VENOUS THROMBOEMBOLISM (VTE) OUGHT TO BE DIVIDED INTO DEEP VEIN THROMBOSIS (DVT) AND PULMONARY THROMBOEMBOLISM (PTE), NOT PULMONARY EMBOLISM (PE)

Venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary thromboembolism (PTE), represents a significant healthcare burden worldwide. Different aspects of clinical conditions underlying different types of embolization are discussed in order to overcome the controversy over current names for these conditions. Therefore, we suggest that venous thromboembolism (VTE) ought to be divided into deep vein thrombosis (DVT) and pulmonary thromboembolism (PTE), not pulmonary embolism (PE)

A SUGGESTION FOR PROACTIVE CARDIOLOGIC APPROACH TO CUSHING’S SYNDROME OR DISEASE

Numerous studies and reviews agree about the increased cardiovascular risk in Cushing’s syn-drome. Therefore, the aim of the paper is to suggest a few common diagnostic and therapeutic cardiologic preferences for the majority of Cushing’s syndrome/Cushing’s disease (CS/CD) pa-tients which are not yet routine but have the rationale to become standard procedures. This may serve as an initial working document, to be improved by the experts in the field. A narrative review is used to present synthesis and deduction of several approaches in cardiology regarding the actu-al topic. Results are systematized as the risk factors or co-morbidities list (prevalent in CS/CD) coupled with current and adapted cardiologic suggestions for practice

Epidemija pandemijskog gripa H1N1 u Vojnoj gimnaziji

Background/Aim. The first cases of the pandemic pH1N1 influenza virus infection was observed in the United States and Mexico in April 2009 and the first laboratory confirmed case in Serbia was registered in June 2009. The aim of this paper was to report on the investigation of the first confirmed outbreak of the 2009 pandemic H1N1 influenza in Serbia and to describe the clinical and epidemiologic findings from this investigation. Methods. Descriptive and analytical epidemiological methods were used. Data were collected from medical records of the Military School students and epidemiological questionnaire. Pandemic H1N1 infection was initially confirmed by the RT-PCR assay in nasopharyngeal and oropharyngeal swabs and subsequently by the complement fixation test in serum samples. Results. The attack rate of acute respiratory illness was 70.8% (204/288). Pandemic H1N1 virus infection was confirmed in 44 of 82 tested cases of acute respiratory illness (53.7%) The most common clinical manifestations of pandemic influenza H1N1 were fever (88.6%), cough (61.4%), malaise (38.6%), runny nose (36.4%), headache (29.6%), sore throat (20.5%) and muscle pain (15.9%). Conclusion. The findings from this investigation suggest that pandemic H1N1 influenza in a high military school was widespread but did not cause severe illness.Uvod/Cilj. Prvi slučajevi pandemijske infekcije virusom influence pH1N1 ustanovljeni su u Americi i Meksiku u aprilu 2009. a u Srbiji prvi laboratorijski potvrđen slučaj registrovan je u junu 2009. godine. Cilj rada bio je da se prikaže istraživanje prve dokazane epidemije pandemijske influence H1N1 u Srbiji i opišu klinički i epidemiološki nalazi iz ovog istraživanja. Metode. Primenjen je deskriptivni i analitički epidemiološki metod. Izvor podataka bila je medicinska dokumentacija učenika Vojne gimnazije i epidemiološki upitnik. Infekcija pandemijskim virusom H1N1 prvo je dokazana pomoću RT-PCR u nazofaringealnim i orofaringealnim brisevima, a zatim i reakcijom vezivanja komlementa u uzorcima seruma. Rezultati. Stopa javljanja akutnog respiratornog oboljenja iznosila je 70.8% (204/288). Infekcija pandemijskim H1N1 virusom potvrđena je kod 44 od 82 testiranih slučajeva akutnog respiratornog oboljenja (53,7%). Najčešće kliničke manifestacije pandemijske influence H1N1 bile su povišena temperatura (88,6%), kašalj (61,4%), malaksalost (38,6%), rinitis (36,4%), glavobolja (29,6%), gušobolja (20,5%) i bol u mišićima (15,9%). Zaključak. Rezultati ovog istraživanja ukazuju da je pandemijska influenca H1N1 bila raširena u Vojnoj gimnaziji, ali da nije izazvala teške forme oboljenja

The synthesis, characterization, behavior in the Briggs-Rauscher reaction, and photoluminescence properties of newly created phosphate-tungsten bronzed doped with cerium and praseodymium

Phosphate tungsten bronzes (PWBs), due to their intriguing and potentially valuable properties, have consistently garnered research attention [1]. In this study, we introduced two rare-earth metallic elements, namely cerium and praseodymium, as dopants for PWBs. This led to the successful synthesis of novel PWBs doped with cerium and praseodymium, which were subsequently subjected to various characterization techniques, including thermal analyses (TA), Fourier-transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRPD), scanning electron microscopy with energy-dispersive X-ray spectrometry (SEM-EDX), and hotoluminescence spectroscopy (PL). The behavior of cerium and praseodymium doped phosphate tungsten bronzes (Ce-PWB and Pr-PWB) [2], was investigated in the Briggs-Rauscher (BR) oscillatory reaction. The alterations in the oscillatory dynamics, brought about by the incorporation of cerium and praseodymium dopants, served as a means to distinguish between these bronzes. Additionally, this approach provided a method for assessing the catalytic properties of the bronzes. Apart from their nonlinear behavior, these bronzes also exhibited photoluminescence in the visible spectrum, specifically in the blue region

Impact of the COVID-19 Pandemic on Melanoma Diagnosis: Increased Breslow Thickness in Primary Melanomas: A Single Center Experience

Early melanoma diagnosis plays a key role in ensuring best prognosis with good survival rates. The ongoing global COVID-19 pandemic has greatly impacted global and national healthcare systems, thus making it a real challenge. The aim of this study was to evaluate the impact of the pandemic on diagnostic delay in melanoma patients in Serbia. In this retrospective study, we included patients treated at the university hospital in Serbia’s capitol over a period of five years and three months. We compared the prepandemic (01/JAN/17-14/MAR/20) and pandemic periods (15/MAR/20-31/MAR/22) by evaluating patient demographic data, melanoma subtype, Breslow thickness, Clark level, ulceration status, mitotic index rate and pT staging. We observed a significant reduction in the number of diagnosed patients (86.3 vs. 13.7%; p = 0.036), with melanomas having an increased median Breslow thickness (1.80 vs. 3.00; p = 0.010), a higher percentage of Clark IV–V level lesions (44.0% vs. 63.0%; p = 0.009), an increase in median mitotic index rate (2 vs. 5; p < 0.001) and a trend of increase in lesions thicker than 2 mm (37.8% vs. 53.7%; p = 0.026). We believe that this study can be a useful scenario guide for future similar events, highlighting the importance of preventive measures and timely diagnosis for the best patient outcomes

Železničko-drumski most u Novom Sadu - racionalnost konstrukcije mosta

The construction of Railway Road Bridge across the Danube in Novi Sad is in progress. The bridge is designed for two railway tracks, two road lanes and two footpaths, with total width of 31,440 m. The distances of the piers are 27+178,5+220,5+48 m and total bridge length is 474 m. On the cetral two spans are steel tied arches with network hangers and composite decks. In the article is presented the rationality of the bridge structure – main bearing systems, hangers and deck structures – according to steel material quantities and total construction costs.Železničko-drumski most preko Dunava u Novom Sadu je u toku gradnje. Most ima dva koloseka, dve drumske trake i dve pešačke staze i širok je 31,440 m. Razmaci stubova su 27+178,5+220,5+ 48 m, pa je ukupna dužina mosta 474 m. Na dva centralna raspona su čelični lukovi sa zategom, dijagonalnim vešaljkama i spregnutom kolovoznom konstrukcijom. Konstrukcija mosta (glavni noseći sistemi, vešaljke i kolovozne konstrukcije) je vrlo racionalna po količini materijala i koštanju izgradnje

Comparison of the luminescence properties of phosphate-tungsten bronze and cerium doped phosphate-tungsten bronze

Phosphate-tungsten bronzes (PWBs) constantly attract a lot of attention owing to their interesting chemical, mechanical, and optical properties. Furthermore, tungsten bronzes as inert inorganic solids, exhibit interesting and useful electronic properties when rare-earth ions are incorporated into their structure. Cerium doped phosphate-tungsten bronze (Ce-PWB) is obtained in the process of phase transformations of CePW12O40×6H2O (Ce-PWA) salt. The brown crystals of Ce-PWB are formed after heating of Ce-PWA in a furnace, in a temperature range from room temperature to 650 °C. In the present paper the luminescence properties of undoped PWB and Ce-PWB are analyzed and compared. Regarding the characterized luminescence properties of PWB and Ce-PWB, only PWB matrix showed luminescence, while dopant Ce3+ had no significant influence on the change of the emission spectra with characteristic spectra for this ion. The obtained CIE chromaticity diagrams showed that both samples emit in the deep blue region, suggesting their possible use as a blue emitting source for white light-emitting diodes (LEDs)

Železničko-drumski most u Novom Sadu - Glavni projekat i izvođenje

Zbornik radova Građevinskog fakultet

Immunohistochemical analysis of cyclin A expression in Wilms tumor

Background: Cyclin A overexpression is found in a variety of human tumors and correlates with unfavorable outcome. We analyzed immunohistochemical expression of cyclin A in Wilms tumor (WT) in relation to clinicopathological characteristics, preoperative chemotherapy (PrOpChTh), and overall survival (OS). Methods: This retrospective study involved 43 patients who underwent nephrectomy from January 1996 to October 2010. Tumor stage and histological subtype were determined by revised Societé International d’Oncologie Pediatrique protocol, based on histological components/alterations caused by PrOpChTh, within the prognostic group of low, intermediate and high risk, and with criteria for anaplasia. The regressive/necrotic changes in total tumor mass of primary tumor and the proportion of epithelial, blastemal, and stromal components in the remaining viable tumor tissue were also determined. Cyclin A expression was evaluated by immunohistochemistry using a polyclonal rabbit, antihuman antibody (H-432). Results: Cyclin A overexpression was found in 34.3% of WTs, with higher frequency in tumors with epithelial (31.3%) and blastemal (37.1%) components than those with stromal component (17.7%). Regarding histological type, cyclin A overexpression was found most often in focal anaplasia (100%), stromal (60%), and diffuse anaplastic (66.7) WTs. The overexpression was also more frequent in stages 3 and 4 (77.8% and 66.7%, respectively) compared to tumors in stages 1 and 2 (13.3% and 12.5%, respectively; p = 0.004) in all components, as well as in blastemal component in stages 3 and 4 (77.8% and 66.7%, respectively) vs. stages 1 and 2 (13.3% and 25%, respectively, p = 0.009). Cyclin A overexpression in all components was 66.7% in WTs with metastasis and 31.3% in WTs without metastasis (p = 0.265, Fisher test). Log-rank testing revealed differences of OS regarding stage (p = 0.000), prognostic groups (p = 0.001), and cyclin A expression in blastemal component (p = 0.025). After univariate analysis, tumor stage (p = 0.001), prognostic group (p = 0.004), and cyclin A expression in blastemal component (p = 0.042) were significant prognostic factors for OS; however, after multivariate analysis, none of these factors were confirmed as independent predictors of survival. Discussion: This study showed that cyclin A overexpression might be associated with the development and progression of WT with anaplasia. Also, cyclin A overexpression was more often observed in advanced stages (3 and 4) of WT, in the group of high-risk WTs, and in focal and diffuse anaplasia WTs. There was no relation of cyclin A overexpression and metastatic ability of WT. Although this study has not confirmed the prognostic value of cyclin A overexpression, its association with unfavorable prognosis should be further evaluated. Copyright 2019 Radojevic-Škodric et al

Upper limb replantation: Surgical strategy and the prophylaxis of acute renal failure due to ischemia reperfusion injury – A report of two cases

Introduction. The arm replantation is an extremely rare and challenging procedure. The recognized risk is myoglobinuria and, consenquently, ischemia reperfusion-induced renal failure. Case report. We presented two patients aged 24 and 46 years who were admitted after traumatic arm amputation. Ischemia time was six and two hours, respectively. Postoperative intensive care treatment with assisted ventilation, sedation, and obtaining sufficient urine output prevented myoglobin-induced renal injury. In the case where ischemia time was shorter, there was only one delayed reconstruction of skin defects after fasciotomy, but in the case where ischemia lasted longer, the patient had two secondary look procedures with acceptable definitive results. Conclusion. Arm replantation is a safe procedure even in cases with longer ischemia time. Postoperative control of urine output, correction of acidosis, and preventing myoglobin-induced tubular injury are crucial for stable postoperative recovery and