Comparative Analysis Of The New Guidelines And Consensuses For The Management Of Hypothyroidism, Thyroid Nodules, And Differentiated Thyroid Cancer [análise Comparativa Das Novas Diretrizes E Consensos Para O Manejo Do Hipotireoidismo, Nódulos Tireoidianos E Câncer Diferenciado De Tireoide]

[No abstract available]574233239Rosário, P., Ward, L., Carvalho, G., Graf, H., Maciel, R., McIel, L., Thyroid nodule and differentiated thyroid cancer: Update on the Brazilian consensus (2013) Arq Bras Endocrinol Metab.Maia, A.L., Ward, L.S., Carvalho, G.A., Graf, H., Maciel, R.M., McIel, L.M., Thyroid nodules and differentiated thyroid cancer: Brazilian consensus (2007) Arq Bras Endocrinol Metabol., 51 (5), pp. 867-893Graf, H., Sgarbi, J., Vaisman, M., Bergoglio, L., Brenta, G., Orlandi, A., Clinical practice guideline for the management of hypothyroidism (2013) Arq Bras Endocrinol Metab.Garber, J.R., Cobin, R.H., Gharib, H., Hennessey, J.V., Klein, I., Mechanick, J.I., Clinical practice guidelines for hypothyroidism in adults: Co-sponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association (2013) Thyroid., 22 (12), pp. 1200-1235Carvalho, G., Perez, C., Ward, L., The clinical use of thyroid function tests (2013) Arq Bras Endocrinol Metab., 57 (3), pp. 193-204Brent, G.A., The debate over thyroid-function screening in pregnancy (2012) N Engl J Med, 366 (6), pp. 562-563Ladenson, P.W., Singer, P.A., Ain, K.B., Bagchi, N., Bigos, S.T., Levy, E.G., American Thyroid Association guidelines for detection of thyroid dysfunction (2000) Arch Intern Med., 160 (11), pp. 1573-1575Hyland, K.A., Arnold, A.M., Lee, J.S., Cappola, A.R., Persistent subclinical hypothyroidism and cardiovascular risk in the elderly: The cardiovascular health study (2013) J Clin Endocrinol Metab., 98 (2), pp. 533-540Sgarbi, J., Teixeira, P., McIel, L., Mazeto, G., Vaisman, M., Montenegro Jr., R., The Brazilian consensus for the clinical approach and treatment of subclinical hypothyroidism in adults: Recommendations of the thyroid Department of the Brazilian Society of Endocrinology and Metabolism (2013) Arq Bras Endocrinol Metab.Wiersinga, W.M., Duntas, L., Fadeyev, V., Nygaard, B., Vanderpump, M.P.J., 2012 ETA Guidelines: The Use of L-T4 + L-T3 in the Treatment of Hypothyroidism (2012) Eur Thyroid J., 1, pp. 55-71Cooper, D.S., Doherty, G.M., Haugen, B.R., Kloos, R.T., Lee, S.L., Mandel, S.J., Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer (2009) Thyroid., 19 (11), pp. 1167-1214Can, A.S., Peker, K., Comparison of palpation-versus ultrasoundguided fine-needle aspiration biopsies in the evaluation of thyroid nodules (2008) BMC Res Notes., 1, p. 12Cesur, M., Corapcioglu, D., Bulut, S., Gursoy, A., Yilmaz, A.E., Erdogan, N., Comparison of palpation-guided fine-needle aspiration biopsy to ultrasound-guided fine-needle aspiration biopsy in the evaluation of thyroid nodules (2006) Thyroid., 16 (6), pp. 555-561Izquierdo, R., Arekat, M.R., Knudson, P.E., Kartun, K.F., Khurana, K., Kort, K., Comparison of palpation-guided versus ultrasound-guided fine-needle aspiration biopsies of thyroid nodules in an outpatient endocrinology practice (2006) Endocr Pract., 12 (6), pp. 609-614Cerutti, J.M., Nodule diagnosed as follicular patterned lesion: Are biomarkers the promise? (2007) Arq Bras Endocrinol Metabol., 51 (5), pp. 832-842Ward, L.S., Kloos, R.T., Molecular markers in the diagnosis of thyroid nodules (2013) Arq Bras Endocrinol Metabol., 57 (2), pp. 89-97Schlumberger, M., Catargi, B., Borget, I., Deandreis, D., Zerdoud, S., Bridji, B., Strategies of radioiodine ablation in patients with low-risk thyroid cancer (2012) N Engl J Med., 366 (18), pp. 1663-1673Sawka, A.M., Iodine radioisotope diagnostic scanning with SPECT/ CT after thyroidectomy for thyroid cancer: Essential data or unnecessary investigation? (2013) J Clin Endocrinol Metab., 98 (3), pp. 958-96

Radioiodine plus recombinant human thyrotropin do not cause acute airway compression and are effective in reducing multinodular goiter

Recombinant human thyrotropin (rhTSH) reduces the activity of radioiodine required to treat multinodular goiter (MNG), but acute airway compression can be a life-threatening complication. In this prospective, randomized, double-blind, placebo-controlled study, we assessed the efficacy and safety (including airway compression) of different doses of rhTSH associated with a fixed activity of 131I for treating MNG. Euthyroid patients with MNG (69.3 ± 62.0 mL, 20 females, 2 males, 64 ± 7 years) received 0.1 mg (group I, N = 8) or 0.01 mg (group II, N = 6) rhTSH or placebo (group III, N = 8), 24 h before 1.11 GBq 131I. Radioactive iodine uptake was determined at baseline and 24 h after rhTSH and thyroid volume (TV, baseline and 6 and 12 months after treatment) and tracheal cross-sectional area (TCA, baseline and 2, 7, 180, and 360 days after rhTSH) were determined by magnetic resonance; antithyroid antibodies and thyroid hormones were determined at frequent intervals. After 6 months, TV decreased significantly in groups I (28.5 ± 17.6%) and II (21.6 ± 17.8%), but not in group III (2.7 ± 15.3%). After 12 months, TV decreased significantly in groups I (36.7 ± 18.1%) and II (37.4 ± 27.1%), but not in group III (19.0 ± 24.3%). No significant changes in TCA were observed. T3 and free T4 increased transiently during the first month. After 12 months, 7 patients were hypothyroid (N = 3 in group I and N = 2 in groups II and III). rhTSH plus a 1.11-GBq fixed 131I activity did not cause acute or chronic changes in TCA. After 6 and 12 months, TV reduction was more pronounced among patients treated with rhTSH plus 131I

Whole exome sequencing of extreme morbid obesity patients: translational implications for obesity and related disorders

Whole-exome sequencing (WES) is a new tool that allows the rapid, inexpensive and accurate exploration of Mendelian and complex diseases, such as obesity. To identify sequence variants associated with obesity, we performed WES of family trios of one male teenager and one female child with severe early-onset obesity. Additionally, the teenager patient had hypopituitarism and hyperprolactinaemia. A comprehensive bioinformatics analysis found de novo and compound heterozygote sequence variants with a damaging effect on genes previously associated with obesity in mice (LRP2) and humans (UCP2), among other intriguing mutations affecting ciliary function (DNAAF1). A gene ontology and pathway analysis of genes harbouring mutations resulted in the significant identification of overrepresented pathways related to ATP/ITP (adenosine/inosine triphosphate) metabolism and, in general, to the regulation of lipid metabolism. We discuss the clinical and physiological consequences of these mutations and the importance of these findings for either the clinical assessment or eventual treatment of morbid obesity.Gilberto Paz-Filho, Margaret C.S. Boguszewski, Claudio A. Mastronardi, Hardip R. Patel, Angad S. Johar, Aaron Chuah, Gavin A. Huttley, Cesar L. Boguszewski, Ma-Li Wong, Mauricio Arcos-Burgos and Julio Licini

Criação de variedades de citros mediante o desenvolvimento de linhagens homozigotas a partir da obtenção de haploides.

O melhoramento convencional em citros é tido como uma técnica lenta e cara, podendo levar de 25 a 30 anos para um lançamento de uma nova variedade. Visando agilizá-lo, existem diversas técnicas biotecnológicas, dentre elas a androgênese, que consiste na obtenção de haploides mediante a cultura in vitro de anteras

Nonlinear vortex light beams supported and stabilized by dissipation

We describe nonlinear Bessel vortex beams as localized and stationary solutions with embedded vorticity to the nonlinear Schr\"odinger equation with a dissipative term that accounts for the multi-photon absorption processes taking place at high enough powers in common optical media. In these beams, power and orbital angular momentum are permanently transferred to matter in the inner, nonlinear rings, at the same time that they are refueled by spiral inward currents of energy and angular momentum coming from the outer linear rings, acting as an intrinsic reservoir. Unlike vortex solitons and dissipative vortex solitons, the existence of these vortex beams does not critically depend on the precise form of the dispersive nonlinearities, as Kerr self-focusing or self-defocusing, and do not require a balancing gain. They have been shown to play a prominent role in "tubular" filamentation experiments with powerful, vortex-carrying Bessel beams, where they act as attractors in the beam propagation dynamics. Nonlinear Bessel vortex beams provide indeed a new solution to the problem of the stable propagation of ring-shaped vortex light beams in homogeneous self-focusing Kerr media. A stability analysis demonstrates that there exist nonlinear Bessel vortex beams with single or multiple vorticity that are stable against azimuthal breakup and collapse, and that the mechanism that renders these vortexes stable is dissipation. The stability properties of nonlinear Bessel vortex beams explain the experimental observations in the tubular filamentation experiments.Comment: Chapter of boo

Seleção de porta-enxertos de citros mediante desenvolvimento do sistema radicular com ênfase na tolerância à seca

Desenvolvimento de Variedade