm, consistent with a membrane bound receptor. The highest expression in adult rats was observed in corpus followed by cauda. Western blotting analysis of epididymal tissues from Sprague Dawley rats confirmed specificity of the antibody and regional expression. Conclusions Expression of GPER in the corpus and cauda suggests a role for non-classical estrogen signaling in sperm maturation in the corpus, and sperm protection/storage in the cauda. GPER expression pre-pubertally suggests that estrogen may have a role in epithelial cell development in addition to regulation of adult function

CATHEDRAL: A Fast and Effective Algorithm to Predict Folds and Domain Boundaries from Multidomain Protein Structures

We present CATHEDRAL, an iterative protocol for determining the location of previously observed protein folds in novel multidomain protein structures. CATHEDRAL builds on the features of a fast secondary-structure–based method (using graph theory) to locate known folds within a multidomain context and a residue-based, double-dynamic programming algorithm, which is used to align members of the target fold groups against the query protein structure to identify the closest relative and assign domain boundaries. To increase the fidelity of the assignments, a support vector machine is used to provide an optimal scoring scheme. Once a domain is verified, it is excised, and the search protocol is repeated in an iterative fashion until all recognisable domains have been identified. We have performed an initial benchmark of CATHEDRAL against other publicly available structure comparison methods using a consensus dataset of domains derived from the CATH and SCOP domain classifications. CATHEDRAL shows superior performance in fold recognition and alignment accuracy when compared with many equivalent methods. If a novel multidomain structure contains a known fold, CATHEDRAL will locate it in 90% of cases, with <1% false positives. For nearly 80% of assigned domains in a manually validated test set, the boundaries were correctly delineated within a tolerance of ten residues. For the remaining cases, previously classified domains were very remotely related to the query chain so that embellishments to the core of the fold caused significant differences in domain sizes and manual refinement of the boundaries was necessary. To put this performance in context, a well-established sequence method based on hidden Markov models was only able to detect 65% of domains, with 33% of the subsequent boundaries assigned within ten residues. Since, on average, 50% of newly determined protein structures contain more than one domain unit, and typically 90% or more of these domains are already classified in CATH, CATHEDRAL will considerably facilitate the automation of protein structure classification

Hierarchical Models for Independence Structures of Networks

We introduce a new family of network models, called hierarchical network models, that allow us to represent in an explicit manner the stochastic dependence among the dyads (random ties) of the network. In particular, each member of this family can be associated with a graphical model defining conditional independence clauses among the dyads of the network, called the dependency graph. Every network model with dyadic independence assumption can be generalized to construct members of this new family. Using this new framework, we generalize the Erd\"os-R\'enyi and beta-models to create hierarchical Erd\"os-R\'enyi and beta-models. We describe various methods for parameter estimation as well as simulation studies for models with sparse dependency graphs.Comment: 19 pages, 7 figure

Residents’ Transformation of Dwelling Units in Public Housing Estates in Lagos, Nigeria: Implications for Policy and Practice

This study investigated the physical transformations of dwelling units in low-income housing estates in Lagos, Nigeria using the New Lagos Re-housing Estate (Phase 1) in Surulere and Federal Low-income Housing Estate in Ipaja as case studies. It was motivated by the paucity of studies on the pattern of physical transformations of dwelling units in public housing in Nigeria. A crosssectional survey of 614 household heads in these estates was carried out in 2009. It was observed that most of the respondents who were low-income earners expressed dissatisfied with their living, dining and kitchen spaces as well as bedrooms, and thus have transformed these areas of their residences. The levels of transformations were however higher in bedrooms than in other areas and were motivated by the need to create more domestic spaces and for income generation. The study implies that spontaneous transformation activities in social housing schemes can be reduced if adequate attention is given to the design of main activity areas in dwelling units, and by promoting core housing strateg

Challenges of Public Housing in a Democratic Nigeria: a Case Study of the Presidential Mandate Housing Scheme

This study examined the challenges of public housing in a democratic Nigeria using the Presidential Mandate Housing Scheme as a case study. Data were derived from purposively selected members of staff of public institutions charged with the responsibility of implementing this scheme in urban areas of Southern Nigeria through interview enquiries and participant observation. These were analyzed using content analysis. The result shows that the scheme was implemented in very few States in Southern part of Nigeria with miniscule number of housing units constructed in those States. Poor programme conception and planning, funding inadequacies and the dearth of preferred building materials were identified as the key challenges that led to the failure of this scheme. The paper argues that despite the return of democratic rule in 1999 and subsequent adoption of the New National Housing and Urban Development Policy in 2002, low organizational capacity of public housing agencies, the lack of collaborations between these agencies and private sector organizations and the none availability of reliable local building materials constitute serious impediments to smooth and successful implementation of public housing programmes in Nigeria. It therefore suggests that the prospects of public housing in democratic Nigeria are contingent upon addressing these challenge

Detection Prospects for Majorana Fermion WIMPless Dark Matter

We consider both velocity-dependent and velocity-independent contributions to spin-dependent (SD) and spin-independent (SI) nuclear scattering (including one-loop corrections) of WIMPless dark matter, in the case where the dark matter candidate is a Majorana fermion. We find that spin-independent scattering arises only from the mixing of exotic squarks, or from velocity-dependent terms. Nevertheless (and contrary to the case of MSSM neutralino WIMPs), we find a class of models which cannot be detected through SI scattering, but can be detected at IceCube/DeepCore through SD scattering. We study the detection prospects for both SI and SD detection strategies for a large range of Majorana fermion WIMPless model parameters.Comment: 14 pages, 3 figures. v2: updated to match published versio

Atmosphere, Interior, and Evolution of the Metal-Rich Transiting Planet HD 149026b

We investigate the atmosphere and interior of the new transiting planet HD 149026b, which appears to be very rich in heavy elements. We first compute model atmospheres at metallicities ranging from solar to ten times solar, and show how for cases with high metallicity or inefficient redistribution of energy from the day side, the planet may develop a hot stratosphere due to absorption of stellar flux by TiO and VO. The spectra predicted by these models are very different than cooler atmosphere models without stratospheres. The spectral effects are potentially detectable with the Spitzer Space Telescope. In addition the models with hot stratospheres lead to a large limb brightening, rather than darkening. We compare the atmosphere of HD 149026b to other well-known transiting planets, including the recently discovered HD 189733b, which we show have planet-to-star flux ratios twice that of HD 209458 and TrES-1. The methane abundance in the atmosphere of HD 189733b is a sensitive indicator of atmospheric temperature and metallicity and can be constrained with Spitzer IRAC observations. We then turn to interior studies of HD 149026b and use a grid of self-consistent model atmospheres and high-pressure equations of state for all components to compute thermal evolution models of the planet. We estimate that the mass of heavy elements within the planet is in the range of 60 to 93 M_earth. Finally, we discuss trends in the radii of transiting planets with metallicity in light of this new member of the class.Comment: Accepted to the Astrophysical Journal. 18 pages, including 10 figures. New section on the atmosphere of planet HD 189733b. Enhanced discussion of atmospheric Ti chemistry and core mass for HD 149026