Tempering and enabling ambition: how equity is considered in domestic processes preparing NDCs

The considerations of how Nationally Determined Contributions (NDCs) to global climate action under the Paris Agreement are ambitious and fair, or equitable, is expected to guide countries’ decisions with regards to the ambition and priorities of those contributions. This article investigates the equity aspect of the NDCs of four cases (Canada, the EU, Kenya, and South Africa) utilizing a combination of document analysis and expert interviews. It interrogates both the NDC documents themselves and, uniquely, the role of international and domestic equity considerations within the domestic policy processes that led to the formulation of the NDCs. For this, 30 participants and close observers of these processes were interviewed. We find countervailing effects of equity on ambition, with an enabling, or ambition-enhancing, effect resulting from international equity, in that these four Parties show willingness to do more if others do, too. In contrast, tempering effect appears to result from domestic equity concerns, for example with regards to real, perceived, or anticipated adverse distributional impacts of climate action across regions, sectors, and/or societal strata. Political cultures differ across the four case studies, as do the key actors that influence domestic policies and the preparations of NDCs. This paper also demonstrates that research on equity in NDCs can benefit from expanding its scope from the contents of NDC submissions to also examine the underlying decision-making processes, to generate insights that can contribute to future NDCs being both equitable and ambitious

Tempering and enabling ambition: how equity is considered in domestic processes preparing NDCs

The considerations of how Nationally Determined Contributions (NDCs) to global climate action under the Paris Agreement are ambitious and fair, or equitable, is expected to guide countries’ decisions with regards to the ambition and priorities of those contributions. This article investigates the equity aspect of the NDCs of four cases (Canada, the EU, Kenya, and South Africa) utilizing a combination of document analysis and expert interviews. It interrogates both the NDC documents themselves and, uniquely, the role of international and domestic equity considerations within the domestic policy processes that led to the formulation of the NDCs. For this, 30 participants and close observers of these processes were interviewed. We find countervailing effects of equity on ambition, with an enabling, or ambition-enhancing, effect resulting from international equity, in that these four Parties show willingness to do more if others do, too. In contrast, tempering effect appears to result from domestic equity concerns, for example with regards to real, perceived, or anticipated adverse distributional impacts of climate action across regions, sectors, and/or societal strata. Political cultures differ across the four case studies, as do the key actors that influence domestic policies and the preparations of NDCs. This paper also demonstrates that research on equity in NDCs can benefit from expanding its scope from the contents of NDC submissions to also examine the underlying decision-making processes, to generate insights that can contribute to future NDCs being both equitable and ambitious

Tempering and enabling ambition: how equity is considered in domestic processes preparing NDCs

The considerations of how Nationally Determined Contributions (NDCs) to global climate action under the Paris Agreement are ambitious and fair, or equitable, is expected to guide countries’ decisions with regards to the ambition and priorities of those contributions. This article investigates the equity aspect of the NDCs of four cases (Canada, the EU, Kenya, and South Africa) utilizing a combination of document analysis and expert interviews. It interrogates both the NDC documents themselves and, uniquely, the role of international and domestic equity considerations within the domestic policy processes that led to the formulation of the NDCs. For this, 30 participants and close observers of these processes were interviewed. We find countervailing effects of equity on ambition, with an enabling, or ambition-enhancing, effect resulting from international equity, in that these four Parties show willingness to do more if others do, too. In contrast, tempering effect appears to result from domestic equity concerns, for example with regards to real, perceived, or anticipated adverse distributional impacts of climate action across regions, sectors, and/or societal strata. Political cultures differ across the four case studies, as do the key actors that influence domestic policies and the preparations of NDCs. This paper also demonstrates that research on equity in NDCs can benefit from expanding its scope from the contents of NDC submissions to also examine the underlying decision-making processes, to generate insights that can contribute to future NDCs being both equitable and ambitious

Putative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes

Background. Guanine-rich nucleic acid sequences are capable of folding into an intramolecular four-stranded structure called a G-quadruplex. When found in gene promoter regions, G-quadruplexes can downregulate gene expression, possibly by blocking the transcriptional machinery. Here we have used a genome-wide bioinformatic approach to identify Putative G-Quadruplex Sequences (PQS) in the Plasmodium falciparum genome, along with biophysical techniques to examine the physiological stability of P. falciparum PQS in vitro. Results. We identified 63 PQS in the non-telomeric regions of the P. falciparum clone 3D7. Interestingly, 16 of these PQS occurred in the upstream region of a subset of the P. falciparum var genes (group B var genes). The var gene family encodes PfEMP1, the parasite’s major variant antigen and adhesin expressed at the surface of infected erythrocytes, that plays a key role in malaria pathogenesis and immune evasion. The ability of the PQS found in the upstream regions of group B var genes (UpsB-Q) to form stable Gquadruplex structures in vitro was confirmed using 1H NMR, circular dichroism, UV spectroscopy, and thermal denaturation experiments. Moreover, the synthetic compound BOQ1 that shows a higher affinity for DNA forming quadruplex rather than duplex structures was found to bind with high affinity to the UpsB-Q. Conclusions. This is the first demonstration of non-telomeric PQS in the genome of P. falciparum that form stable G-quadruplexes under physiological conditions in vitro. These results allow the generation of a novel hypothesis that the G-quadruplex sequences in the upstream regions of var genes have the potential to play a role in the transcriptional control of this major virulence-associated multi-gene family

Layer interdependence of transport in an undoped electron-hole bilayer

The layer interdependence of transport in an undoped electron-hole bilayer (uEHBL) device was studied as a function of carrier density, interlayer electric field, and temperature. The uEHBL device consisted of a density tunable, independently contacted two-dimensional electron gas (2DEG) and two-dimensional hole gas (2DHG) induced via field effect in distinct GaAs quantum wells separated by a 30 nm Al$_{0.9}$Ga$_{0.1}$As barrier. Transport measurements were made simultaneously on each layer using the van der Pauw method. An increase in 2DHG mobility with increasing 2DEG density was observed, while the 2DEG mobility showed negligible dependence on the 2DHG density. Decreasing the interlayer electric-field and thereby increasing interlayer separation also increased the 2DHG mobility with negligible effects on the 2DEG mobility. The change in interlayer separation as interlayer electric-field changed was estimated using 2DHG Coulomb drag measurements. The results were consistent with mobility of each layer being only indirectly dependent on the adjacent layer density and dominated by background impurity scattering. Temperature dependencies were also determined for the resistivity of each layer.Comment: 8 pages, 6 figures, submitted to Phys. Rev.

Multiscale structural control of linked metal–organic polyhedra gel by aging-induced linkage-reorganization

Assembly of permanently porous metal–organic polyhedra/cages (MOPs) with bifunctional linkers leads to soft supramolecular networks featuring both porosity and processability. However, the amorphous nature of such soft materials complicates their characterization and thus limits rational structural control. Here we demonstrate that aging is an effective strategy to control the hierarchical network of supramolecular gels, which are assembled from organic ligands as linkers and MOPs as junctions. Normally, the initial gel formation by rapid gelation leads to a kinetically trapped structure with low controllability. Through a controlled post-synthetic aging process, we show that it is possible to tune the network of the linked MOP gel over multiple length scales. This process allows control on the molecular-scale rearrangement of interlinking MOPs, mesoscale fusion of colloidal particles and macroscale densification of the whole colloidal network. In this work we elucidate the relationships between the gel properties, such as porosity and rheology, and their hierarchical structures, which suggest that porosity measurement of the dried gels can be used as a powerful tool to characterize the microscale structural transition of their corresponding gels. This aging strategy can be applied in other supramolecular polymer systems particularly containing kinetically controlled structures and shows an opportunity to engineer the structure and the permanent porosity of amorphous materials for further applications

The potential for domestic thermal insulation retrofits on the South African Highveld

The South African Highveld is a portion on the inland plateau characterized by low winter ambient temperatures. Studies done in several climatic regions around the world have found a positive relationship between inadequate housing and low indoor temperatures during the winter season. Prolonged exposure to low indoor temperature is a threat to human physical health. This study characterizes indoor human thermal comfort conditions in typical low-income residential dwellings during the winter season. Mapping indoor human thermal comfort can assist in exploring the potential for domestic thermal insulation retrofits interventions. In-situ temperature measurements were done in 2014, 2016 and 2017 across three Highveld settlements of kwaZamokuhle, kwaDela, and Jouberton. The sample included a mixture of old (pre-1994), post 1994 Reconstruction and Development Programme (RDP) as well as non-RDP structures. Findings were that 88% of sampled dwellings in Jouberton 2016, 86% in Jouberton 2017, 62% in kwaDela and 58% in kwaZamokuhle had daily mean temperatures below the WHO guideline of 18°C. These low indoor temperatures indicate poor insulation in these sampled dwellings. Across all settlements, insulated dwellings had higher daily mean indoor temperatures than non-insulated dwellings. These findings indicate the potential to use thermal insulation retrofits in improving indoor thermal conditions as the majority of dwellings are non-insulated thereby exposing occupants to low indoor temperatures

Invasive Fungal Infections in Patients with Hematologic Malignancies (Aurora Project): Lights and Shadows During 18-Months Surveillance

The aim of this multicenter prospective study was to evaluate the incidence of invasive fungal infections (IFIs) in adult and pediatric patients with hematologic malignancies, involving nine nosocomial facilities in Southern Italy over a period of 18 months. Furthermore, results of an environmental microbial surveillance routinely carried out in some of the enrolled hospitals are reported. A total of 589 onco-hematological patients were enrolled and 27 IFIs were documented. The main infections were caused by yeasts, more than filamentous fungi (overall incidence of 2.7% and 1.9%, respectively). The yeasts were mainly represented by Candida spp. (87.5%), all isolated by blood cultures; C. parapsilosis was the most common species. Among mould infections, the most frequent site was the lung, with regard to aspergillosis (81.8%). In six of the 10 patients with suspected aspergillosis, the diagnosis was made by the detection of galactomannan and (1,3)-β-d-glucan antigens. The microbiological surveillance carried out on 156 air, 312 water and 312 surface samples revealed low environmental contamination: Alternaria alternata was the only fungus isolated from two surface samples. Our data, especially the low occurrence of filamentous fungi, suggest a particular local epidemiology. Further studies are needed to confirm this microbiological trend in onco-hematological patients in Southern Italy, the results of which might be helpful to improve the management of these patients

Prior Stroke in PFO Patients Is Associated With Both PFO-Related and -Unrelated Factors.

Background and Purpose: To identify factors associated with prior stroke at presentation in patients with cryptogenic stroke (CS) and patent foramen ovale (PFO). Methods: We studied cross-sectional data from the International PFO Consortium Study (NCT00859885). Patients with first-ever stroke and those with prior stroke at baseline were analyzed for an association with PFO-related (right-to-left shunt at rest, atrial septal aneurysm, deep venous thrombosis, pulmonary embolism, and Valsalva maneuver) and PFO-unrelated factors (age, gender, BMI, hypertension, diabetes mellitus, hypercholesterolemia, smoking, migraine, coronary artery disease, aortic plaque). A multivariable analysis was used to adjust effect estimation for confounding, e.g., owing to the age-dependent definition of study groups in this cross-sectional study design. Results: We identified 635 patients with first-ever and 53 patients with prior stroke. Age, BMI, hypertension, diabetes mellitus, hypercholesterolemia, coronary artery disease, and right-to-left shunt (RLS) at rest were significantly associated with prior stroke. Using a pre-specified multivariable logistic regression model, age (Odds Ratio 1.06), BMI (OR 1.06), hypercholesterolemia (OR 1.90) and RLS at rest (OR 1.88) were strongly associated with prior stroke.Based on these factors, we developed a nomogram to illustrate the strength of the relation of individual factors to prior stroke. Conclusion: In patients with CS and PFO, the likelihood of prior stroke is associated with both, PFO-related and PFO-unrelated factors

Heart re-transplantation in Eurotransplant

Internationally 3% of the donor hearts are distributed to re-transplant patients. In Eurotransplant, only patients with a primary graft dysfunction (PGD) within 1 week after heart transplantation (HTX) are indicated for high urgency listing. The aim of this study is to provide evidence for the discussion on whether these patients should still be allocated with priority. All consecutive HTX performed in the period 1981-2015 were included. Multivariate Cox' model was built including: donor and recipient age and gender, ischaemia time, recipient diagnose, urgency status and era. The study population included 18 490 HTX, of these 463 (2.6%) were repeat transplants. The major indications for re-HTX were cardiac allograft vasculopathy (CAV) (50%), PGD (26%) and acute rejection (21%). In a multivariate model, compared with first HTX hazards ratio and 95% confidence interval for repeat HTX were 2.27 (1.83-2.82) for PGD, 2.24 (1.76-2.85) for acute rejection and 1.22 (1.00-1.48) for CAV (P < 0.0001). Outcome after cardiac re-HTX strongly depends on the indication for re-HTX with acceptable outcomes for CAV. In contrast, just 47.5% of all hearts transplanted in patients who were re-transplanted for PGD still functioned at 1-month post-transplant. Alternative options like VA-ECMO should be first offered before opting for acute re-transplantation