Influence of structural changes of Co78Si9B13 metallic glass on magnetic properties

The primary crystallization of Co78Si9B13 metallic glass starts at 648 K and as a consequence of this the ε-Co(Si) phase with needle morphology is created. The second stage of crystallization (at 773 K) is the eutectic and as a result of this α-Co(Si) and boron phases: (Co,Si)3B, (Co,Si)2B are formed. The crystallites of these phases have layer morphology. These characteristic morphologies in the first and second stages lead to the increase in coercivity

Mieszkania zintegrowane jako element ekosystemu – analiza autorskiej koncepcji „Świat idealny”

Housing for people with disabilities is one of the basic areas of normalization. Such independence of the intellectually disabled is still rare in Poland. The text tries to capture the significance of adults with intellectual disabilities finding their independent housing, as a part of “The Perfect World” original concept focusing on the lifelong support of the people with more severe mental dysfunction.Barbour R. (2011), Badania fokusowe, Wydawnictwo Naukowe PWN, Warszawa. Bezpieczna samodzielność – projekt mieszkania zintegrowanego (2014), Instytut Twórczej Integracji, Sosnowiec. Bogenschutz M., Novak-Amado A. (2016), Social Inclusion for People with IDD, [w:] Critical Issues in Intellectual and Developmental Disabilities: Contemporary Research, Practice, and Policy, AAIDD, Washington D.C. Bronfenbrenner U. (1979), The ecology of human development, Harvard University Press, Cambridge. Brzezińska A. (2007), Społeczna psychologia rozwoju, Wydawnictwo Naukowe SCHOLAR, Warszawa. Durek I. (2015), „Świat idealny”–systemowa koncepcja pracy z dzieckiem niepełnosprawnym intelektualnie, Zeszyty Naukowe Wyższej Szkoły Humanitas 11/2015, Oficyna Wydawnicza „Humanitas”, Sosnowiec. Gajdzica Z. (2004), Status rodzinny i zawodowy osób z lekkim upośledzeniem umysłowym na tle zmiany społecznej, [w:] Człowiek z niepełnosprawnością intelektualną. Wybrane problemy społecznego funkcjonowania oraz rehabilitacji osób z niepełnosprawnością intelektualną, t. II, Z. Janiszewska-Nieścioruk (red.), Oficyna Wydawnicza "Impuls", Kraków. Gawlik, K. (2012). Badania fokusowe, [w]: Badania jakościowe. Metody i narzędzia (tom 2), D. Jemielniak (red.), Wydawnictwo Naukowe PWN, Warszawa. Kopeć D. (2012), Zapobieganie niepełnosprawności intelektualnej w świetle rozważań Amerykańskiego Stowarzyszenia Niepełnosprawności Intelektualnej Rozwojowej (AAIDD), „Kultura-Społeczeństwo-Edukacja” nr 2. Kościelska M. (2004), Niechciana seksualność, Jacek Santorski & Co, Warszawa. Krause A. (2011), Współczesne paradygmaty pedagogiki specjalnej, Oficyna Wydawnicza „Impuls”, Kraków. Krause A., Żyta A., Nosarzewska S. (2010), Normalizacja środowiska społecznego osób z niepełnosprawnością intelektualną, Wydawnictwo Edukacyjne AKAPIT, Toruń. Lisek-Michalska J. (2013), Badania fokusowe : problemy metodologiczne i etyczne, Wydawnictwo Uniwersytetu Łódzkiego, Łódź. Lityńska B. (2016), Wiersze nowe, VigodaPress, Warszawa. Marciniak-Madejska N. (2013), Życie dorosłych osób z niepełnosprawnością intelektualną - problematyczność realizacji potrzeby seksualności i niezależności w perspektywie rozwoju tożsamości, „Interdyscyplinarne Konteksty Pedagogiki Specjalnej” nr 2. Oleś P. K. (2011), Psychologia człowieka dorosłego : ciągłość - zmiana – integracja, Wydawnictwo Naukowe PWN, Warszawa. Parys K. (2013), Przestrzeń dla kreatywności uczniów z niepełnosprawnością intelektualną w stopniu lekkim, Oficyna Wydawnicza „Impuls”, Kraków. Pichalski R. (2003), Refleksje nad dorosłością, [w]: Dorosłość, niepełnosprawność, świat współczesny, K. Rzedzicka, A. Kobylańska (red.), Oficyna Wydawnicza „Impuls”, Kraków. Schalock R.L. i in (2012), User’s Guide. To Accompany the 11th ed. of Intellectual Disability: Definition, Classification and Systems of Supports, AAIDD, Washington D.C. Schalock R.L. i in. (2010), Intellectual Disability: Definition, Classification and Systems of Supports. 11th ed., AAIDD, Washington D.C. Schwarte N., Oberste-Ufer R. (1997), LEWO, Lebensqualität in Wohnstätten für erwachsene Menschen mit geistiger Behinderung, Marburg. Simplican S.C. i in. (2015), Defining social inclusion of people with intellectual and developmental disabilities: An ecological model of social networks and community participation, “Research in Developmental Disabilities” nr 38, https://doi.org/10.1016/j.ridd.2014.10.008. Wolfensberger W. (1972), The Principle of Normalisation in Human Services, Toronto. Zawiślak A. (2011), Jakość życia osób dorosłych z niepełnosprawnością intelektualną, DIFIN, Warszawa. Żółkowska T. (2011), Normalizacja – niedokończona teoria praktyki, „Niepełnosprawność” nr 5

Synthesis and antibacterial activity of new sulfonamide isoxazolo[5,4-b]pyridine derivatives

A series of novel sulfonamide isoxazolo[5,4-b]pyridines were synthesized. The substrates for their synthesis were 3-aminoisoxazolo[5,4-b]pyridine and selected aryl sulfonic chlorides, chlorosulfonic acid and selected amines. Reactions were carried out using the classical and microwave methods. Selected compounds were tested towards antibacterial and antiproliferative activity. The structure of the obtained new derivatives was determined by elemental analysis and acquired IR and 1H NMR spectra. Among the tested compounds: N-isoxazolo[5,4-b]pyridine-3-yl-benzenesulfonamide (2) and N-isoxazolo[5,4-b]pyridine-3-yl-4-methylbenzene-sulfonamide (5) showed antimicrobial activity towards Pseudomonas aeruginosa (ATCC 27853) and Escherichia coli (ATCC 25922) at doses: 125, 250 and 500 μg. Both compounds showed a 50% inhibition of proliferation of breast carcinoma cell line MCF7 at concentrations of 152.56 μg/mL and 160 161.08 Ïg/mL, respectively

Assessment of the health risk associated with exposure to heavy metals present in particulate matter deposition in the Małopolska Province

The aim of the study was to investigate the content of trace elements in deposited particulate matter and to estimate the health risk to Kraków inhabitants, caused by the exposure to heavy metals in particulate matter deposition. The qualitative and quantitative assessments of selected heavy metals in deposited particulate matter have been carried out in the city of Kraków (Małopolska, southern Poland, 5 measuring points) for seven months, between February and September 2017. A comparative study was conducted at the same time in Małopolska (5 measuring points). The deposited particulate matter was collected gravitationally, using measurement plates covered with aluminum foil and paraffin jelly. The largest deposition of particulate matter was found in May and June. The highest amount of deposited particulate matter and metals present in it was determined in Kraków. The Hazard Quotient (HQ) evaluation for non-carcinogenic effect showed low risk for each metal. In the case of lead in particulate matter, the carcinogenic risk value did not reach 10−6 hence this risk is acceptable. The total carcinogenic risk for all routes of exposure to cadmium was higher, indicating the risk of cancer in children and adults, with children more exposed. However, the carcinogenic risk for cadmium was also acceptable. The study showed that the problem of poor air quality concerns not only the city of Kraków, but also the entire Małopolska region. Elevated metal concentrations in particulate matter indicate the need for monitoring it in the air

The susceptibility of patients' with psoriasis nail plates to fungal infection

The objective of the study was evaluation of the finger and toe nail fragments collected from psoriasis patients’ susceptibility to fungal infection. Toe and finger nail fragments (scrapings) collected from 34 psoriasis patients and 27 healthy volunteers were experimentally ex vivo infected with C. albicans and T. mentagrophytes strains. After incubation, the effectiveness of infection was evaluated in clarified microscopic preparations on the basis of the number of hyphe penetrating the nail fragments. The statistical analysis revealed that toenails but not fingernails of the psoriasis patients were significantly more susceptible to C. albicans infection. No significant difference was found between the susceptibility of both finger and toe nails to T. mentagrophytes infection between the psoriasis patients and the controls

Necrotising enterocolitis in preterm infants : epidemiology and antibiotic consumption in the polish neonatology network neonatal intensive care units in 2009

The aim of this study was to describe the epidemiology of necrotising enterocolitis (NEC), antibiotic consumption and the usefulness of microbiological tests in very low birth weight (VLBW) Polish newborns. METHODS: Prospective surveillance was performed in the year 2009 by local infection control teams. The study covered 910 infants hospitalized in six Polish neonatal intensive care units. Two kinds of indicators were used for the description of antibiotic usage: the duration of treatment (days of treatment, DOTs) and the defined daily dose (DDD). RESULTS: NEC incidence was 8.7% and fatality rate was 19%. Chorioamnionitis, late gestational age and low birth weight were identified as risk factors for NEC. Catheterization, mechanical ventilation and other selected procedures were used considerably longer in newborns with NEC than in the remaining neonates. Total usage of antibiotics reached 2.9 DDDs or 1.437 days; the average use of drugs per case of NEC amounted to 0.47 DDD or 23.2 DOTs. The level of antibiotic usage was analysed with correlation to microbiological tests performed and it was non-significantly greater in the group of children with NEC in whom the tests were performed. CONCLUSIONS: A high risk of developing NEC is closely associated with VLBW and with inflammation of the amnion during labour. We observed no relationship between the consumption of antibiotics in neonates with NEC and positive results of microbiological testing indicating sepsis accompanying NEC or gut colonization with pathogens

Szybka metoda oceny stężenia witaminy A, witaminy E oraz kotyniny w surowicy krwi kobiet z śródnabłonkową neoplazją (CIN)i rakiem szyjki macicy

Abstract Objective: The aim of this study was to elaborate on the analytical method for quantitative determination of retinol and α-tocopherol in serum of women diagnosed with CIN and cervical cancer. The basic problem in the analysis of the vitamins content in biological material is their low physiological concentration level and instability. Liquid chromatography with diode array detector (DAD) was applied. Material and methods: The material consisted of serum and urine collected from 12 women diagnosed with cervical intraepithelial neoplasia (CIN) and 16 diagnosed with cervical cancer. The method was evaluated for the following parameters: linearity, recovery, sensitivity, precision, accuracy, selectivity, stability, limit of quantification (LOQ) and limit of detection (LOD). Results: Results showed good linearity (r2 ≥0,99) in the range 0,1μg/ml-10mg/ml for retinol and 0,25μg/ml-15μg/ml for α-tocopherol. The Lower Limit of Detection was 0,15μg/ml for vitamin E and 0,05μg/ml for vitamin A. The within-run R.S.Ds were below 5,2% at all concentration levels and the between-run R.S.Ds were below 10,0% at all concentration levels. Conclusions: The advantage of this method is that it measures both compounds in a more rapid, reproducible and accurate manner when compared to the previous HPLC studies. The compounds (vitamin A and E and internal standards) are measured in the same sample at the same time. Quantitative determination of cotinine may reveal active smokers and subjects exposed to environmental tobacco smoke, which is independent measurable carcinogenetic co-factor. The following study is a part of a project determining non-viral causative agents in cervical carcinogenesis.Streszczenie Cel pracy: Celem niniejszej pracy jest ocena przydatności analitycznej metody oznaczania ilościowego retinolu i alfa-tokoferolu w surowicy kobiet z rozpoznaną śródnabłonkową neoplazją (CIN) i rakiem szyjki macicy. Głównym problemem w analizowaniu zawartości witamin w materiale biologicznym jest ich niskie fizjologiczne stężenie i niestabilność. W niniejszym badaniu zastosowano metodę ciekłej chromatografii z detektorem diodowym (DAD). Materiał i metodyka: Materiał badawczy stanowiło osocze i mocz, 12 kobiet z rozpoznaną śródnabłonkową neoplazją szyjki macicy (CIN) i 16 z rakiem szyjki macicy. Metodę oceniono pod kątem następujących parametrów: liniowość, powtarzalność, czułość, precyzja, dokładność, selektywność, stabilność, granica kwantyfikacji (limit of quantification - LOQ) i detekcji (limit of detection - LOD). Wyniki: Uzyskano wysoka liniowość (r2 ≥0,99) w zasięgu 0,1μg/ml-10mg/ml dla retinolu i 0,25μg/ml-15μg/ml dla alfa-tokoferolu. Dolna granica wykrywalności wyniosła 0,15μg/ml dla witaminy E i 0,05μg/ml dla witaminy A. Zasięg metody R.S.Ds wyniósł 5,2% we wszystkich poziomach stężeń a interwałowy zasięg R.S.Ds poniżej 10,0% we wszystkich poziomach stężeń. Wnioski: Zaleta zbadanej metody jest fakt, iż można przy jej pomocy uzyskać wyniki w szybszy, bardziej powtarzalny i dokładniejszy sposób, niż w opisywanych w literaturze badaniach z użyciem HPLC. Dodatkową zaleta stosowanej metody jest możliwość pomiaru z tej samej próbki witamin A i E. Ilościowa ocena stężenia kotyniny może wskazać pacjentki, będące aktywnymi palaczkami lub narażonymi na palenie bierne. W aspekcie karcinogenezy w obrębie szyjki macicy może być to cenna wiadomość dotycząca istotnego a często zatajanego kofaktora nowotworzenia. Niniejsze badanie jest częścią projektu oceniającego pozawirusowe czynniki onkogenne w procesie karcinogenezy w obr´bie szyjki macicy

Luminescence of SiO2-BaF2:Tb3+, Eu3+ nano-glass-ceramics made from sol-gel method at low temperature

The synthesis and characterization of multicolor light-emitting nanomaterials based on rare earths (RE3+) are of great importance due to their possible use in optoelectronic devices, such as LEDs or displays. In the present work, oxyfluoride glass-ceramics containing BaF2 nanocrystals co-doped with Tb3+, Eu3+ ions were fabricated from amorphous xerogels at 350 C. The analysis of the thermal behavior of fabricated xerogels was performed using TG/DSC measurements (thermogravimetry (TG), differential scanning calorimetry (DSC)). The crystallization of BaF2 phase at the nanoscale was confirmed by X-ray diffraction (XRD) measurements and transmission electron microscopy (TEM), and the changes in silicate sol–gel host were determined by attenuated total reflectance infrared (ATR-IR) spectroscopy. The luminescent characterization of prepared sol–gel materials was carried out by excitation and emission spectra along with decay analysis from the 5D4 level of Tb3+. As a result, the visible light according to the electronic transitions of Tb3+ (5D4 ! 7FJ (J = 6–3)) and Eu3+ (5D0 ! 7FJ (J = 0–4)) was recorded. It was also observed that co-doping with Eu3+ caused the shortening in decay times of the 5D4 state from 1.11 ms to 0.88 ms (for xerogels) and from 6.56 ms to 4.06 ms (for glass-ceramics). Thus, based on lifetime values, the Tb3+/Eu3+ energy transfer (ET) efficiencies were estimated to be almost 21% for xerogels and 38% for nano-glass-ceramics. Therefore, such materials could be successfully predisposed for laser technologies, spectral converters, and three-dimensional displays

Effects of exercise of different intensity on gut peptides, energy intake and appetite in young males

Introduction and research aims: The aim of the work was an evaluation of the impact of physical exertion on the regulating of food intake and digestive system hormone release as well as the partly connected phenomenon of evaluating the subjective sensation of hunger and the amount of food consumed at various time following physical exercise. Materials and methods: The tests covered 12 young, healthy men, for whom the effects of physical exertion of a moderate and high intensity on the subjective sensation of hunger/satiety, evaluated by means of visual analogue scales, on food intake as well as on the metabolic and hormonal parameters were tested. Results: Physical exertion resulted in a fall in the subjective sensation of hunger, but only following intensive exertion was this statistically significant. The intake of food was greater after exertion when compared to the control group. Moderate exertion resulted in a statistically significant but short-lived increase in the ghrelin level. This effect was not observed after intensive exertion, while in those tests during the post-meal period there occurred a fall in the concentration of ghrelin in the plasma. After exertion a physical fall was observed in the concentration of insulin in the plasma, for the intake of food resulted in a notable increase in its level. Conclusions: Physical highly intensive exertion, results in a temporary reduction in the subjective sensation of hunger but leads to an increased food intake. The current research suggests that moderate but not intensive physical exertion stimulates the secretion of ghrelin