Utjecaj sadržaja lijeka i veličine aglomerata na tabletiranje i oslobađanje bromheksin hidroklorida iz aglomerata s talkom pripremljenih kristalokoaglomeracijom

The objective of the investigation was to study the effect of bromhexine hydrochloride (BXH) content and agglomerate size on mechanical, compressional and drug release properties of agglomerates prepared by crystallo-co-agglomeration (CCA). Studies on optimized batches of agglomerates (BXT1 and BXT2) prepared by CCA have showed adequate sphericity and strength required for efficient tabletting. Trend of strength reduction with a decrease in the size of agglomerates was noted for both batches, irrespective of drug loading. However, an increase in mean yield pressure (14.189 to 19.481) with an increase in size was observed for BXT2 having BXH-talc (1:15.7). Surprisingly, improvement in tensile strength was demonstrated by compacts prepared from BXT2, due to high BXH load, whereas BXT1, having a low amount of BXH (BXH-talc, 1:24), showed low tensile strength. Consequently, increased tensile strength was reflected in extended drug release from BXT2 compacts (Higuchi model, R2 = 0.9506 to 0.9981). Thus, it can be concluded that interparticulate bridges formed by BXH and agglomerate size affect their mechanical, compressional and drug release properties.Cilj rada bio je praćenje utjecaja sadržaja bromheksidin hidroklorida (BXH) i veličine aglomerata na mehanička svojstva, kompresivnost i oslobađanje ljekovite tvari iz aglomerata pripravljenih kristalokoaglomeracijom (CCA). Optimizirani pripravci aglomerata (BXT1 i BXT2) pripravljeni CCA metodom pokazuju adekvatnu sferičnost i čvrstoću potrebnu za učinkovito tabletiranje. U oba pripravka se smanjenjem veličine aglomerata smanjivala i čvrstoća, neovisno o količini ljekovite tvari. Međutim, povećanje prosječnog tlaka s povećanjem veličine čestica primijećeno je u pripravku BXT2 s omjerom BXH-talk 1:15,7. Iznenađuje da su kompakti pripravljeni iz BXT2, s visokim sadržajem BXH, imali veću vlačnu čvrstoću, dok su BXT1 s niskim sadržajem BXH (BXH-talk, 1:24) imali manju čvrstoću. Veća vlačna čvrstoća imala je za posljedicu produljeno oslobađanje ljekovite tvari iz BXT2 (Higuchijev model, R2 = 0,9506 do 0,9981). Može se zaključiti da mostovi među česticama BXH i veličina aglomerata utječu na njihova mehanička i kompresivna svojstva te na oslobađanje ljekovite tvari

Fisheries geographical information system for Greater Mumbai region in Maharashtra, India

Geographical information system (GIS) is an invaluable decision support tool, designed to address spatially related problems for management of natural resources. The power of GIS lies in its ability to visualise and relate various types of geo-referenced spatial and non-spatial data allowing users to analyse them. In India, use of GIS in fisheries management is yet to find its rightful place. An effort has been made in the present study to design and organise a fisheries spatial information system for Greater Mumbai region in Maharashtra to serve as a macro-level database for the planners and administrators, which can be used for querying, analysing and displaying datasets in the form of graphs and summarised tabular data for all the fisheries infrastructural facilities. This GIS will be of immense help to planners, managers and administrators in quick storing, retrieving and updating the required information for management of fisheries in Greater Mumbai region

Adolescent Neuroblastoma of Lower Limb

Neuroblastoma is an embryonic tumour of neural crest origin, commonly seen in children with upper abdomen involvement. Rarely neuroblastomas present in adolescents and adults involving lower limb. Histopathologically neuroblastoma of lower limb can be confused with other small round cell tumour especially with Ewing’s sarcoma and rhabdomyosarcoma. A 16 year old male presented with 15x11cm swelling, pain and multiple discharging sinuses of right leg since 4 months. Routine haematological and biochemical analysis were within normal limits. Radiology of right leg showed large soft tissue swelling encompassing the pathological fracture of tibia and bowing of fibula. Fine needle aspiration of the swelling revealed malignant small round cell tumour. Histopathology revealed poorly differentiated neuroblastoma of lower limb. The immunohistochemistry of Synaptophysin and Chromogranin were positive and CD 99 was negative. Neuroblastoma diagnosed at unusual site with uncommon age has poor prognosis. Hence, one must keep in mind the differential diagnosis of neuroblastoma as one of the differential diagnosis in evaluating the soft tissue tumours of lower limb

"Evaluation of The Public's Recognition, Approval, And Perspectives On Renewable Energy In Panvel"

This study addresses the critical role of public sentiment in shaping energy portfolios and policies, with a focus on the often-neglected grassroots perspectives in developing nations. Conducted in Panvel, the research surveyed 1000 respondents from urban and rural areas, revealing strong approval (73%) for renewable energy technologies and a widespread belief (91%) in their potential to reduce electricity costs. Emphasizing the need for a more inclusive energy policy approach, the study highlights a high level of awareness (69.5%) among Panvel residents. The findings underscore the importance of understanding public attitudes to inform effective and democratic energy policy formulation, shedding light on the significance of a holistic approach that considers both urban and rural perspectives. &nbsp

Purse seine fishing in Maharashtra

Purse seines are one of the important gears operated along the west coast of India for harvesting shoaling pelagic fishes, mostly oil sardine and mackerel. Purse seine fishing method invented to harvest the large shoal of pelagic fish in Maine, United State of America during 1830’s later is was spread to Norway, Sweden, Japan etc. In India purse seine was introduced on experimental basis in 1954 under Indo-Norwegian project off Quilon, Kerala and other attempt was made in Goa in 1957 when the territory was still ruled by Portuguese. The commercial purse seining taken up by the fishers in Karnataka during the mid 1970s was later adopted by the fishers in Kerala and Goa. In Maharashtra, fishers from the southern region (Ratnagiri and Sindhdurg) adopted purse seine fishing in late eighties and Mirkarwada emerged as a major base of operation for these purse seiners. In northern Maharashtra, fishers were mostly engaged in set bagnet (Dol nets) and trawl fishing until the late 1990s when a few trawl fishers shifted to purse seine fishing expecting better economic prospects

Evaluation of soybean (Glycine max) germplasm for some important morphological traits using multivariate analysis

Based on the results obtained in present study, it is advocated that the genotypes namely MACS 1201, SL 788 and MASU 449 were identified as the best genotypes for grain yield. The cluster VII (CSB 08-09) and VI (SL 778, Dsb 20, MACS 1311, RKS 61, BAUS 40) was most diverse to each other. Hence, crossing between these cluster would help to accumulate favorable and desirable alleles for further improvement in grain yield and its component in soybean

Navigating the Evolution: A Comprehensive Analysis of Awareness in Contemporary TV Display Technologies

A display serves as a projecting mechanism that presents video content to the user through technologies such as cathode ray tube (CRT), liquid crystal display (LCD), light-emitting diode (LED), Organic light-emitting diode (OLED), or other projection methods. The global demand for intelligent displays has witnessed a substantial rise, primarily fueled by the increasing popularity of OLED-based devices and technology. Concurrently, the worldwide digital TV subscriptions surpassed one billion in 2017. In our investigation, we aimed to assess the awareness levels among individuals in both rural and urban areas regarding TV display technology. The findings reveal that approximately 79% of urban residents and 44% of rural inhabitants utilize a TV display compatible with their TV subscription. &nbsp