An Investigation of the Effects of Individual Differences on Technology Acceptance in the Workplace

The purpose of the current study was to test for moderating effects that conscientiousness, agreeableness, and openness to experience have on relationships in the technology acceptance model. More specifically, the current study tested for previously overlooked moderation effects that these personality traits have on the relationships between behavioral intention and its predictors (i.e. perceived ease of use, perceived usefulness, and subjective norms). A sample of 96 employees from more than 16 industries participated in the study by completing an online survey. Results of the current study displayed a significant moderation effect by agreeableness on the relationship between perceived ease of use and behavioral intention, such that the relationship was stronger for those low in agreeableness. Additionally, openness to experience was found to moderate the relationship between subjective norms and behavioral intention when controlling for time of familiarity, such that the relationship was stronger for those high in openness to experience. The theoretical and practical implications of these findings are discussed

An Investigation Into The Mechanism Of Cysteine-containing Thioredoxin Reductases: How Is Catalysis Conserved Without The Presence Of A Selenocysteine Residue?

Thiorexodin reductase (TrxR) plays a major role in maintaining cellular antioxidant homeostasis. Mammalian TrxR (mTrxR) is defined by its rare, penultimate amino acid selenocysteine (Sec), which is essential to enzyme catalysis. However, some forms of TrxR in nature do not utilize Sec. One form of TrxR that does not use Sec is mitochondrial TrxR from C. elegans (CeTrxR2). Despite not possessing a Sec residue, CeTrxR2 maintains similar catalytic activity to mTrxR. It has been hypothesized that these Cys-containing TrxRs must somehow activate their active site C-terminal vicinal disulfide bond to achieve catalytic activity comparable to Sec-containing TrxRs, which instead contain a C-terminal vicinal selenosulfide bond. In order to further the understanding of how Cys-containing TrxRs maintain catalytic activity without the presence of Sec, we studied the mechanism of CeTrxR2 by synthesizing a mutant peptide substrate, whose activity towards a truncated form of CeTrxR2 was measured and compared with the wild-type peptide substrate. Our results provide evidence that a crucial hydrogen bond in the enzyme active site induces type VIa beta-turn formation, which places amino acid residues in the correct position for catalysis

A new peat bog testate amoeba transfer function and quantitative palaeohydrological reconstructions from southern Patagonia

Testate amoebae have been extensively used as proxies for environmental change and palaeoclimate reconstructions in European and North American peatlands. The presence of these micro-organisms near the peat surface is generally significantly linked to the local water table depth (WTD) and therefore preservation of the amoeba shells downcore allows for water table reconstructions over millennia. In the last decades, attention for the palaeoecology of the southern Patagonian peat bogs has increased, partly because of the particular climatological setting under the influence of the southern westerlies. These atypical peat bogs are characterised by a wide range of water tables, from wet hollows to hummocks exceeding 100 cm above the water table, and a dominance of Sphagnum magellanicum on low lawns up to the highest hummocks. Here we present the first transfer function for this region that allows for reliable WTD reconstructions, along with 2k-year palaeorecords from local peat bogs.A modern dataset (155 samples) was sampled along transects from five bogs in 2012 and 2013. Measurements of WTD, pH and conductivity were taken for all samples. Transfer function model was based on the 2012 dataset while the 2013 samples served as an independent test set to validate the model. Besides the standard leave-one- out cross-validation we applied leave-one-site-out and leave-one transect-out cross-validation, which are effective means of verifying the degree of clustering in the dataset. To assure the environmental gradient had been evenly sampled we quantified the root-mean-squared error of prediction (RMSEP) individually for segments of this gradient.Ordinations showed a clear hydrological gradient in amoeba assemblages, with the dominant Assulina muscorum at the dry end and Amphitrema wrightianum and Difflugia globulosa at the wet end. Taxa as Nebela certesi and Nebela cockayni, possibly exclusive to the southern hemisphere, were identified and their optima and tolerances were determined. Canonical correspondence analysis showed that WTD was the most important environmental variable, accounting for 18% of the variance in amoeba assemblages. A weighted averaging-partial least squares model showed best performance in cross-validation and using the 2013 data as an independent test set. Any spatial autocorrelation was minimal although the model still appeared less effective in predicting WTD for sites not included in the training set. The segment-wise RMSEP showed that the WTD gradient was generally evenly sampled with RMSEP below 15 cm for most of the gradient, much lower than the standard deviation of the mean of all WTDs (26 cm).Preliminary results from peat cores sampled from the same peat bogs show surprisingly stable water tables over the last 2k years in Andorra bog but more variation in nearby Tierra Australis bog. Peat accumulation rates in Andorra bog are among the highest recorded in temperate bogs with around 4 m of peat accumulated during the last 2000 year

Analysing olfactory and auditory sensescapes in English cities: Sensory expectation and urban environmental perception

Cet article analyse la manière dont les individus perçoivent une gamme variée de stimuli, notamment les sons et les odeurs émis par l’activité humaine, lors de leur déambulation dans les espaces publics des villes anglaises. La démonstration s’appuie sur deux études portant sur la déambulation sensorielle (sensewalking) menées entre 2004 et 2009 indépendamment l’une de l’autre mais avec un objectif identique. La première explore la perception de l’environnement olfactif, tandis que l’autre, s’attarde sur les expériences sonores urbaines. La comparaison des résultats montre que les expectations sensorielles modifient l’attitude des individus dans le milieu urbain en induisant des niveaux de signification et de compréhension variés. Par conséquent, il y a là un défi pour les architectes et les aménageurs de créer des milieux où la prise en compte de ces différents modes de perception pourrait conduire à des réponses plus adéquates. Si l’on convient que la perception (ou la non perception) des odeurs et des sons est fortement influencée par l’environnement, il est donc fondamental que le contexte initial soit prise en compte au moment de redéfinir et de gérer les aménagements sensoriels urbains.This paper examines the role of sensory expectation in people’s experiences and perceptions of a range of different urban environments in English towns and cities by focussing upon those related to smell and sound specifically. It draws from two separate but related sensewalking studies undertaken between 2004 and 2009: one exploring urban smell experiences, the other examining urban sound experiences. In drawing from, and comparing the findings of these two studies, sensory expectations are argued as highly influential in urban place experience and perception, providing different layers of meaning and understanding of place, and presenting challenges and opportunities for architects and urban designers when creating more human-centred places in the city. In addition, perceptions of the smells and sounds themselves are revealed as highly influenced by the environmental context within which they are, or are not, detected. As a result, the authors advocate a more proactive approach to the consideration of smells and sound information when designing and managing urban sensory environments

Fore! GPR survey of the Belhus Tudor water gardens

Covid-19 restrictions allowed unique access to this site on a temporarily closed golf course. Vehicle towed ground penetrating radar survey provided rapid coverage of the site. Geophysical survey helped support local volunteer research groups. Significant remains survive despite demolition of the Tudor mansion and landscaping for the golf-course. Detailed topographic data was generated from UAV based photography through Structure from Motion

The Flow Country Peatlands of Scotland: Foreword

First paragraph: In the far north of Scotland, a vast and varied expanse of blanket peatland (Figure 1) extends across an area of 4,000 km2 within the historic counties of Caithness and Sutherland, from the foot of the mountains in the west to the coast in the east. It is the largest expanse of blanket mire in Europe (Lindsay et al. 1988) and the largest single terrestrial carbon store in the UK (Chapman et al. 2009). It is known as the Flow Country. The Flow Country has high conservation value, being of particular importance for its suite of breeding birds which includes the Common Scoter (Melanitta nigra), Greenshank (Tringa nebularia), Dunlin (Calidris alpina), Golden Plover (Pluvialis apricaria) and Hen Harrier (Circus cyaneus), and a refuge for many species normally found closer to the Arctic (Lindsay et al. 1988). The nature conservation importance of this area is reflected in the designation of over 1,300 km2 as Natura 2000 sites under the European Habitats and Birds Directives, including the largest terrestrial Special Area of Conservation (SAC) in the UK, and the current consideration of the Flow Country for World Heritage Site status

Recent geophysical survey of English monastic sites

Geophysical survey can provide additional detail even from well understood monastic sites. Extended landscape survey in rural settings can reveal wider semi-industrial monastic activity. Vehicle towed ground penetrating radar used to complement earth resistance and magnetic survey

Lack of predictive tools for conventional and targeted cancer therapy:barriers to biomarker development and clinical translation

Predictive tools, utilising biomarkers, aim to objectively assess the potential response to a particular clinical intervention in order to direct treatment. Conventional cancer therapy remains poorly served by predictive biomarkers, despite being the mainstay of treatment for most patients. In contrast, targeted therapy benefits from a clearly defined protein target for potential biomarker assessment. We discuss potential data sources of predictive biomarkers for conventional and targeted therapy, including patient clinical data and multi-omic biomarkers (genomic, transcriptomic and protein expression). Key examples, either clinically adopted or demonstrating promise for clinical translation, are highlighted. Following this, we provide an outline of potential barriers to predictive biomarker development; broadly discussing themes of approaches to translational research and study/trial design, and the impact of cellular and molecular tumor heterogeneity. Future avenues of research are also highlighted