The use of Human Subjects in Biomedical Research: A Problematic Scientific Past Shapes Present Ethical Challenges

The ethics of human experimentation is a relatively new phenomenon in medicine. The Nuremberg Code and the Helsinki Declaration focused on informed consent in human experimentation. More recently, ethicists have begun to emphasize that, beyond the need for consent, the \"content\" of the experiment also needs to be ethical. The method and process of the experiment must be humanizing and affirming of the subject as moral agent. The religious perspective has provided a comprehensive moral foundation, demanding respect for the subjects\' moral agency and their right to he treated as equally worthy members of the human community, thus ensuring the integrity of the subject as person

Assembly Of The First Dwarf Galaxies

Understanding the formation and evolution of the first stars and galaxies is crucial to understanding reionization, a key epoch in the history of the Universe. Detailed theoretical studies of the galaxies before and during reionization are now particularly urgent because of the wealth of observational data that will soon be provided by the next generation of telescopes, such as JWST, ALMA, LOFAR, MWA, and others. We simulate the formation of the first galaxies using cosmological smoothed particle hydrodynamics simulations. Zooming in on individual galaxies, we explore how various physical processes affect their assembly and further evolution. A highlight of our study will be the simulation of the radiation-hydrodynamics of galaxy assembly, which we will perform using our multi-frequency radiative transfer method TRAPHIC. Feedback from radiation has long been suspected to play a decisive role in galaxy formation and we will investigate its implications for observable properties of the first galaxies.Astronom

Chemical defenses of the Caribbean sponges Agelas wiedenmayeri and Agelas conifera

Previous studies have determined that Caribbean reef sponges of the genus Agelas are chemically defended from fish predation by brominated pyrrole alkaloids, and that the compounds responsible for this defense have been elucidated for one species, Agelas clathrodes. In this study, we expand our understanding of chemical defense in this common sponge genus to include the characterization of defensive metabolites in the tissues of Agelas wiedenmayeri and Agelas conifera. Bioassay-directed isolation of defensive metabolites was undertaken using fish feeding assays carried out in laboratory aquaria and in the field. Agelas wiedenmayeri contained the same two major metabolites as Agelas clathrodes, 4,5-dibromopyrrole-2-carboxylic acid (1), and oroidin (2), in addition to a small amount of bromoageliferin (7). The two major metabolites were present at higher concentrations in samples of Agelas wiedenmayeri than in Agelas clathrodes, and their relative concentrations were reversed, with Agelas wiedenmayeri on average containing more 4,5-dibromopyrrole-2-carboxylic acid (1) (2.0 mg/mL) than oroidin (2) (0.8 mg/mL). Agelas conifera contained a mixture of dimeric bromopyrrole alkaloids dominated by sceptrin (3), with <10% each of dibromosceptrin (5), bromoageliferin (7), dibromoageliferin (8), ageliferin (6), and bromosceptrin (4). Mean concentration of sceptrin (3) in sponge tissue was 5.3 mg/mL; this compound deterred feeding of reef fish in aquarium assays at 1.0 mg/mL, the lowest concentration assayed. Sceptrin (3) concentrations were higher in sponges collected in the southern Bahama Islands than those collected in the middle Bahamas, but reasons for this variation remain unclear. The structure-activity relationship of the pyrrole group was investigated by assaying derivatives of the active metabolites. Feeding deterrent activity of the molecule was enhanced by the addition of bromine to the pyrrole group, but not affected by exchange of the heteroatom from N to O or S. Combining an understanding of the structure-activity relationship of Agelas metabolites with an understanding of the variation in these metabolites across the genus may provide insight into the evolution of defensive chemistry in this highly successful taxa of pan-tropical sponges

Sandblasting nozzle

A nozzle for use with abrasive and/or corrosive materials is formed of sintered ceramic compositions having high temperature oxidation resistance, high hardness and high abrasion and corrosion resistance. The ceramic may be a binary solid solution of a ceramic oxide and silicon nitride, and preferably a ternary solid solution of a ceramic oxide, silicon nitride and aluminum nitride. The ceramic oxide is selected from a group consisting of Al2O3, Y2O3 and Cr2O3, or mixtures of those compounds. Titanium carbide particles are dispersed in the ceramic mixture before sintering. The nozzles are encased for protection from external forces while in use by a metal or plastic casing

The First Supernovae: Source Density And Observability Of Pair Instability Supernovae

Theoretical models predict that some of the first stars ended their lives as extremely energetic Pair Instability Supernovae (PISNe). With energies approaching 10(53) erg, these supernovae are expected to be within the detection limits of the upcoming James Webb Space Telescope (JWST) allowing observational constraints to be placed on the properties of the first stars. We estimate the source density of PISNe using a semi-analytic Press-Schecter based approach informed by cosmological simulations, with an upper limit of similar to 0.2 PISNe visible per JWST field of view at any given time. We find that the main obstacle to observing PISNe is their scarcity rather than their faintness. Given this we suggest a mosaic style search strategy for detecting PISNe from the first stars.Astronom

A technique for obtaining plasma-sheath configurations and ion optics for an electron- bombardment ion thrustor

Plasma boundaries and ion trajectories for accelerator system of electron bombardment ion thrusto

Black Hole Feedback On The First Galaxies

We study how the first galaxies were assembled under feedback from the accretion onto a central black hole (BH) that is left behind by the first generation of metal-free stars through self-consistent, cosmological simulations. X-ray radiation from the accretion of gas onto BH remnants of Population III (Pop III) stars, or from high-mass X-ray binaries (HMXBs), again involving Pop III stars, influences the mode of second generation star formation. We track the evolution of the black hole accretion rate and the associated X-ray feedback starting with the death of the Pop III progenitor star inside a minihalo and following the subsequent evolution of the black hole as the minihalo grows to become an atomically cooling galaxy. We find that X-ray photoionization heating from a stellar-mass BH is able to quench further star formation in the host halo at all times before the halo enters the atomic cooling phase. X-ray radiation from a HMXB, assuming a luminosity close to the Eddington value, exerts an even stronger, and more diverse, feedback on star formation. It photoheats the gas inside the host halo, but also promotes the formation of molecular hydrogen and cooling of gas in the intergalactic medium and in nearby minihalos, leading to a net increase in the number of stars formed at early times. Our simulations further show that the radiative feedback from the first BHs may strongly suppress early BH growth, thus constraining models for the formation of supermassive BHs.Astronom