Expanded microchannel heat exchanger: design, fabrication and preliminary experimental test

This paper first reviews non-traditional heat exchanger geometry, laser welding, practical issues with microchannel heat exchangers, and high effectiveness heat exchangers. Existing microchannel heat exchangers have low material costs, but high manufacturing costs. This paper presents a new expanded microchannel heat exchanger design and accompanying continuous manufacturing technique for potential low-cost production. Polymer heat exchangers have the potential for high effectiveness. The paper discusses one possible joining method - a new type of laser welding named "forward conduction welding," used to fabricate the prototype. The expanded heat exchanger has the potential to have counter-flow, cross-flow, or parallel-flow configurations, be used for all types of fluids, and be made of polymers, metals, or polymer-ceramic precursors. The cost and ineffectiveness reduction may be an order of magnitude or more, saving a large fraction of primary energy. The measured effectiveness of the prototype with 28 micron thick black low density polyethylene walls and counterflow, water-to-water heat transfer in 2 mm channels was 72%, but multiple low-cost stages could realize the potential of higher effectiveness

Geodynamic setting and origin of the Oman/UAE ophiolite

The ~500km-long mid-Cretaceous Semail nappe of the Sultanate of Oman and UAE (henceforth referred to as the Oman ophiolite) is the largest and best-preserved ophiolite complex known. It is of particular importance because it is generally believed to have an internal structure and composition closely comparable to that of crust formed at the present-day East Pacific Rise (EPR), making it our only known on-land analogue for ocean lithosphere formed at a fast spreading rate. On the basis of this assumption Oman has long played a pivotal role in guiding our conceptual understanding of fast-spreading ridge processes, as modern fast-spread ocean crust is largely inaccessible

Anti-parasitic benzoxaboroles are ineffective against Theileria parva in vitro

East Coast Fever (ECF) is a disease affecting cattle in sub-Saharan Africa, caused by the tick-borne Apicomplexan pathogen Theileria parva. The disease is a major problem for cattle farmers in affected regions and there are few methods of control, including a complex infection and treatment vaccine, expensive chemotherapy, and the more widespread tick control through acaricides. New intervention strategies are, therefore, sorely needed. Benzoxaboroles are a versatile class of boron-heterocyclic compounds with demonstrable pharmacological activity against a diverse group of pathogens, including those related to T. parva. In this study, the in vitro efficacy of three benzoxaboroles against the intracellular schizont stage of T. parva was investigated using a flow cytometry approach. Of the benzoxaboroles tested, only one showed any potency, albeit only at high concentrations, even though there is high protein sequence similarity in the CPSF3 protein target compared to other protozoan pathogen species. This finding suggests that benzoxaboroles currently of interest for the treatment of African animal trypanosomiasis, toxoplasmosis, cryptosporidiosis and malaria may not be suitable for the treatment of ECF. We conclude that testing of further benzoxaborole compounds is needed to fully determine whether any lead compounds can be identified to target T. parva

The Metallicity of Pre-Galactic Globular Clusters: Observational consequences of the first stars

We explore a scenario where metal-poor globular clusters (GCs) are enriched by the first supernovae in the Universe. If the first stars in a 10^7 Msun dark halo were very massive (>180 Msun), then a pair instability supernova from a single massive star can produce sufficient iron to enrich 10^6 Msun of pristine, primordial gas to [Fe/H] ~ -2. In such a scenario, where a single massive star acts as a seed for halo GCs, the accurate abundance analysis of GC stars would allow a direct measurement of the Population III initial mass. Using the latest theoretical yields for zero metallicity stars in the mass range 140-260 Msun, we find that the metals expelled from a ~230 Msun star are consistent with [Si/Fe] and [Ca/Fe] observed in GC stars. However, no single star in this mass range can simultaneously explain all halo GC heavy-element abundance ratios, such as [V/Fe], [Ti/Fe] and [Ni/Fe]. These require a combination masses for the Population III stellar progenitors. The various observational consequences of this scenario are discussed.Comment: 5 pages, 2 figures, accepted for publication in ApJ Lette

Research on the Human Dimensions of Climate Change in Nunavut, Nunavik, and Nunatsiavut: A Literature Review and Gap Analysis

Research on the human dimensions of climate change (HDCC) in the Canadian Arctic has expanded so rapidly over the past decade that we do not have a clear grasp of the current state of knowledge or research gaps. This lack of clarity has implications for duplication of climate policy and research, and it has been identified as a problem by communities, scientists, policy makers, and northern organizations. Our review of current knowledge about the HDCC in Nunavut, Nunavik, and Nunatsiavut indicates that the effects of climate change on subsistence harvesting and other land-based activities and the determinants of vulnerability and adaptation to such changes are well understood. However, the effects of climate change on health are less known. In the nascent research on this topic, studies on food security and personal safety dominate, and little peer-reviewed scholarship focuses on the business and economic sector. Published research shows a strong bias toward case studies in smaller communities, especially communities in Nunavut. Such studies have focused primarily on negative impacts of climate change, present-day vulnerabilities, and adaptive capacity, but studies proposing opportunities for adaptation intervention are beginning to emerge. While documenting the serious risks posed by climate change, they also highlight the adaptability of northern populations and the effects of economic-political stresses on vulnerability to changing climate. We note the absence of studies that examine how Northerners can benefit from new opportunities that may arise from climate change, or assess how the interaction of future climatic and socio-economic changes (specifically, resource development and enhanced shipping) will affect their experience of and response to climate change, or discuss the broader determinants of vulnerability and adaptation.L’étude des dimensions humaines du changement climatique (DHCC) dans l’Arctique canadien a pris de l’ampleur ces dix dernières années au point où nous n’avons pas une idée claire de l’état actuel des connaissances ou des lacunes en matière de recherche. Cette absence de précision a des incidences sur le plan du dédoublement des politiques et des études sur le climat, ce qui est considéré comme problématique par les collectivités, les scientifiques, les décisionnaires et les organi­sations se trouvant dans le Nord. Nous avons passé en revue les connaissances actuelles en matière de DHCC au Nunavut, au Nunavik et au Nunatsiavut, ce qui nous a permis de constater que les effets du changement climatique sur les récoltes de subsistance et sur d’autres activités rattachées aux ressources naturelles sont bien compris, tout comme le sont les déterminants de la vulnérabilité et de l’adaptation à ces changements. Cela dit, les effets du changement climatique sur la santé sont moins bien connus. Dans le cadre des recherches à l’état naissant à ce sujet, les études portant sur l’innocuité alimentaire et la sécurité personnelle dominent, et peu d’études évaluées par les pairs sont axées sur le secteur commercial et économique. Les travaux de recherche dont les résultats ont été publiés indiquent un fort penchant pour des études de cas visant de plus petites collectivités, surtout les collectivités du Nunavut. Ces études portent principalement sur les incidences négatives du changement climatique, sur les vulnérabilités actuelles et sur la capacité d’adaptation, quoi que des études proposant des possibilités d’intervention adaptative commencent à faire surface. Bien que des études se trouvent à documenter les risques sérieux que pose le changement climatique, elles font également ressortir l’adaptabilité des populations nordiques et les effets des stress politiques et économiques sur la vulnérabilité au climat changeant. Nous avons aussi remarqué l’absence d’études qui examinent comment les gens du Nord peuvent bénéficier des retombées du changement climatique, d’études qui évaluent comment l’interaction des changements climatiques et socioéconomiques futurs (plus précisément en ce qui a trait à la mise en valeur des ressources et à l’amélioration des voies d’expédition) toucheront leur expérience du changement climatique et leur réaction à celui-ci, ou d’études qui discutent des plus grands déterminants de la vulnérabilité et de l’adaptation

A monument to the player: Preserving a landscape of socio-cultural capital in the transitional MMORPG

This is the pre-print version of the Article. The official published version can be accessed from the links below - Copyright @ 2012 Taylor & Francis LtdMassively multiplayer online role-playing games (MMORPGs) produce dynamic socio-ludic worlds that nurture both culture and gameplay to shape experiences. Despite the persistent nature of these games, however, the virtual spaces that anchor these worlds may not always be able to exist in perpetuity. Encouraging a community to migrate from one space to another is a challenge now facing some game developers. This paper examines the case of Guild Wars® and its “Hall of Monuments”, a feature that bridges the accomplishments of players from the current game to the forthcoming sequel. Two factor analyses describe the perspectives of 105 and 187 self-selected participants. The results reveal four factors affecting attitudes towards the feature, but they do not strongly correlate with existing motivational frameworks, and significant differences were found between different cultures within the game. This informs a discussion about the implications and facilitation of such transitions, investigating themes of capital, value perception and assumptive worlds. It is concluded that the way subcultures produce meaning needs to be considered when attempting to preserve the socio-cultural landscape

E. coli O157 on Scottish cattle farms: evidence of local spread and persistence using repeat cross-sectional data

<b>Background</b><p></p> Escherichia coli (E. coli) O157 is a virulent zoonotic strain of enterohaemorrhagic E. coli. In Scotland (1998-2008) the annual reported rate of human infection is 4.4 per 100,000 population which is consistently higher than other regions of the UK and abroad. Cattle are the primary reservoir. Thus understanding infection dynamics in cattle is paramount to reducing human infections.<p></p> A large database was created for farms sampled in two cross-sectional surveys carried out in Scotland (1998 - 2004). A statistical model was generated to identify risk factors for the presence of E. coli O157 on farms. Specific hypotheses were tested regarding the presence of E. coli O157 on local farms and the farms previous status. Pulsed-field gel electrophoresis (PFGE) profiles were further examined to ascertain whether local spread or persistence of strains could be inferred.<p></p> <b>Results</b><p></p> The presence of an E. coli O157 positive local farm (average distance: 5.96km) in the Highlands, North East and South West, farm size and the number of cattle moved onto the farm 8 weeks prior to sampling were significant risk factors for the presence of E. coli O157 on farms. Previous status of a farm was not a significant predictor of current status (p = 0.398). Farms within the same sampling cluster were significantly more likely to be the same PFGE type (p < 0.001), implicating spread of strains between local farms. Isolates with identical PFGE types were observed to persist across the two surveys, including 3 that were identified on the same farm, suggesting an environmental reservoir. PFGE types that were persistent were more likely to have been observed in human clinical infections in Scotland (p < 0.001) from the same time frame.<p></p> <b>Conclusions</b><p></p> The results of this study demonstrate the spread of E. coli O157 between local farms and highlight the potential link between persistent cattle strains and human clinical infections in Scotland. This novel insight into the epidemiology of Scottish E. coli O157 paves the way for future research into the mechanisms of transmission which should help with the design of control measures to reduce E. coli O157 from livestock-related sources

Differential effects of apolipoprotein E isoforms on phosphorylation at specific sites on tau by glycogen synthase kinase-3β identified by nano-electrospray mass spectrometry

AbstractPreviously published data have shown an allele-specific variation in the in vitro binding of apolipoprotein E (apoE) to tau, which prompted the hypothesis that apoE binding may protect tau from phosphorylation, apoE3 being more efficient than apoE4. We have, therefore, investigated the effects of apoE on tau phosphorylation in vitro by the proline-directed kinase, glycogen synthase kinase (GSK)-3β. The phosphopeptide maps of tau alone, of tau with apoE3 and of tau with apoE4 were very similar. When apoE2 was present a further four spots were evident. Additionally, of the 15 peptides phosphorylated in the presence or absence of apoE, subtle differences, some isoform-specific, in the relative amounts of phosphorylation were observed

Analysis of polymorphisms in the merozoite surface protein-3α gene and two microsatellite loci in Sri Lankan Plasmodium vivax: evidence of population substructure in Sri Lanka.

The geographical distribution of genetic variation in Plasmodium vivax samples (N = 386) from nine districts across Sri Lanka is described using three markers; the P. vivax merozoite surface protein-3α (Pvmsp-3α) gene, and the two microsatellites m1501 and m3502. At Pvmsp-3α, 11 alleles were found with an expected heterozygosity (H(e)) of 0.81, whereas at m1501 and m3502, 24 alleles (H(e) = 0.85) and 8 alleles (H(e) = 0.74) were detected, respectively. Overall, 95 unique three locus genotypes were detected among the 279 samples positive at all three loci (H(e) = 0.95). Calculating the pairwise fixation index (F(ST)) revealed statistically significant population structure. The presence of identical 2-loci microsatellite genotypes in a significant proportion of samples revealed local clusters of closely related isolates contributing to strong linkage disequilibrium between marker alleles. The results show evidence of high genetic diversity and possible population substructure of P. vivax populations in Sri Lanka