TCP Performance Enhancement over UMTS Network with RNC Feedback

TCP optimization for wireless networks to deal with packet losses due to fading, shadowing and contention should preferably maintain TCP end-to-end semantics with minimal dependence on intermediate nodes. The development of advanced 3G networks and services makes it necessary to find a way of improving TCP's efficiency and resource utilization. Previous research on this issue suggests that TCP needs radio network feedback to distinguish wireless related losses from congestion related losses. This paper presents such a mechanism that notifies the TCP sender of any noncongestion related losses by introducing a proxy at the RNC node of the UMTS network. Only a minimal change to the standard TCP is required to achieve this. OPNET is used in this study and the simulation results show that the proposed scheme significantly improves the TCP performanc

Acute inhibition of MEK suppresses congenital melanocytic nevus syndrome in a murine model driven by activated NRAS and Wnt signaling

Congenital melanocytic nevus (CMN) syndrome is the association of pigmented melanocytic nevi with extra-cutaneous features, classically melanotic cells within the central nervous system, most frequently caused by a mutation of NRAS codon 61. This condition is currently untreatable and carries a significant risk of melanoma within the skin, brain, or leptomeninges. We have previously proposed a key role for Wnt signaling in the formation of melanocytic nevi, suggesting that activated Wnt signaling may be synergistic with activated NRAS in the pathogenesis of CMN syndrome. Some familial pre-disposition suggests a germ-line contribution to CMN syndrome, as does variability of neurological phenotypes in individuals with similar cutaneous phenotypes. Accordingly, we performed exome sequencing of germ-line DNA from patients with CMN to reveal rare or undescribed Wnt-signaling alterations. A murine model harboring activated NRASQ61K and Wnt signaling in melanocytes exhibited striking features of CMN syndrome, in particular neurological involvement. In the first model of treatment for this condition, these congenital, and previously assumed permanent, features were profoundly suppressed by acute post-natal treatment with a MEK inhibitor. These data suggest that activated NRAS and aberrant Wnt signaling conspire to drive CMN syndrome. Post-natal MEK inhibition is a potential candidate therapy for patients with this debilitating condition

Combinatorics of Open Covers VI: Selectors for Sequences of Dense Sets

We consider the following two selection principles for topological spaces: [Principle 1:] { For each sequence of dense subsets, there is a sequence of points from the space, the n-th point coming from the n-th dense set, such that this set of points is dense in the space; [Principle 2:]{ For each sequence of dense subsets, there is a sequence of finite sets, the n-th a subset of the n-th dense set, such that the union of these finite sets is dense in the space. We show that for separable metric space X one of these principles holds for the space C_p(X) of realvalued continuous functions equipped with the pointwise convergence topology if, and only if, a corresponding principle holds for a special family of open covers of X. An example is given to show that these equivalences do not hold in general for Tychonoff spaces. It is further shown that these two principles give characterizations for two popular cardinal numbers, and that these two principles are intimately related to an infinite game that was studied by Berner and Juhasz

The specificity and patterns of staining in human cells and tissues of p16INK4a antibodies demonstrate variant antigen binding

The validity of the identification and classification of human cancer using antibodies to detect biomarker proteins depends upon antibody specificity. Antibodies that bind to the tumour-suppressor protein p16INK4a are widely used for cancer diagnosis and research. In this study we examined the specificity of four commercially available anti-p16INK4a antibodies in four immunological applications. The antibodies H-156 and JC8 detected the same 16 kDa protein in western blot and immunoprecipitation tests, whereas the antibody F-12 did not detect any protein in western blot analysis or capture a protein that could be recognised by the H-156 antibody. In immunocytochemistry tests, the antibodies JC8 and H-156 detected a predominately cytoplasmic localised antigen, whose signal was depleted in p16INK4a siRNA experiments. F-12, in contrast, detected a predominately nuclear located antigen and there was no noticeable reduction in this signal after siRNA knockdown. Furthermore in immunohistochemistry tests, F-12 generated a different pattern of staining compared to the JC8 and E6H4 antibodies. These results demonstrate that three out of four commercially available p16INK4a antibodies are specific to, and indicate a mainly cytoplasmic localisation for, the p16INK4a protein. The F-12 antibody, which has been widely used in previous studies, gave different results to the other antibodies and did not demonstrate specificity to human p16INK4a. This work emphasizes the importance of the validation of commercial antibodies, aside to the previously reported use, for the full verification of immunoreaction specificity

The regenerating skeletal muscle niche drives satellite cell return to quiescence

Skeletal muscle stem cells, or satellite cells (SCs), are essential to regenerate and maintain muscle. Quiescent SCs reside in an asymmetric niche between the basal lamina and myofiber membrane. To repair muscle, SCs activate, proliferate, and differentiate, fusing to repair myofibers or reacquiring quiescence to replenish the SC niche. Little is known about when SCs reacquire quiescence during regeneration or the cellular processes that direct SC fate decisions. We find that most SCs reacquire quiescence 5&ndash;10 days after muscle injury, following differentiation and fusion of most cells to regenerate myofibers. Single-cell sequencing of myogenic cells in regenerating muscle identifies SCs reacquiring quiescence and reveals that noncell autonomous signaling networks influence SC fate decisions during regeneration. SC transplantation experiments confirm that the regenerating environment influences SC fate. We define a window for SC repopulation of the niche, emphasizing the temporal contribution of the regenerative muscle environment on SC fate. &nbsp;</p

Exploring the Trade-offs of Aggregated versus Disaggregated Architectures for Environmental Monitoring in Low-Earth Orbit

Traditionally, government space agencies have developed aggregated systems that co-host multiple capabilities on shared spacecraft buses. However, in response to cost growth and schedule delays on past programs, leaders in the government space community have expressed an interest in disaggregation, or distributing their capabilities across multiple spacecraft. Since their aggregated National Polar-orbiting Operational Satellite System (NPOESS) program was cancelled in 2010, both the National Oceanic and Atmospheric Administration (NOAA) and the Department of Defense (DoD) have investigated opportunities to reduce program costs through disaggregation. This paper expands their initial investigation and explores the cost impacts of aggregation and disaggregation across a large trade space of candidate architectures for environmental monitoring in low-Earth orbit. We find that on average, aggregated architectures are less costly than fully disaggregated ones but also find opportunities for cost savings by developing semi-aggregated systems, or systems with one or two satellites per orbital plane. Finally, we investigate several trades that are currently under consideration by NOAA and the DoD and make recommendations for future environmental monitoring systems in low-Earth orbit.Massachusetts Institute of Technology (Sandia Corporation Excellence in Engineering Graduate Fellowship)Skolkovo Institute of Science and Technolog