Putting the Semantics into Semantic Versioning

The long-standing aspiration for software reuse has made astonishing strides in the past few years. Many modern software development ecosystems now come with rich sets of publicly-available components contributed by the community. Downstream developers can leverage these upstream components, boosting their productivity. However, components evolve at their own pace. This imposes obligations on and yields benefits for downstream developers, especially since changes can be breaking, requiring additional downstream work to adapt to. Upgrading too late leaves downstream vulnerable to security issues and missing out on useful improvements; upgrading too early results in excess work. Semantic versioning has been proposed as an elegant mechanism to communicate levels of compatibility, enabling downstream developers to automate dependency upgrades. While it is questionable whether a version number can adequately characterize version compatibility in general, we argue that developers would greatly benefit from tools such as semantic version calculators to help them upgrade safely. The time is now for the research community to develop such tools: large component ecosystems exist and are accessible, component interactions have become observable through automated builds, and recent advances in program analysis make the development of relevant tools feasible. In particular, contracts (both traditional and lightweight) are a promising input to semantic versioning calculators, which can suggest whether an upgrade is likely to be safe.Comment: to be published as Onward! Essays 202

Scale Up This? Improving Scalability and Viability in Upcycling Design

The circular economy (CE) has been hailed as a model for material recirculation, but waste management remains the dominant method of material recovery. Upcycling offers a transitional approach to the CE, reusing waste in ways which increase its value using current recovery systems. However, craft production methods common to the repurposing approach of most upcycling enterprises hinder their ability to scale up. This thesis aims to assist designers in these challenges by informing and improving operational scalability and business viability in upcycling design. Despite its multifold benefits, upcycling practices remain niche. Research on the topic is scattered, and very few publications offer detailed practical guidelines for designers, particularly in furniture and object design, a priority sector for circular initiatives given its heavy waste volumes. To bridge these gaps, this research-creation project employs practice-based, primary and secondary source methods. The author’s design practice in developing a collection of upcycled furniture and objects serves as a real-world example — from material sourcing to design, prototyping and exhibition. This project is later considered in light of two upcycling enterprise case studies as well as a comparative analysis of 20 upcycled furniture and object projects across four categories. This research confirms the challenges of scaling up while identifying numerous practices which can help. These contribute to a proposed strategic design process for upcycling, from material sourcing through to design development. This practical framework aims to support designers and others in creating scalable, viable upcycling projects and enterprises, thus contributing to increased material circularity

Inflammatory Marker Levels among Patients Diagnosed with Autism Spectrum Disorder and Congenital Heart Defects

Autism Spectrum Disorder (ASD) and congenital heart defects (CHD) are conditions that both confer an immense increase in standard of care, and utilization of medical resources addressing comorbidities. One shared symptom that has been consistently cited is inflammation. This review sought to explore the levels of Tumor Necrosis Factor- (TNF-) and Interleukin-6 (IL-6) between patients diagnosed as having either ASD or CHD. By compiling published data containing the mean values of these two inflammatory markers within these populations, it was shown that while both have significantly elevated levels compared to a phenotypically normal demographic, there is no significant difference between IL-6 levels in ASD vs. CHD patients. However, there are significantly higher levels of TNF- in CHD patients compared to ASD patients. Understanding the relationship of inflammatory markers would help guide better treatments and outcomes in ASD population, especially to those with CHD

Berkeley Prosopography Services: Building Research Communities and Restoring Ancient Communities through Digital Tools

Berkeley Prosopography Service (BPS) is an innovative open-source digital tool and service that automatically extracts prosopographic data from TEI-encoded text and generates visualizations of the dynamic social networks contained in the text corpora. Filters allow researchers to vary search parameters to consider alternative or hypothetical scenarios such as the impact of individuals and conditions on social and economic relationships. BPS provides users with individual workspaces for research, assessment and probabilistic modelling, while corpus administrators maintain data integrity. During the grant period, BPS, the first independent tool and service to be incorporated into the international Cuneiform Digital Library consortium, will undergo beta-testing of additional text corpora to confirm the reliability and generalizability of its tools for widespread use in the broad community of prosopographers

ONLINE HEALTH INFORMATION SEEKING BEHAVIOUR: UNDERSTANDING DIFFERENT SEARCH APPROACHES

People intuitively use search engines to look for health information. However, people take an exploratory search approach to find the information in some scenarios, and current search engines do not support these cases well. This exploratory information seeking behaviour is rarely investigated by researchers in the context of online consumer health information. We report on a qualitative study to conceptualise the health information seeking behaviour of lay-people. This paper describes the result of this study, and makes a contribution towards a conceptual understanding of search approaches by people seeking health information, search strategies used by health information seekers, and design implications for providing a better exploratory health search experience

INNOVATION IN DESIGNING HEALTH INFORMATION WEBSITES: RESULTS FROM A QUANTITATIVE STUDY

A wealth of health information exists on the Internet, but successfully finding that information is not easy. One of the issues causing this is the lack of tools for exploring information and assisting in navigation within health websites. As a result, relevant information cannot be easily discovered. We hope to rectify this issue from the design perspective. Based on previous work, we have created a prototype website called Better Health Explorer to better support such information seeking behaviours. This paper reports on a quantitative study evaluating this prototype. The results demonstrate several improvements in health information seeking supported by the tool. Furthermore, we have identified three general design characteristics that should to be considered when designing consumer health websites. These findings have design implications for health information seeking applications, as well as identifying directions for further research

Adverse effects of pegaspargase in pediatric patients receiving doses greater than 3,750 IU

BackgroundIncreased toxicities have been identified with higher doses of pegaspargase (PEG‐ASP) in adults. This has led to routine use of a dose cap of 3,750 IU for adult acute lymphoblastic leukemia (ALL) patients in most institutions. In pediatric ALL patients, PEG‐ASP is not capped. There is concern at our institution that larger doses may result in increased rates of adverse effects and that increased monitoring may be warranted in pediatric patients receiving doses greater than 3,750 IU. The objective of this study is to quantify the difference in the rates of PEG‐ASP‐associated adverse events between pediatric patients who received doses greater than 3,750 IU and less than or equal to 3,750 IU.MethodsRetrospective chart review of patients 1–21 years old with pre‐B‐cell ALL who received PEG‐ASP between 2007 and 2014 at an academic medical center.ResultsOf 183 patients included in the analysis, 24 received PEG‐ASP doses higher than 3,750 IU and 159 received doses less than or equal to 3,750 IU. The incidence of venous thromboembolism (VTE) was significantly higher for patients in the group that received more than 3,750 IU compared with those who received 3,750 IU or less (20.8 vs. 1.89%, respectively; P = 0.0011). The incidence of pancreatitis (P = 0.0306) and hyperglycemia (P = 0.0089) were also higher in the group that received more than 3,750 IU.ConclusionsPEG‐ASP doses higher than 3,750 IU are associated with higher rates of VTE, pancreatitis, and hyperglycemia in pediatric patients with pre‐B‐cell ALL. Patients receiving more than 3,750 IU should have increased monitoring, and larger, multicenter trials are needed to determine if monitoring, VTE prophylaxis, and potential dose capping recommendations should be added to clinical trial protocols.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138220/1/pbc26555_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138220/2/pbc26555.pd

The genetic change in P. falciparum populations of rural Tanzania resulting from national policy on firstline malaria treatment and pilot Sulfadoxine/pyrimethamine and Artesunate combination

Malaria Journal 2010, 9(Suppl 2):P20Theory predicts that we can protect the efficacy of future antimalarials by changing treatment practice or drug formulation, but the potential success of such interventions rests upon their impact on drug pressure in the field. So far, gathering field data on the relationship between policy, drug pressure, recombination and the evolution of resistance has been entirely challenging. To test these predictions, dhfr and dhps frequency changes were measured in two rural districts of Rufiji and Kilombero/Ulanga during 2000-2006, and the frequencies of the two genes compared prior, during and after antimalarial policy change from first line CQ to first line SP in 2001. Furthermore, while SP first line was maintained in Kilombero/Ulanga, pilot combination therapy of SP+Artesunate (ART) was introduced in Rufiji in 2002 to replace SP and dhfr and dhps frequency changes compared between the two districts. Size polymorphisms at three sets of microsatellite loci linked to dhfr and three other sets of unlinked microsatellite loci were analysed. Genetic analysis of SP resistance genes was carried out on 9,662 Plasmodium falciparum infections identified in a series of annual cross sectional surveys conducted in the two districts between 2000-2006. The frequency of dhfr and dhps resistance alleles did not change significantly while SP was the recommended second-line treatment, but highly significant changes occurred during the subsequent year after the switch to first line SP. The frequency of the triple mutant dhfr allele increased by 37% -63% and that of double mutant dhps allele increased 200%-300%. A strong association between these unlinked alleles also emerged; confirming that they are co-selected by SP. Distribution of major lineages indicates that there is extensive genetic exchange among the geographic regions. Combination therapy had visible effect on the frequencies of dhfr and dhps resistance alleles. The findings of this study provide insight on the interplay between policy, drug pressure, recombination and the evolution of resistance

Media, Health Workers, and Policy Makers' Relationship and Their Impact on Antimalarial Policy Adoption: A Population Genetics Perspective

Drug resistance negatively impacts malaria treatments, making treatment policy revision unavoidable. So far, studies relating sociopolitical and technical issues on policy change with malaria parasite genetic change are lacking. We have quantified the effect of malaria treatment policy on drug pressure and the influence of the media, policy makers, and health worker relationship on parasite population genetic change in Kilombro/Ulanga district. Cross-sectional surveys of asymptomatic infections conducted before, during and after the switch from chloroquine to sulphadoxine/pyrimethamine were used for genetic analysis of SP resistance genes in 4,513 asymptomatic infections identified, and their frequency change was compared with retrospective study of the documented process of policy change. Highly significant changes of dhfr and dhps resistance alleles occurred within one year of switch to SP first line, followed by a decline of their rate of selection caused by reduction of SP usage, as a result of negative media reports on SP usage and lack of adequate preparations