3,646 research outputs found
Analysis of the Brinkman-Forchheimer equations with slip boundary conditions
In this work, we study the Brinkman-Forchheimer equations driven under slip
boundary conditions of friction type. We prove the existence and uniqueness of
weak solutions by means of regularization combined with the Faedo-Galerkin
approach. Next we discuss the continuity of the solution with respect to
Brinkman's and Forchheimer's coefficients. Finally, we show that the weak
solution of the corresponding stationary problem is stable
Ab initio diffusional potential energy surface for CO chemisorption on Pd{110} at high coverage: Coupled translation and rotation
[[abstract]]The ground statepotential energy surface for CO chemisorption across Pd{110} has been calculated using density functional theory with gradient corrections at monolayer coverage. The most stable site corresponds well with the experimental adsorption heat, and it is found that the strength of binding to sites is in the following order: pseudo-short-bridge>atop>long-bridge>hollow. Pathways and transition states for CO surfacediffusion, involving a correlation between translation and orientation, are proposed and discussed.[[notice]]補正完畢[[journaltype]]國外[[booktype]]紙本[[countrycodes]]US
Development and validation of the Cambridge Multimorbidity Score
BACKGROUND: Health services have failed to respond to the pressures of multimorbidity. Improved measures of multimorbidity are needed for conducting research, planning services and allocating resources. METHODS: We modelled the association between 37 morbidities and 3 key outcomes (primary care consultations, unplanned hospital admission, death) at 1 and 5 years. We extracted development (n = 300 000) and validation (n = 150 000) samples from the UK Clinical Practice Research Datalink. We constructed a general-outcome multimorbidity score by averaging the standardized weights of the separate outcome scores. We compared performance with the Charlson Comorbidity Index. RESULTS: Models that included all 37 conditions were acceptable predictors of general practitioner consultations (C-index 0.732, 95% confidence interval [CI] 0.731-0.734), unplanned hospital admission (C-index 0.742, 95% CI 0.737-0.747) and death at 1 year (C-index 0.912, 95% CI 0.905-0.918). Models reduced to the 20 conditions with the greatest combined prevalence/weight showed similar predictive ability (C-indices 0.727, 95% CI 0.725-0.728; 0.738, 95% CI 0.732-0.743; and 0.910, 95% CI 0.904-0.917, respectively). They also predicted 5-year outcomes similarly for consultations and death (C-indices 0.735, 95% CI 0.734-0.736, and 0.889, 95% CI 0.885-0.892, respectively) but performed less well for admissions (C-index 0.708, 95% CI 0.705-0.712). The performance of the general-outcome score was similar to that of the outcome-specific models. These models performed significantly better than those based on the Charlson Comorbidity Index for consultations (C-index 0.691, 95% CI 0.690-0.693) and admissions (C-index 0.703, 95% CI 0.697-0.709) and similarly for mortality (C-index 0.907, 95% CI 0.900-0.914). INTERPRETATION: The Cambridge Multimorbidity Score is robust and can be either tailored or not tailored to specific health outcomes. It will be valuable to those planning clinical services, policymakers allocating resources and researchers seeking to account for the effect of multimorbidity
Feedback Stabilization of a Class of Diagonal Infinite-Dimensional Systems with Delay Boundary Control
This paper studies the boundary feedback stabilization of a class of diagonal
infinite-dimensional boundary control systems. In the studied setting, the
boundary control input is subject to a constant delay while the open loop
system might exhibit a finite number of unstable modes. The proposed control
design strategy consists in two main steps. First, a finite-dimensional
subsystem is obtained by truncation of the original Infinite-Dimensional System
(IDS) via modal decomposition. It includes the unstable components of the
infinite-dimensional system and allows the design of a finite-dimensional delay
controller by means of the Artstein transformation and the pole-shifting
theorem. Second, it is shown via the selection of an adequate Lyapunov function
that 1) the finite-dimensional delay controller successfully stabilizes the
original infinite-dimensional system; 2) the closed-loop system is
exponentially Input-to-State Stable (ISS) with respect to distributed
disturbances. Finally, the obtained ISS property is used to derive a small gain
condition ensuring the stability of an IDS-ODE interconnection.Comment: Preprin
The Star Formation History of the Large Magellanic Cloud
We present the first-ever global, spatially-resolved reconstruction of the
star formation history (SFH) of the Large Magellanic Cloud (LMC), based on the
application of our StarFISH analysis software to the multiband photometry of
twenty million of its stars from the Magellanic Clouds Photometric Survey. The
general outlines of our results are consistent with previously published
results: following an initial burst of star formation, there was a quiescent
epoch from approximately 12 to 5 Gyr ago. Star formation then resumed and has
proceeded until the current time at an average rate of roughly 0.2 solar
masses/yr, with temporal variations at the factor-of-two level. The re-ignition
of star formation about 5 Gyr ago, in both the LMC and SMC, is suggestive of a
dramatic event at that time in the Magellanic system. Among the global
variations in the recent star formation rate are peaks at roughly 2 Gyr, 500
Myr, 100 Myr and 12 Myr. The peaks at 500 Myr and 2 Gyr are nearly coincident
with similar peaks in the SFH of the Small Magellanic Cloud, suggesting a joint
history for these galaxies extending back at least several Gyr. The chemical
enrichment history recovered from our StarFISH analysis is in broad agreement
with that inferred from the LMC's star cluster population, although our
constraints on the ancient chemical enrichment history are weak. We conclude
from the concordance between the star formation and chemical enrichment
histories of the field and cluster populations that the field and cluster star
formation modes are tightly coupled.Comment: 20 pages, with color figures. Accepted for publication in A
Toward harmonization of clinical molecular diagnostic reports: findings of an international survey
Toward harmonization of clinical molecular diagnostic reports: findings of an international survey
Association of comorbidity and health service usage among patients with dementia in the UK: a population-based study
: The majority of people with dementia have other long-term diseases, the presence of which may affect the progression and management of dementia. This study aimed to identify subgroups with higher healthcare needs, by analysing how primary care consultations, number of prescriptions and hospital admissions by people with dementia varies with having additional long-term diseases (comorbidity).
: A retrospective cohort study based on health data from the Clinical Practice Research Datalink (CPRD) was conducted. Incident cases of dementia diagnosed in the year starting 1/3/2008 were selected and followed for up to 5 years. The number of comorbidities was obtained from a set of 34 chronic health conditions. Service usage (primary care consultations, hospitalisations and prescriptions) and time-to-death were determined during follow-up. Multilevel negative binomial regression and Cox regression, adjusted for age and gender, were used to model differences in service usage and death between differing numbers of comorbidities.
: Data from 4999 people (14 866 person-years of follow-up) were analysed. Overall, 91.7% of people had 1 or more additional comorbidities. Compared with those with 2 or 3 comorbidities, people with ≥6 comorbidities had higher rates of primary care consultations (rate ratio (RR) 1.31, 95% CI 1.25 to 1.36), prescriptions (RR 1.68, 95% CI 1.57 to 1.81), and hospitalisation (RR 1.62, 95% CI 1.44 to 1.83), and higher risk of death (HR 1.56, 95% CI 1.37 to 1.78).
: In the UK, people with dementia with higher numbers of comorbidities die earlier and have considerably higher health service usage in terms of primary care consultations, hospital admissions and prescribing. This study provides strong evidence that comorbidity is a key factor that should be considered when allocating resources and planning care for people with dementia
Household Transmission of Rotavirus in a Community with Rotavirus Vaccination in Quininde, Ecuador
Background: We studied the transmission of rotavirus infection in households in peri-urban Ecuador in the vaccination era.
Methods: Stool samples were collected from household contacts of child rotavirus cases, diarrhea controls and healthy controls following presentation of the index child to health facilities. Rotavirus infection status of contacts was determined by RT-qPCR. We examined factors associated with transmissibility (index-case characteristics) and susceptibility (householdcontact
characteristics).
Results: Amongst cases, diarrhea controls and healthy control household contacts, infection attack rates (iAR) were 55%, 8% and 2%, (n = 137, 130, 137) respectively. iARs were higher from index cases with vomiting, and amongst siblings. Disease ARs were higher when the index child was ,18 months and had vomiting, with household contact ,10 years and those sharing a room with the index case being more susceptible. We found no evidence of asymptomatic infections leading to disease transmission.
Conclusion: Transmission rates of rotavirus are high in households with an infected child, while background infections are rare. We have identified factors associated with transmission (vomiting/young age of index case) and susceptibility (young age/sharing a room/being a sibling of the index case). Vaccination may lead to indirect benefits by averting episodes or reducing symptoms in vaccinees
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