10 research outputs found

    L'Écho : grand quotidien d'information du Centre Ouest

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    17 mai 19391939/05/17 (A68).Appartient à l’ensemble documentaire : PoitouCh

    LOS DOLORES IDIOPÁTICOS Y LOS HORARIOS DE LO IMPREDECIBLE: MODELO ANIMAL

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    Dicha presentación hace una exposición de los experimentos pertinentes a las investigaciones financiadaspor la Vicerectoría de Investigación y presentadas a través de la Escuela de Psicología encolaboración cercana con La Facultad de Farmacia. Dichas investigaciones buscan indagar sobre losefectos del estrés crónico y agudo en los niveles de analgesia de la rata. La posibilidad de encontraren un modelo animal una cercanía paralela al problema humano de dolores idiopáticos, se expone en el actual trabajo

    Additional file 1: of Sex differences in DNA methylation assessed by 450 K BeadChip in newborns

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    Sex-associated autosomal DMPs. Results for all significant autosomal DMPs associated with sex in CHAMACOS newborns ranked by P value. (CSV 150 kb

    Additional file 3: of Sex differences in DNA methylation assessed by 450 K BeadChip in newborns

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    Summary of sex-associated DMRs. Number of DMRs significantly hyper- and hypo-methylated in newborn girls compared to boys at FDR multiple testing threshold (q < 0.05), for all DMRs, and then stratified by autosomes and X chromosome. (XLSX 9 kb

    Adiponectin and Leptin Trajectories in Mexican-American Children from Birth to 9 Years of Age

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    <div><p>Objectives</p><p>To address molecular mechanisms underlying obesity development, we examined patterns of critical metabolism-related hormones, adiponectin and leptin (adipokines), over childhood.</p><p>Subjects and Design</p><p>Plasma adiponectin and leptin were measured in 80 Mexican-American children at birth and again at 2, 5, and 9 years from the ongoing prospective cohort followed by the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS). We used a mixture modeling approach to identify patterns in adipokine trajectories from birth to 9 years.</p><p>Results</p><p>Leptin was positively related to child body size within all ages, however adiponectin had inverse and weaker associations with BMI at 2, 5, and 9 years. Correlations between adipokine levels over the 0–2, 2–5, and 5–9-year periods increased for both leptin (r = 0.06, 0.31 and 0.62) and adiponectin (r = 0.25, 0.41 and 0.46). Our mixture modeling approach identified three trajectory clusters for both leptin (1L [slowly-rising], 2L [rapidly-rising], and 3L [stable]) and adiponectin (1A [steep-dropping and rebounding], 2A [moderately-dropping], and 3A [stable]). While leptin groups were most separated over the 2–9-year period, adiponectin trajectories displayed greatest heterogeneity from birth to 2 years. Children in the rapidly-rising 2L group had highest BMI and waist circumference at 9 years. Further, children with greater birth weight had increased odds of belonging to this high risk group (OR = 1.21 95% CI 1.03, 1.43, compared to stable group 3L). Children whose mothers consumed more sugar-sweetened beverages during pregnancy were at risk of being in the steep-dropping 1A group (OR = 1.08, 95% CI 1.01, 1.17, compared to stable group 3A).</p><p>Conclusion</p><p>Our results highlight developmental differences in leptin and adiponectin over the childhood period. Leptin closely reflects child body size however factors affecting adiponectin and long-term consequences of its changes over infancy need to be further explored.</p></div

    (A) Individual child adiponectin trajectories.

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    <p>Black rectangles indicate age at which adiponectin was measured. Orange, blue, and green trajectories comprise groups 1A, 2A, and 3A, respectively, as identified by vertically-shifted mixture modeling (VSMM). (B) VSMM-defined adiponectin trajectory groups. (C) Individual child leptin trajectories. Purple, orange, and dark blue trajectories comprise groups 1L, 2L, and 3L. (D) VSMM-defined leptin trajectory groups.</p
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