Chemical defenses of the Caribbean sponges Agelas wiedenmayeri and Agelas conifera

Previous studies have determined that Caribbean reef sponges of the genus Agelas are chemically defended from fish predation by brominated pyrrole alkaloids, and that the compounds responsible for this defense have been elucidated for one species, Agelas clathrodes. In this study, we expand our understanding of chemical defense in this common sponge genus to include the characterization of defensive metabolites in the tissues of Agelas wiedenmayeri and Agelas conifera. Bioassay-directed isolation of defensive metabolites was undertaken using fish feeding assays carried out in laboratory aquaria and in the field. Agelas wiedenmayeri contained the same two major metabolites as Agelas clathrodes, 4,5-dibromopyrrole-2-carboxylic acid (1), and oroidin (2), in addition to a small amount of bromoageliferin (7). The two major metabolites were present at higher concentrations in samples of Agelas wiedenmayeri than in Agelas clathrodes, and their relative concentrations were reversed, with Agelas wiedenmayeri on average containing more 4,5-dibromopyrrole-2-carboxylic acid (1) (2.0 mg/mL) than oroidin (2) (0.8 mg/mL). Agelas conifera contained a mixture of dimeric bromopyrrole alkaloids dominated by sceptrin (3), with <10% each of dibromosceptrin (5), bromoageliferin (7), dibromoageliferin (8), ageliferin (6), and bromosceptrin (4). Mean concentration of sceptrin (3) in sponge tissue was 5.3 mg/mL; this compound deterred feeding of reef fish in aquarium assays at 1.0 mg/mL, the lowest concentration assayed. Sceptrin (3) concentrations were higher in sponges collected in the southern Bahama Islands than those collected in the middle Bahamas, but reasons for this variation remain unclear. The structure-activity relationship of the pyrrole group was investigated by assaying derivatives of the active metabolites. Feeding deterrent activity of the molecule was enhanced by the addition of bromine to the pyrrole group, but not affected by exchange of the heteroatom from N to O or S. Combining an understanding of the structure-activity relationship of Agelas metabolites with an understanding of the variation in these metabolites across the genus may provide insight into the evolution of defensive chemistry in this highly successful taxa of pan-tropical sponges

Accuracy analysis of the box-counting algorithm

Accuracy of the box-counting algorithm for numerical computation of the fractal exponents is investigated. To this end several sample mathematical fractal sets are analyzed. It is shown that the standard deviation obtained for the fit of the fractal scaling in the log-log plot strongly underestimates the actual error. The real computational error was found to have power scaling with respect to the number of data points in the sample ($n_{tot}$). For fractals embedded in two-dimensional space the error is larger than for those embedded in one-dimensional space. For fractal functions the error is even larger. Obtained formula can give more realistic estimates for the computed generalized fractal exponents' accuracy.Comment: 3 figure

The First Supernovae: Source Density And Observability Of Pair Instability Supernovae

Theoretical models predict that some of the first stars ended their lives as extremely energetic Pair Instability Supernovae (PISNe). With energies approaching 10(53) erg, these supernovae are expected to be within the detection limits of the upcoming James Webb Space Telescope (JWST) allowing observational constraints to be placed on the properties of the first stars. We estimate the source density of PISNe using a semi-analytic Press-Schecter based approach informed by cosmological simulations, with an upper limit of similar to 0.2 PISNe visible per JWST field of view at any given time. We find that the main obstacle to observing PISNe is their scarcity rather than their faintness. Given this we suggest a mosaic style search strategy for detecting PISNe from the first stars.Astronom

A technique for obtaining plasma-sheath configurations and ion optics for an electron- bombardment ion thrustor

Plasma boundaries and ion trajectories for accelerator system of electron bombardment ion thrusto

Solar electric propulsion system tests

Design and performance of solar-powered electric propulsion system for interplanetary space exploratio

[Ir]responsible leadership: addressing management and leadership curricula biases

Irresponsible leadership (IL) research vis-a-vis curricular development in management education receives a modicum of attention, particularly in comparison to responsible leadership (RL). At best, IL is embedded in topics such as leadership and management development, corporate social responsibility (CSR) or business ethics. The report problematizes IL embeddedness and examines irresponsible leader behaviors and practices, particularly through the lens of multinational corporations (MNCs) in the context of CSR/CSI (corporate social irresponsibility). IL is defined, and the authors argue for stand-alone IL courses in the management/leadership curricula, as embedding alone does very little to reflect the growing problems associated with IL behavior and practices. Hence, management curricula bias is addressed by emphasizing the criticality of IL education to improve RL understanding, pedagogy, and professional practices in work organizations. The authors adopt a bricolage philosophy which allows for ontological and epistemological flexibility, useful for investigating under-researched issues. The targeted audiences are people involved in management/leadership education, learning and development, including academics involved in curricula development studies, as well as management consultants, and HR partners. Key words: Irresponsible leadership, Responsible Leadership, HRM, Management, Curricula development, Higher Education, Corporate Social Responsibility, Corporate Social Irresponsibility, Sustainability Teaching and Learnin

Apparatus for Hot Impact Testing of Material Specimens

An apparatus for positioning and holding material specimens is a major subsystem of a system for impact testing of the specimens at temperatures up to 1,500 C. This apparatus and the rest of the system are designed especially for hot impact testing of advanced ceramics, composites, and coating materials. The apparatus includes a retaining fixture on a rotating stage on a vertically movable cross support driven by a linear actuator. These components are located below a furnace wherein the hot impact tests are performed (see Figure 1). In preparation for a test, a specimen is mounted on the retaining fixture, then the cross support is moved upward to raise the specimen, through an opening in the bottom of the furnace, to the test position inside the furnace. On one side of the furnace there is another, relatively small opening on a direct line to the specimen. Once the specimen has become heated to the test temperature, the test is performed by using an instrumented external pressurized-gas-driven gun to shoot a projectile through the side opening at the specimen

Magnetization Reversal Processes in the Nanocrystalline Fe-Co-Zr-Ti-Pr-B Magnets

Magnetization reversal processes in the magnets derived from the Fe 60 Co 13 Zr 1 Ti 3 Pr 9 B 14 alloy were investigated. It was shown that the processing technique affects the magnetization reversal processes. For the nanocrystalline ribbon samples pinning of the domain walls arises at low external magnetic fields while nucleation of reversed domains occurs at higher fields. However, the nucleation fields are lower than the pinning fields for the nanocrystalline rod and tube samples produced by suction-casting technique

Contact Thermocouple Methodology and Evaluation for Temperature Measurement in the Laboratory

Laboratory testing of advanced aerospace components very often requires highly accurate temperature measurement and control devices, as well as methods to precisely analyze and predict the performance of such components. Analysis of test articles depends on accurate measurements of temperature across the specimen. Where possible, this task is accomplished using many thermocouples welded directly to the test specimen, which can produce results with great precision. However, it is known that thermocouple spot welds can initiate deleterious cracks in some materials, prohibiting the use of welded thermocouples. Such is the case for the nickel-based superalloy MarM-247, which is used in the high temperature, high pressure heater heads for the Advanced Stirling Converter component of the Advanced Stirling Radioisotope Generator space power system. To overcome this limitation, a method was developed that uses small diameter contact thermocouples to measure the temperature of heater head test articles with the same level of accuracy as welded thermocouples. This paper includes a brief introduction and a background describing the circumstances that compelled the development of the contact thermocouple measurement method. Next, the paper describes studies performed on contact thermocouple readings to determine the accuracy of results. It continues on to describe in detail the developed measurement method and the evaluation of results produced. A further study that evaluates the performance of different measurement output devices is also described. Finally, a brief conclusion and summary of results is provided