The gender and access to health services study: final report

Men and women frequently think and behave differently. To observe this is not to suggest anything so absurdly simple as that there are only male and female ways of being; behaviours and thought processes vary according to numerous other factors besides gender. That this is very generally the case however, does mean that there are broad - and often broadly predictable - differences in the way men and women engage with the world. Most commercial organisations understand this very well and plan accordingly. Many public authorities recognise it too and take these differences into account when developing and providing services. For historical reasons however the NHS has rarely done so. It is widely known that there are differences between men and women in the incidence and prevalence of most health conditions. Sometimes there are clear biological reasons for these differences but often there are not. Where biology offers little or no enlightenment, other questions need to be asked: · Do men and women behave in ways that predispose them to particular health conditions to different degrees? · Do men and women use health services with different degrees of effectiveness? · Do men and women receive differerent kinds of service from the NHS? The answer is – yes, these things happen frequently. This is sometimes to the disadvantage of one sex and sometimes to the disadvantage of the other. Sometimes it is to the disadvantage of both. And when these things happen, health outcomes are often affected. This report looks at the reasons why gender is such an important and fundamental determinant of health status and considers the ways in which gender inequalities can be tackled within the present legislative and policy framework. It also brings together the knowledge and evidence in relation to six specific areas of health concerns

Development and fabrication of radiation resistant high efficiency solar cells Final periodic report, 24 Aug. 1966 - 24 Feb. 1967

Diffusion process for lithium doping of solar cells, and electrical characteristics and radiation resistance of solar cell

Segmental aging underlies the development of a Parkinson phenotype in the AS/AGU rat

There is a paucity of information on the molecular biology of aging processes in the brain. We have used biomarkers of aging (SA β-Gal, p16Ink4a, Sirt5, Sirt6, and Sirt7) to demonstrate the presence of an accelerated aging phenotype across different brain regions in the AS/AGU rat, a spontaneous Parkinsonian mutant of PKCγ derived from a parental AS strain. P16INK4a expression was significantly higher in AS/AGU animals compared to age-matched AS controls (p < 0.001) and displayed segmental expression across various brain regions. The age-related expression of sirtuins similarly showed differences between strains and between brain regions. Our data clearly show segmental aging processes within the rat brain, and that these are accelerated in the AS/AGU mutant. The accelerated aging, Parkinsonian phenotype, and disruption to dopamine signalling in the basal ganglia in AS/AGU rats, suggests that this rat strain represents a useful model for studies of development and progression of Parkinson's disease in the context of biological aging and may offer unique mechanistic insights into the biology of aging

Study of state-of-the-art static inverter design Final report, 6 Jan. - 6 Jun. 1966

Multiple purpose inverter design based on phase demodulated inverter circuit selected from state-of-the-art assessment of ten inverter circuit

Characterization of the IFN-γ T-cell responses to immediate early antigens in humans with genital herpes

BACKGROUND: The IFN-γ ELISPOT assay has been used to examine the T-cell repertoire for many disease states in humans but, as yet, not genital herpes. Using overlapping synthetic peptide libraries, an IFN-γ ELISPOT assay was established that could measure CD4 and CD8 T-cell responses to HSV-2 antigens in patients with genital herpes. RESULTS: In unexpanded T-cells isolated from peripheral blood, CD4 responses were readily measured against four immediate early antigens (ICP0, ICP4, ICP22 and ICP27), VP22 and gD. The CD4 responses were characterized by a low number of positive cells which produced large ELISPOTs. CD4 responses had a broad specificity and within individual patients several of the test antigens were recognized. In contrast, CD8 responses were found only in approximately 50% of patients and were typically specific to a single antigen. When disease status and immune responses were compared, an enhanced CD4 response to ICP4 in patients with a low recurrence rate was found. The ICP4 response was striking in three HSV-1 single positive genital herpes patients. CONCLUSION: The survey of T-cell responses is an important step to understand the host cellular immune response in individuals with genital herpes. The assay described here has the capability of measuring CD4 and CD8 T-cell responses that may be used to correlate disease status with specific immune responses. In an evaluation of 18 subjects a trend of positive responses to an immediate early protein, ICP4, was found in individuals that had a low rate of disease recurrence

Shell-model calculations for the three-nucleon system

We use Faddeev's decomposition to solve the shell-model problem for three nucleons. The dependence on harmonic-oscillator excitations allowed in the model space, up to $32 \hbar\Omega$ in the present calculations, and on the harmonic-oscillator frequency is studied. Effective interactions derived from Nijmegen II and Reid93 potentials are used in the calculations. The binding energies obtained are close to those calculated by other methods. The structure of the Faddeev equations is discussed and a simple formula for matrix elements of the permutation operators in a harmonic-oscillator basis is given. The Pauli principle is properly treated in the calculations.Comment: 11 pages. REVTEX. 6 PostScript figure

An inventory and condition survey of rangelands in the Carnarvon Basin, Western Australia

The inventory and condition survey of rangelands in the Carnarvon Basin, undertaken by the Department of Agriculture and Food, Western Australia (DAFWA) between 1980 and 1982, describes and maps the natural resources of the region’s pastoral leasehold land. This survey report provides a baseline record of the existence and condition of the natural area’s resources, to assist with the planning and implementation of land management practices. The report identified and described the condition of soils, landforms, vegetation, habitat, ecosystems, and declared plants and animals. It also assessed the impact of pastoralism and made land management recommendations. The area surveyed covers about 74 500km² in the Carnarvon Basin and Shark Bay regions, and includes the catchments of the Lyndon and Minilya rivers and the lower reaches of the Gascoyne and Wooramel Rivers. The vegetation of the Carnarvon Basin area is mainly dominated by perennial shrubs. A small number of botanical families contain a large proportion of the dominant perennials in the area. Of these Acacia, Eremophila and Cassia are pre-eminent in the taller shrub communities, Atriplex and Maireana in the low chenopod shrublands, Eucalyptus in the low woodlands and Triodia and Plectrachne in the hummock grasslands

Ensemble density-functional theory for ab-initio molecular dynamics of metals and finite-temperature insulators

A new method is presented for performing first-principles molecular-dynamics simulations of systems with variable occupancies. We adopt a matrix representation for the one-particle statistical operator Gamma, to introduce a ``projected'' free energy functional G that depends on the Kohn-Sham orbitals only and that is invariant under their unitary transformations. The Liouville equation [ Gamma , H ] = 0 is always satisfied, guaranteeing a very efficient and stable variational minimization algorithm that can be extended to non-conventional entropic formulations or fictitious thermal distributions.Comment: 5 pages, two-column style with 2 postscript figures embedded. Uses REVTEX and epsf macros. Also available at http://www.physics.rutgers.edu/~dhv/preprints/index.html#nm_meta