22 research outputs found
The effects of weather conditions on the health of people living in urban and rural environments
Meteorology is an essential part of people's lives. Its influence on every aspect of human life is vast and especially connected to the well-being of an individual. The objective of this paper is to ascertain how meteorologic changes influence the health of people who live in urban and rural environments. The testing was carried out on a sample of 130 respondents. The respondents are of different sex, age and come from various environments. This research was conducted via an anonymous questionnaire. The results point to the fact that meteorological changes affect the health and well-being of both healthy and ill individuals, whether they live in urban or rural environments. The significance of this paper is reflected in the acquiring of data that can be used in medicine as well as health tourism.Publishe
Factors Influencing Dental Fear in Students of Biomedicine
Background: Dental fear is a reaction of an individual to actual or potential painful/harmful procedures in dental practice. There is large variation in reports of dental fear prevalence among university students, implying existence of different factors that influence occurrence of dental fear in various populations. Objective: The aim of the study was to investigate putative factors that may influence extent of dental fear among university students of biomedicine. Methods: This study was designed as cross-sectional investigation. In total, 113 students on study courses on the 3rd, 4th, 5th year of dentistry, and on the 4th, 5th and 6th year of medicine undergraduate program were surveyed at the Faculty of Medical Sciences, University of Kragujevac, Serbia. Fear of dentist was measured by the Dental Fear Survey and other variables were generated by questionnaire with questions about socio-demographic characteristics of the participants. Results: Students of biomedicine surveyed in this study did not suffer from dental fear in great extent (median value on the scale was close to the lower limit: 29.5. The only factor that increased risk for developing dental fear in our study was previous traumatic experience with a dentist. Conclusion: Dental fear is not very prevalent among biomedical students. However, main risk factor for dental fear in general population, previous traumatic experience with a dental intervention, also remains primary risk factor in population of biomedical students
Π‘ΠΈΠ½ΡΠ΅Π·Π° ΠΈ Π±ΠΈΠΎΠ»ΠΎΡΠΊΠ° Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡ Π°Π»ΠΊΠΈΠ»ΡΠΈΠΎ ΠΈ Π°ΡΠΈΠ»ΡΠΈΠΎ Π΄Π΅ΡΠΈΠ²Π°ΡΠ° ΡΠ΅ΡΡ-Π±ΡΡΠΈΠ»Ρ ΠΈΠ½ΠΎΠ½Π°
Biological activity of 2-tert-butyl-1,4-benzoquinone (TBQ) and its derivatives, 2-tert-butyl-5-(2-propylthio)-1,4-benzoquinone, 2-tert-butyl-5- -(propylthio)-1,4-benzoquinone, 2-tert-butyl-5,6-(ethylenedithio)-1,4-benzoquinone, 2-tert-butyl-5-(phenylthio)-1,4-benzoquinone and 2-tert-butyl-6-(phenylthio)- 1,4-benzoquinone, were tested for their antioxidant, antibacterial, toxic, cytotoxic and genotoxic potential. Using the DPPH test, all derivatives showed good antioxidant activity, better than ascorbic acid, and the 2-tert- -butyl-5-(propylthio)-1,4-benzoquinone derivative showed the strongest effect. Better antibacterial potential was observed against Gram-positive bacteria in the broth microdilution method in which the 2-tert-butyl-5-(phenylthio)-1,4- -benzoquinone derivative showed the strongest activity (MIC = 15.6 ΞΌM). The results of toxicity tests, using the Brine shrimp test, indicated that the derivatives lose their toxic potential compared to TBQ, except for 2-tert-butyl-6- -(phenylthio)-1,4-benzoquinone, which showed a 3 times stronger effect. Cytotoxicity was assessed by the MTT assay in 24 and 72 h treatments in MRC-5, HS 294T and A549 cell lines in threefold decreasing gradient (11, 33 and 100 ΞΌM). Modifications potentiate the cytotoxic effect, and the strongest effect was observed with the 2-tert-butyl-5,6-(ethylendithio)-1,4-benzoquinone derivative. In addition, the genotoxic potential was examined in the MRC-5 cell line using the comet assay. All tested derivatives of TBQ showed a genotoxic effect at all applied subtoxic concentrations. In general, the chemical modifications of TBQ enhanced its biological activity.ΠΡΠΏΠΈΡΠ°Π½Π° ΡΠ΅ Π±ΠΈΠΎΠ»ΠΎΡΠΊΠ° Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡ 2-ΡΠ΅ΡΡ-Π±ΡΡΠΈΠ»-1,4-Π±Π΅Π½Π·ΠΎΡ
ΠΈΠ½ΠΎΠ½Π° (TBQ) ΠΈ ΡΠ΅Π³ΠΎΠ²ΠΈΡ
Π΄Π΅ΡΠΈΠ²Π°ΡΠ°: 2-ΡΠ΅ΡΡ-Π±ΡΡΠΈΠ»-5-(ΠΈΠ·ΠΎΠΏΡΠΎΠΏΠΈΠ»ΡΠΈΠΎ)-1,4-Π±Π΅Π½Π·ΠΎΡ
ΠΈΠ½ΠΎΠ½Π°, 2-ΡΠ΅ΡΡ-Π±ΡΡΠΈΠ»-5-(ΠΏΡΠΎΠΏΠΈΠ»ΡΠΈΠΎ)-1,4-Π±Π΅Π½Π·ΠΎΡ
ΠΈΠ½ΠΎΠ½Π°, 2-ΡΠ΅ΡΡ-Π±ΡΡΠΈΠ»-5,6-(Π΅ΡΠΈΠ»Π΅Π½Π΅Π΄ΠΈΡΠΈΠΎ)-1,4-Π±Π΅Π½Π·ΠΎΡ
ΠΈΠ½ΠΎΠ½Π°, 2-ΡΠ΅ΡΡ-Π±ΡΡΠΈΠ»- -5-(ΡΠ΅Π½ΠΈΠ»ΡΠΈΠΎ)-1,4-Π±Π΅Π½Π·ΠΎΡ
ΠΈΠ½ΠΎΠ½Π° ΠΈ 2-ΡΠ΅ΡΡ-Π±ΡΡΠΈΠ»-6-(ΡΠ΅Π½ΠΈΠ»ΡΠΈΠΎ)-1,4-Π±Π΅Π½Π·ΠΎΡ
ΠΈΠ½ΠΎΠ½Π° ΡΠΊΡΡΡΡΡΡΡΠΈ ΡΠΈΡ
ΠΎΠ² Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°ΡΠΈΠ²Π½ΠΈ, Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΠΈΡΡΠΊΠΈ, ΡΠΎΠΊΡΠΈΡΠ½ΠΈ, ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΈ ΠΈ Π³Π΅Π½ΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΈ ΠΏΠΎΡΠ΅Π½ΡΠΈΡΠ°Π». ΠΡΠΈΠΌΠ΅Π½ΠΎΠΌ DPPH ΡΠ΅ΡΡΠ°, ΡΠ²ΠΈ Π΄Π΅ΡΠΈΠ²Π°ΡΠΈ ΡΡ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ Π΄ΠΎΠ±ΡΡ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°ΡΠΈΠ²Π½Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡ, Π±ΠΎΡΡ ΠΎΠ΄ Π°ΡΠΊΠΎΡΠ±ΠΈΠ½ΡΠΊΠ΅ ΠΊΠΈΡΠ΅Π»ΠΈΠ½Π΅, Π° Π½Π°ΡΡΠ°ΡΠ΅ Π΄Π΅ΡΡΡΠ²ΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΠΎ ΡΠ΅ Π΄Π΅ΡΠΈΠ²Π°Ρ 2-ΡΠ΅ΡΡ-Π±ΡΡΠΈΠ»-5-(ΠΏΡΠΎΠΏΠΈΠ»ΡΠΈΠΎ)-1,4-Π±Π΅Π½Π·ΠΎΡ
ΠΈΠ½ΠΎΠ½. ΠΠΎΡΠΈ Π°Π½ΡΠΈΠΌΠΈΠΊΡΠΎΠ±Π½ΠΈ ΠΏΠΎΡΠ΅Π½ΡΠΈΡΠ°Π» ΡΠ΅ ΠΏΡΠΈΠΌΠ΅ΡΠ΅Π½ ΠΏΡΠΎΡΠΈΠ² ΠΡΠ°ΠΌ-ΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΠΈΡ
Π±Π°ΠΊΡΠ΅ΡΠΈΡΠ° ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΌΠΈΠΊΡΠΎΠ΄ΠΈΠ»ΡΡΠΈΡΠ΅ Ρ Π±ΡΡΠΎΠ½Ρ, Π³Π΄Π΅ ΡΠ΅ Π΄Π΅ΡΠΈΠ²Π°Ρ 2-ΡΠ΅ΡΡ-Π±ΡΡΠΈΠ»-5-(ΡΠ΅Π½ΠΈΠ»ΡΠΈΠΎ)-1,4-Π±Π΅Π½Π·ΠΎΡ
ΠΈΠ½ΠΎΠ½ ΠΏΠΎΠΊΠ°Π·Π°ΠΎ Π½Π°ΡΡΠ°ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡ (MIC = 15,6 ΞΌΠ). Π Π΅Π·ΡΠ»ΡΠ°ΡΠΈ ΠΈΡΠΏΠΈΡΠΈΠ²Π°ΡΠ° ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΠΈ, ΠΏΡΠΈΠΌΠ΅Π½ΠΎΠΌ ΡΠ΅ΡΡΠ° Π½Π° Artemia salina, ΠΏΠΎΠΊΠ°Π·ΡΡΡ Π΄Π° Π΄Π΅ΡΠΈΠ²Π°ΡΠΈ Π³ΡΠ±Π΅ ΡΠΎΠΊΡΠΈΡΠ½ΠΈ ΠΏΠΎΡΠ΅Π½ΡΠΈΡΠ°Π» Ρ ΠΎΠ΄Π½ΠΎΡΡ Π½Π° TBQ, ΠΎΡΠΈΠΌ 2-ΡΠ΅ΡΡ-Π±ΡΡΠΈΠ»-6-(ΡΠ΅Π½ΠΈΠ»ΡΠΈΠΎ)- -1,4-Π±Π΅Π½Π·ΠΎΡ
ΠΈΠ½ΠΎΠ½Π°, ΠΊΠΎΡΠΈ ΡΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΠΎ 3 ΠΏΡΡΠ° ΡΠ°ΡΠΈ Π΅ΡΠ΅ΠΊΠ°Ρ. Π¦ΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡ ΡΠ΅ ΠΈΡΠΏΠΈΡΠ°Π½Π° ΠΠ’Π’ ΡΠ΅ΡΡΠΎΠΌ Ρ ΡΡΠ΅ΡΠΌΠ°Π½ΠΈΠΌΠ° ΠΎΠ΄ 24 ΠΈ 72 h Π½Π° ΡΠ΅Π»ΠΈΡΡΠΊΠΈΠΌ Π»ΠΈΠ½ΠΈΡΠ°ΠΌΠ° MRC-5, HS 294T ΠΈ A549 Ρ ΡΡΠΎΡΡΡΡΠΊΠΎ ΠΎΠΏΠ°Π΄Π°ΡΡΡΠ΅ΠΌ Π³ΡΠ°Π΄ΠΈΡΠ΅Π½ΡΡ (11, 33 ΠΈ 100 ΞΌΠ). ΠΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΡΠ΅ ΠΏΠΎΡΠ°ΡΠ°Π²Π°ΡΡ ΡΠΈΡΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΈ Π΅ΡΠ΅ΠΊΠ°Ρ, Π° Π½Π°ΡΡΠ°ΡΠΈ Π΅ΡΠ΅ΠΊΠ°Ρ ΡΠ΅ ΠΏΡΠΈΠΌΠ΅ΡΠ΅Π½ ΠΊΠΎΠ΄ Π΄Π΅ΡΠΈΠ²Π°ΡΠ° 2-ΡΠ΅ΡΡ-Π±ΡΡΠΈΠ»-5,6-(Π΅ΡΠΈΠ»Π΅Π½Π΄ΠΈΡΠΈΠΎ)-1,4-Π±Π΅Π½Π·ΠΎΡ
ΠΈΠ½ΠΎΠ½Π°. ΠΠΎΡΠ΅Π΄ ΡΠΎΠ³Π°, Π³Π΅Π½ΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΈ ΠΏΠΎΡΠ΅Π½ΡΠΈΡΠ°Π» ΡΠ΅ ΠΈΡΠΏΠΈΡΠ°Π½ Π½Π° ΡΠ΅Π»ΠΈΡΡΠΊΠΎΡ Π»ΠΈΠ½ΠΈΡΠΈ MRC-5 ΠΊΠΎΠΌΠ΅Ρ ΡΠ΅ΡΡΠΎΠΌ. Π‘Π²ΠΈ ΠΈΡΠΏΠΈΡΠΈΠ²Π°Π½ΠΈ Π΄Π΅ΡΠΈΠ²Π°ΡΠΈ ΡΡ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ Π³Π΅Π½ΠΎΡΠΎΠΊΡΠΈΡΠ½ΠΈ Π΅ΡΠ΅ΠΊΠ°Ρ ΠΏΡΠΈ ΡΠ²ΠΈΠΌ ΠΏΡΠΈΠΌΠ΅ΡΠ΅Π½ΠΈΠΌ ΡΡΠ±ΡΠΎΠΊΡΠΈΡΠ½ΠΈΠΌ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡΠ°ΠΌΠ°. ΠΠ΅Π½Π΅ΡΠ°Π»Π½ΠΎ, Ρ
Π΅ΠΌΠΈΡΡΠΊΠ΅ ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΡΠ΅ ΠΏΠΎΠ±ΠΎΡΡΠ°Π²Π°ΡΡ Π±ΠΈΠΎΠ»ΠΎΡΠΊΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡ 2-ΡΠ΅ΡΡ-Π±ΡΡΠΈΠ»-1,4-Π±Π΅Π½Π·ΠΎΡ
ΠΈΠ½ΠΎΠ½Π°
IMPROVEMENTS IN WOOD THERMOPLASTIC MATRIX COMPOSITE MATERIALS PROPERTIES BY PHYSICAL AND CHEMICAL TREATMENTS
This paper presents a short overview of the developments made in the field of wood thermoplastic composites in terms of surface treatment, flammability, matrix/reinforcement model, properties and application of recycled polymer matrices. The usage of lignocellulosic fibers as reinforcement in composite materials demands well formed interface between the fiber and the matrix. Because of the different nature of reinforcement and matrix components some physical and chemical treatment methods which improve the fiber matrix adhesion were introduced, as well as the improvements of lignocellulosic fibers and thermoplastic polymer matrix based composites flammability characteristics. These physical and chemical treatments influence the hydrophilic character of the lignocellulosic fibers, and therefore change their physical and mechanical properties
Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats
This study was conducted to investigate whether agmatine (AGM) provides
protection against oxidative stress induced by treatment with
chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive
oxygen species and efficiency of antioxidant protection in the brain
homogenates of forebrain cortexes prepared 48 h after treatment were
investigated. Chlorpromazine was applied intraperitoneally (i.p.) in
single dose of 38.7 mg/kg body weight (BW) The second group was treated
with both CPZ and AGM (75 mg/kg BW). The control group was treated with
0.9\% saline solution in the same manner. All tested compounds were
administered i.p. in a single dose. Rats were sacrificed by decapitation
48 h after treatment Treatment with AGM significantly attenuated the
oxidative stress parameters and restored antioxidant capacity in the
forebrain cortex. The data indicated that i.p. administered AGM exerted
antioxidant action in CPZ-treated animals. Moreover, reactive astrocytes
and microglia may contribute to secondary nerve-cell damage and
participate in the balance of destructive vs. protective actions
involved in the pathogenesis after poisoning.Ministry of Education, Science and Technological Development of the
Republic of Serbia {[}III41014]; Military Medical Academy
{[}MBMA/3/13-15, MBMA/6/15-17
The influence of BCL2, BAX, and ABCB1 gene expression on prognosis of adult de novo acute myeloid leukemia with normal karyotype patients
Deregulation of the apoptotic process underlies the pathogenesis of many cancers, including leukemia, but is also very important for the success of chemotherapy treatment. Therefore, the gene expression profile of main apoptotic factors, such as anti-apoptotic BCL2 (B-cell lymphoma protein 2) and pro-apoptotic BAX (BCL2-associated X), as well as genes involved in the multi-drug resistance (ABCB1), could have significant impact on the prognosis and could be used as targets for specific therapy
Somatic mutations of isocitrate dehydrogenases 1 and 2 are prognostic and follow-up markers in patients with acute myeloid leukaemia with normal karyotype
Mutations in the isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) genes are frequent molecular lesions in acute myeloid leukaemia with normal karyotype (AML-NK). The effects of IDH mutations on clinical features and treatment outcome in AML-NK have been widely investigated, but only a few studies monitored these mutations during follow-up
Probable Bruxism and Psychological Issues among Dental Students in Serbia during the COVID-19 Pandemic
The COVID-19 pandemic has drastically changed the routine way of life, having consequences in many segments of life, including dental practice and education. The aim of this study was to evaluate the frequency of probable bruxism in a sample of dental students in Serbia and to estimate the potential association between psychological factors related to the COVID-19 pandemic and the presence of bruxism. A cross-sectional study included 178 dental students in Serbia, who were interviewed using a specially-designed self-administered online questionnaire, which consisted of three sections, and after that, a clinical examination for the presence of bruxism symptoms in the oral cavity. Psychological status was evaluated using the Depression, Anxiety and Stress Scale-21 (DASS-21) and the Fear of COVID-19 Scale (FCV-19S). Saliva samples were taken to analyze salivary cortisol levels. The prevalence of probable bruxism was 34.8%. Respondents with probable bruxism had significantly higher DASS-21 and FCV-19S scores and mean values of salivary cortisol compared to non-bruxers. A history of COVID-19 infection, high stress, and fear of COVID-19 scores were associated with the presence of probable bruxism. The findings suggest that the COVID-19 pandemic has had a great psychological impact and impact on the presence and worsening of bruxism symptoms in a sample of dental students in Serbia