Synthesis of 3-(3-(Phenacyl/Alkyl/Benzylthio)-[1,2,4]Triazolo[3,4-B][1,3,4]Thiadiazol-6-Yl)-2<i>H</i>-Chromen-2-Ones

<div><p></p><p>Reaction of coumarin-3-carboxylic acid with 3,5-di mercapto-4-amino-s-triazole in POCl₃to generate 3-(3-mercapto-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)-2H-chromen-2-one (<b>3</b>). Reaction of <b>3</b> with different substituted phenacyl/benzyl/allyl bromides in anhydrous ethanol gave corresponding 3-(3-(phenacyl/alkyl/benzylthio)-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazol-6-yl)-2H-chromen-2-ones <b>5</b>. The structures of newly prepared compounds were confirmed by their analytic and spectral data.</p> </div

One-pot synthesis of bis (phenylimino dihydro thiazolyl-2<i>H</i>-chromene) derivatives

<p>A novel series of bis (phenylimino dihydro thiazolyl-2<i>H</i>-chromene) derivatives have been synthesized through an efficient one-pot multicomponent approach involving different substituted of 3-(2-bromoacetyl)-2<i>H</i>-chromen-2-ones, phenyl isothiocyanates and <i>para</i>-phenylenediamine in presence of dimethylformamide solvent. The target compounds were obtained in a shorter reaction time through simple reaction work up with good yields. All the synthesized products were characterized by their spectral and analytical data like IR, ¹H NMR, ¹³C NMR, Roesy, and mass spectral data.</p

Novel multicomponent synthesis of 2-OXO-1, 2-diphenylethylidene hydrazinyl thiadiazinyl-2<i>H</i>-chromen-2-one derivatives

<p></p> <p>A series of novel 2-oxo-1,2-diphenylethylidene hydrazinyl thiadiazinyl-2<i>H</i>-chromen-2-ones (shown in <a href="#c0001" target="_blank">Scheme 1</a>) have been synthesized via multicomponent approach by the reaction of equimolar amount of benzil (1), thiocarobohydrazide (2), and substituted of 3-(2-bromoacetyl)-2<i>H</i>-chromen-2-ones (3a-i) in a shorter reaction time with good yields. All these compounds were characterized by their spectral and analytical data like IR, ¹H NMR, ¹³C NMR, and mass spectra.</p

Bis coumarinyl bis triazolothiadiazinyl ethane derivatives: Synthesis, antiviral activity evaluation, and molecular docking studies

© 2018 Taylor & Francis. A series of novel 3,3′-(3,3′-(dihydroxy/hydroxyethane-1,2-diyl)bis(7H-[1,2,4]triazolo[3,4-b]triazolo[3,4-b[1,3,4]thiadiazine-6,3-diyl))bis(2H-chromen-2-ones) were prepared by the condensation of thiocarbohydrazide with tartaric acid or malic acid followed by various 3-(2-bromoacetyl)-2H-chromen-2-ones in two steps with good yields. All the synthesized compounds were characterized by analytical and spectral (IR, 1H NMR, 13C NMR, and mass) data. These synthesized bis(triazolothiadiazinyl coumarin) compounds were evaluated for broad spectrum of antiviral activity. Among all the tested compounds, compound 5f exhibited antiviral activity against H1N1 virus. The molecular docking studies of these compounds against H1N1 neuraminidase enzyme were performed. The binding affinity and binding values were compared with standard drugs.status: publishe

Bis coumarinyl bis triazolothiadiazinyl ethane derivatives: Synthesis, antiviral activity evaluation, and molecular docking studies

<p>A series of novel 3,3′-(3,3′-(dihydroxy/hydroxyethane-1,2-diyl)bis(7<i>H</i>-[1,2,4]triazolo[3,4-<i>b</i>][1,3,4]thiadiazine-6,3-diyl))bis(2<i>H</i>-chromen-2-ones) were prepared by the condensation of thiocarbohydrazide with tartaric acid or malic acid followed by various 3-(2-bromoacetyl)-2<i>H</i>-chromen-2-ones in two steps with good yields. All the synthesized compounds were characterized by analytical and spectral (IR, ¹H NMR, ¹³C NMR, and mass) data. These synthesized bis(triazolothiadiazinyl coumarin) compounds were evaluated for broad spectrum of antiviral activity. Among all the tested compounds, compound <b>5f</b> exhibited antiviral activity against H1N1 virus. The molecular docking studies of these compounds against H1N1 neuraminidase enzyme were performed. The binding affinity and binding values were compared with standard drugs.</p