Labor-Management Cooperation on Teaching and Learning Cleveland Municipal School District

The Cleveland Municipal School District and the Cleveland Teachers Union have established a collaborative relationship that has enabled them to work jointly on a number of innovative programs designed to improve teaching and learning in the schools of Cleveland. The educational standards set forth in Educating Cleveland’s Children are the foundation for much of this work. The challenges now facing the District and the CTU are to keep track of all these programs, assess their effectiveness with respect to teaching and learning, and ensure that the changes in organizational culture necessary to support this work are realized in each school. The breadth and depth of change to which the parties have committed demands a tremendous investment of time, money, and energy. As CTU President Richard DeColibus noted, such a vast undertaking will require resources beyond what the Union and the District can contribute. It is fortunate that in Cleveland the schools have the support not only of the city administration, but also of parents, civic and business leaders, foundations, social service agencies, and other city employees. If the District and the Union can continue to engage these other entities, it seems likely they will be able to create a high-functioning learning community that is uniquely equipped to meet the needs of all of Cleveland's children

Massachusetts Education Partnership: Policy, Leadership, Labor-Management Collaboration

The Massachusetts Education Partnership (MEP) is a collaborative endeavor on the part of four education-related organizations representing teachers, superintendents, and school committees and four research institutions. By working together, the Partnership aims to improve student achievement through labor-management collaboration and to foster the development of collaborative cultures in Massachusetts school districts. As of March 1, 2014, the MEP has trained labor and management leaders from 34 school districts in interest-based bargaining (IBB) and provided intensive facilitation to seven school districts where labor and management are working collaboratively on a program or issue of their choosing

Militarization and social development in the Third World

In this study we integrated the modernization and dependency theories of development to suggest the ways whereby militarization can affect development. We examined the effects of three components of militarization highlighted in these theories on the social development of ninety-two developing countries. Overall, our findings support the dependency theory's emphasis on the detrimental impact of international trade on disadvantaged nations. There is a significant negative correlation between arms import and social development. Arms export and indigenous spending are correlated with social development in the expected directions but their beta coefficients are not significant. The diverse ways these three aspects of militarization have been shown to affect social development help to explain some of the conflicting findings in the literature and point to the need to study these variables in their disaggregated form.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69141/2/10.1177_144078339503100105.pd

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

Archives & Manuscripts: Exhibits (Book Review)

published or submitted for publicatio

J. Franklin Jameson and the Birth of the National Archives (Book Review)

published or submitted for publicatio

Labor-Management Cooperation on Teaching and Learning Cleveland Municipal School District

The Cleveland Municipal School District and the Cleveland Teachers Union have established a collaborative relationship that has enabled them to work jointly on a number of innovative programs designed to improve teaching and learning in the schools of Cleveland. The educational standards set forth in Educating Cleveland€ٳ Children are the foundation for much of this work. The challenges now facing the District and the CTU are to keep track of all these programs, assess their effectiveness with respect to teaching and learning, and ensure that the changes in organizational culture necessary to support this work are realized in each school. The breadth and depth of change to which the parties have committed demands a tremendous investment of time, money, and energy. As CTU President Richard DeColibus noted, such a vast undertaking will require resources beyond what the Union and the District can contribute. It is fortunate that in Cleveland the schools have the support not only of the city administration, but also of parents, civic and business leaders, foundations, social service agencies, and other city employees. If the District and the Union can continue to engage these other entities, it seems likely they will be able to create a high-functioning learning community that is uniquely equipped to meet the needs of all of Cleveland's children.Labor-Management Cooperation,