BIOMECHANICAL ANALYSIS OF SPINE MOVEMENTS IN HIKING ON SAILING: A PRELIMINARY STUDY

This study aimed to evaluate sailors’ vertebral spine movements and positioning during hiking position. One Laser Class sailor composed the sample. Four 60Hz Peak Motus System® cameras were used. To evaluate some spine angles the following points were chosen: in saggital plane - the neck flexion angle, thoracic kiphosis angle and lumbar lordosis angle; in frontal plane – the lateral inclination angle; in transversal plane – the trunk rotation. Data were analysed through descriptive statistics. The analysis shows great angle variations performed in a 10s hiking execution. It can be observed that the sailor’s trunk performs, in the three axes, a sum of movements during the technical gesture. It was demonstrated that hiking is not a static posture and to study this position researchers should not consider trunk as a fixed segment

Pharmacogenetics of Risperidone and Cardiovascular Risk in Children and Adolescents

Objective. To identify the frequency of obesity and metabolic complications in child and adolescent users of risperidone. Potential associations with clinical parameters and SNPs of the HTR2C, DRD2, LEP, LEPR, MC4R, and CYP2D6 genes were analyzed. Methods. Samples from 120 risperidone users (8–20 years old) were collected and SNPs were analyzed, alongside assessment of chronological and bone ages, prescribed and weight-adjusted doses, use of other psychotropic drugs, waist circumference, BMI z-scores, blood pressure, HOMA-IR index, fasting levels of serum glucose, insulin, cholesterol, triglycerides, transaminases, and leptin. Results. Thirty-two (26.7%) patients were overweight and 5 (4.2%) obese. Hypertension was recorded in 8 patients (6.7%), metabolic syndrome in 6 (5%), and increased waist circumference in 20 (16.7%). The HOMA-IR was high for 22 patients (18.3%), while total cholesterol and triglycerides were high in 20 (16.7%) and 41 (34.2%) patients, respectively. SNP associations were found for LEP, HTR2C, and CYP2D6 with BMI; CYP2D6 with blood pressure, ALT, and HOMA-IR; HTR2C and LEPR with leptin levels; MC4R and DRD2 with HOMA-IR; HTR2C with WC; and LEP with ALT. Conclusions. Although not higher than in the general pediatric population, a high frequency of patients was overweight/obese, with abnormalities in metabolic parameters and some pharmacogenetic associations

Os conceitos de estatística em atividades interdisciplinares

A abordagem da Matemática na Educação Básica, segundo as novas orientações curriculares, deve, entre outras metodologias, acontecer de forma interdisciplinar. Assim, este artigo é resultado de atividades interdisciplinares relacionadas aos conceitos de estatística envolvendo a elaboração e socialização de uma oficina ministrada aos professores do ensino fundamental, sendo, em sua maioria, docentes da educação básica das séries iniciais. A Abordagem do tema estatística oportunizou discutir com os professores a inserção dos primeiros conceitos relacionados ao tratamento da informação, bem como acompanhar a construção destes desde os anos iniciais. O conjunto de atividades desenvolvidas com os professores da Escola Estadual de Educação Básica Protásio Joaquim da Cunha envolveu os conceitos da Estatística. A escolha desta escola se deu por ser integrante do Programa Institucional de Bolsa de Iniciação à Docência (PIBID), juntamente com o Instituto Federal Catarinense (IFC) - Câmpus Avançado Sombrio, onde os bolsistas realizam suas atividades de iniciação docente. A oficina foi planejada a partir da problemática: Como abordar os conceitos da estatística desde os anos iniciais? Esta problemática, para ser respondida, envolve, entre outros objetivos, analisar, interpretar e descrever diversos fenômenos relacionados à estatística. Esta oficina foi a primeira intervenção realizada pelos bolsistas do projeto PIBID, orientados pelos professores supervisores, e seus resultados nos forneceram dados para a produção deste artigo, bem como o planejamento das próximas ações

Os conceitos da estatística aplicados a educação alimentar

A abordagem da Matemática na Educação Básica, segundo as novas orientações curriculares, deve, entre outras metodologias, acontecer de forma interdisciplinar. Assim, este relato é resultado de uma atividade interdisciplinar entre a Matemática, por meio dos conceitos da Estatística, com a Educação Alimentar. Abordando a Educação Alimentar, temos a oportunidade de discutir com os estudantes a importância de uma alimentação adequada, tornando-os consumidores mais críticos e atentos à composição dos alimentos, à propaganda, às datas de validade e às alternativas de alimentos mais saudáveis. Pensando em contribuir com o Ensino da Matemática, planejamos uma oficina intitulada “Os conceitos da Estatística aplicados à Educação Alimentar”, para ser ministrada aos professores da Escola Estadual de Educação Básica Protásio Joaquim da Cunha. A escolha desta escola se deu por ser ela uma das integrantes do Programa Institucional de Bolsa de Iniciação à Docência – PIBID. A escolha do tema permite-nos apresentar a seguinte problemática: Como abordar a Educação Alimentar a partir da preferência dos alimentos envolvendo os alunos da Educação Básica? Esta problemática, para ser respondida, envolve entre outros objetivos: analisar, interpretar e descrever diversos fenômenos relacionados à alimentação. A primeira atividade desta oficina refere-se à coleta e tratamento de dados no terceiro ano do ensino médio do Instituto Federal Catarinense – Campus Avançado Sombrio, envolvendo 28 alunos. O conceito de uma boa alimentação pode ser desenvolvido na escola desde os anos iniciais, envolvendo todas as disciplinas curriculares. Nesta perspectiva, incluímos o tratamento da informação como uma ferramenta para explorar os diferentes aspectos de uma boa alimentação. Entre os resultados esperados para esta atividade está a conscientização dos envolvidos sobre uma alimentação saudável, utilizando a ferramenta auxiliar da Estatística na interpretação, visualização e análise dos resultados

Hyperprolactinemia In Children And Adolescents With Use Of Risperidone: Clinical And Molecular Genetics Aspects.

In children and adolescents treated with risperidone, hyperprolactinemia is a frequent complication that may have clinical repercussions. Several genes have been associated with this occurrence. The aim of this study was to evaluate the frequency of hyperprolactinemia in children and adolescents treated with risperidone, and its associations with clinical and pharmacological data and certain polymorphisms of the following genes: Dopamine receptor D2 (DRD2), 5-hydroxytryptamine (serotonin) receptor 2C (HTR2C), cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), leptin (LEP), leptin receptor (LEPR), melanocortin 4 receptor (MC4R), and scavenger receptor class B, member 2 (SCARB2). The study included patients using risperidone (8-20 years old) and healthy subjects not exposed to the medication. Psychopathological symptoms, doses, and duration of treatment with risperidone, sex, skin color, body mass index (BMI), use of other psychotropic drugs, and polymorphisms of DRD2, HTR2C, CYP2D6, LEP, LEPR, MC4R, and SCARB2 genes were evaluated. There were 120 patients and 197 individuals not exposed to risperidone who were evaluated. Among patients, hyperprolactinemia was found in 79 (65.8%) cases, with no differences regarding sex, skin color, or being in monotherapy with risperidone (26.7% of total patients) or not. The level of prolactin was not correlated, either in case or control groups, with chronological age, bone age, prescribed dose of risperidone, weight-adjusted dose of risperidone, or BMI (p > 0.05), but was negatively correlated with the treatment duration (r = -0.352, p = 0.001 among cases; and r = -0.324, p = 0.039 among controls). There were significant differences in use of risperidone between patients and healthy subjects without the medication in the frequency of the polymorphisms of the DRD2, HTR2C, and LEP genes. Considering both sexes together and also specifically among females, the occurrence of hyperprolactinemia was higher in the presence of the C allele of the rs6318 single nucleotide polymorphisms (SNP) of the HTR2C gene. This group of children and adolescents with or without isolated use of risperidone presented with a high frequency of hyperprolactinemia, although asymptomatic, and associated, when considering only females or both sexes together, with being a carrier of the C allele of the rs6318 SNP of the HTR2C gene.25738-74

Hyperprolactinemia in children and adolescents with use of risperidone: clinical and molecular genetics aspects

In children and adolescents treated with risperidone, hyperprolactinemia is a frequent complication that may have clinical repercussions. Several genes have been associated with this occurrence. The aim of this study was to evaluate the frequency of hyperprolactinemia in children and adolescents treated with risperidone, and its associations with clinical and pharmacological data and certain polymorphisms of the following genes: Dopamine receptor D2 (DRD2), 5-hydroxytryptamine (serotonin) receptor 2C (HTR2C), cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6), leptin (LEP), leptin receptor (LEPR), melanocortin 4 receptor (MC4R), and scavenger receptor class B, member 2 (SCARB2). The study included patients using risperidone (8–20 years old) and healthy subjects not exposed to the medication. Psychopathological symptoms, doses, and duration of treatment with risperidone, sex, skin color, body mass index (BMI), use of other psychotropic drugs, and polymorphisms of DRD2, HTR2C, CYP2D6, LEP, LEPR, MC4R, and SCARB2 genes were evaluated. There were 120 patients and 197 individuals not exposed to risperidone who were evaluated. Among patients, hyperprolactinemia was found in 79 (65.8%) cases, with no differences regarding sex, skin color, or being in monotherapy with risperidone (26.7% of total patients) or not. The level of prolactin was not correlated, either in case or control groups, with chronological age, bone age, prescribed dose of risperidone, weight-adjusted dose of risperidone, or BMI (p > 0.05), but was negatively correlated with the treatment duration (r = –0.352, p = 0.001 among cases; and r = –0.324, p = 0.039 among controls). There were significant differences in use of risperidone between patients and healthy subjects without the medication in the frequency of the polymorphisms of the DRD2, HTR2C, and LEP genes. Considering both sexes together and also specifically among females, the occurrence of hyperprolactinemia was higher in the presence of the C allele of the rs6318 single nucleotide polymorphisms (SNP) of the HTR2C gene. This group of children and adolescents with or without isolated use of risperidone presented with a high frequency of hyperprolactinemia, although asymptomatic, and associated, when considering only females or both sexes together, with being a carrier of the C allele of the rs6318 SNP of the HTR2C gene251073874

Resumos concluídos - Bioquímica

Resumos concluídos - Bioquímic

Resumos concluídos - Bioquímica

Resumos concluídos - Bioquímic

Resumos concluídos - Bioquímica

Resumos concluídos - Bioquímic